个人简介

B.Sc., 1976, Nanyang University; Ph. D., 1980, University of Victoria; Post-doctoral Fellow, 1980-2, University of California at Berkeley and Lawrence Berkeley Laboratory

研究领域

Organic Synthesis

Organic Synthesis Our research interests are centred mainly on the studies of conjugated aromatic systems going from theoretically interesting molecules to organic materials for specific applications. A separate effort focuses on the investigation of selected Chinese medicinal plants. The annulene 1 has been used as a probe to study the various annelation and conjugation effects on its diatropicity. Experimentally measurable chemical shifts have been correlated with theoretically calculated bond orders and resonance energies. 3, for example, is a novel model shown to completely nullify the ring current in1 through annelation. Ring current shielding effect of 1 was found to extend to about 14 Ã… above the mean molecular plane in model 4 Collaborative work with materials scientists involves the synthesis of a series of conjugated polymers, which exhibit tuneable photoluminescence, by linking alternatively oxadiazole, carbazole, thiophene and/or benzene derivatives. Silicon-containing PPV and related alternating copolymers have also been shown to be promising green and green-blue emissive materials for light-emitting device application. ollaborative work with surface scientists covers the investigation of chemisorption of aromatic and conjugated molecules on silicon surfaces. Benzene and several heteroaromatic systems, for example, have been found to bind to adjacent adatom and rest atom on the Si(111)-7x7 surface throughs bonds. Extension of this work may lead to modified silicon surfaces with chemically bonded functions and/or unique organic synthesis on active surfaces. A focused collaborative effort with a medical team has been directed to the isolation of bioactive compound(s) from a Chinese medicinal plant proven to exhibit immuno-suppressive properties.

近期论文

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Z. Fang, M. Samoc, R. D. Webster, A. Samoc, Y.-H. Lai, Triphenylamine derivatized phenylacetylene macrocycle with large two-photon absorption cross-section. Tetrahedron Letters (U.K.), 53 (2012): 4885-4888. Z. Fang, V. Chellappan, R. D. Webster, L. Ke, T. Zhang, B. Liu and Y.-H. Lai, Bridged-triarylamine starburst oligomers as hole transporting materials for electroluminescent devices. Journal of Materials Chemistry (U.K.), 22 (2012): 15397-15404. G. Wang, J. Geng, X. Zhang, L. Cai, D. Ding, K. Li, L. Wang, Y.-H. Lai and B. Liu, Pyrene-based water dispersible orange emitter for one- and two-photon fluorescence cellular imaging. Polymer Chemistry (U.K.), 3 (2012): 2464-2470. G. Wang, X. Zhang, J. Geng, K. Li, D. Ding, K.-Y. Pu, L. Cai, Y.-H. Lai and B. Liu, Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging. Chemistry - A European Journal (Germany), 18 (2012): 9705-9713. F. Wang, T. T. Lin, C. He, H. Chi, T. Tang and Y.-H. Lai, Azulene-containing organic chromophores with tunable near-IR absorption in the range of 0.6 to 1.7 μm. Journal of Materials Chemistry (U.K.), 22 (2012): 10448-10451. S. Zhang, T. H. Koh, W. K. Seah, Y.-H. Lai, M. A. Elgar and D. Li, A novel property of spider silk: chemical defence against ants. Proceedings of the Royal Society B (U.K.), 279 (2012): 1824-1830. G. Wang, K.-Y. Pu, X. Zhang, K. Li, L. Wang, L. Cai, D. Ding, Y.-H. Lai and B. Liu, Star-shaped glycosylated conjugated oligomer for two-photon fluorescence imaging of live cells. Chemistry of Materials (U.S.A.), 23 (2011), 4428-4434. X. Gu and Y.-H. Lai, Triptycene: No homoconjugation effect for extending optical properties of π-conjugated oligomers. Organic Letters (U.S.A.), 12 (2010): 5200-5203. T.-G. Peck and Y.-H. Lai, Conformational isomerism in 1,2-di-o-tolylnaphthalenes: selective rotation of the 2-aryl ring. Tetrahedron (U.K.), 69 (2009): 3664-3667. J. Gao and Y.-H. Lai, Narrow bandgap and enhanced electroconductivity in a dihydro-pyrene-thiophene copolymer. Polymer (U.K.), 50 (2009), 1830-1834. Z. Fang, X. Zhang Y.-H. Lai and B. Liu, Bridged triphenylamine based molecules with large two-photon absorption cross sections in organic and aqueous media. Chemical Communications (U.K.), No. 8 (2009): 920-922. Y. Lin and Y.-H. Lai, Effect of higher non-benzenoids in optical properties of dihydropyrene-thiophene and dihydropyrene-phenylenevinylene copolymers. Journal of Polymer Science Part A - Polymer Chemistry (U.S.A.), 47 (2009): 1795-1803. Z. Fang, T.-L. Teo, L. Cai, Y.-H. Lai, A. Samoc and M. Samoc, Bridged triphenylamine-based dendrimers: tuning enhanced two-photon absorption performance with locked molecular planarity. Organic Letters (U.S.A.), 11 (2009): 1-4. H. H. Tang, Y. J. Dai, Y. X. Shao, Y. S. Ning, J. Y. Huang, Y.-H. Lai, B. Peng, W. Huang and G. Q. Xu, The dissociative adsorption of unsaturated alcohols on Si(111)-7x7. Surface Science (U.S.A.), 602 (2008): 2647-2657. S.-Y. Yoon and Y.-H. Lai, 10a-(4-Biphenyl)-10b-methyl-10a,10b-dihydropyrene: conformational study and ring current effect. Tetrahedron Letters (U.K.), 49 (2008): 4282-4285. J. Xu, W.-L. Wang, T. Lin, Z. Sun, Y.-H. Lai, Molecular assembly of dithiaparacyclophanes mediated by non-covalent X...X, X...Y and C-H...X (X, Y=Br, S, N) interactions. Supramolecular Chemistry (U.K.), 20 (2008): 723-730. W. H. Jin, J. Ni, Y.-H. Lai, J. Pei, Photophysical properties and electropolymerization of regioregular head-to-tail oligothiophenes functionalized 9,9-spirobifluorene derivatives. Acta Physico-Chimica Sinica (China), 23 (2007): 459-465. H. H. Tang, Y. H. Cai, Y. S. Ning, Y.-H. Lai and G. Q. Xu, A selective [4+2]-like cycloaddition of α,β-unsaturated ketone on Si(111)-7x7. Surface Science (U.S.A.), 601 (2007): 3293-3302. W. Wang, J. Xu, Z. Sun, X. Zhang, Y. Lu and Y.-H. Lai, Effect of transannular π-π interaction on emission spectral shift and fluorescence quenching in dithia[3.3]paracyclophane-fluorene copolymers. Macromolecules (U.S.A.), 39 (2006): 7277-7285. W. Wang, J. Xu and Y.-H. Lai, Bipyridinophane-containing conjugated polymers modulated with an intramolecular aromatic C-H/π Interaction. Journal of Polymer Science Part A - Polymer Chemistry (U.S.A.), 44 (2006): 4154-4164.