Cowling, Victoria - University of Dundee

个人简介

2015 British Society of Cell Biology Women in Cell Biology Award 2014 EMBO Young Investigator 2013 MRC Senior Fellowship 2011 Lister Institute Prize Fellowship 2007 MRC Career Development Award 2007 Research Group Leader, Life Sciences, University of Dundee 2003-2007 Post-doctoral research with Prof. Michael Cole, Dartmouth College, NH, USA and Princeton University, NJ, USA. “Regulation and Function of c-Myc” 1997-2002 PhD Biochemistry with Prof. Julian Downward and Prof. Gerard Evan. Imperial Cancer Research Fund, London, UK. Thesis “Regulation of Caspase Activation during Programmed Cell Death” 1994-1997 Emmanuel College, Cambridge University, UK. B.A. (Hons) Natural Sciences. Part II Zoology

近期论文

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Lombardi O, Varshney D, Phillips NM and Cowling VH (2016) c-Myc deregulation induces mRNA capping enzyme dependency Oncotarget 2016 DOI: 10.18632/oncotarget.12701 PMID: 27756891 Grasso L, Suska O, Davidson L, Gonatopoulos-Pournatzis T, Williamson R, Wasmus L, Wiedlich S, Peggie M, Stavridis MP, Cowling VH. (2016) mRNA Cap Methylation in Pluripotency and Differentiation. Cell Rep. 2016 Jul 20. pii: S2211-1247(16)30858-0. doi: 10.1016/j.celrep.2016.06.089. [Epub ahead of print] PMID:27452456 Varshney D, Petit AP, Bueren-Calabuig JA, Jansen C, Fletcher DA, Peggie M, Weidlich S, Scullion P, Pisliakov AV, Cowling VH. (2016) Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. Nucleic Acids Res. 2016 Jul 15. pii: gkw637. [Epub ahead of print] PMID:27422871 Aregger M, Kaskar A, Fernandez-Sanchez ME, Simone Weidlich S and Cowling VH (2016) CDK1-cyclinB activates RNMT co-ordinating mRNA cap methylation with G1 phase transcription Mol Cell. 2016 Mar 3;61(5):734-46. doi: 10.1016/j.molcel.2016.02.008. View Paper Preston GC, Sinclair LV, Kaskar A, Hukelmann JL, Navarro MN, Ferrero I, MacDonald HR, Cowling VH and Cantrell DA (2015) Single Cell Tuning of Myc Expression by Antigen Receptor Signal Strength and Interleukin 2 in T Lymphocytes EMBO J. 2015 Jul 1. pii: e20149025 View Paper Cowling VH, Turner S and Cole MD (2014) Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate ribosome biogenesis in oncogenesis Oncogene. 2014 Jul 3;33(27):3519-27. doi: 10.1038/onc.2013.338. Epub 2013 Sep 9. View Paper Gonatopoulos-Pournatzis T and Cowling VH (2014) RAM function is dependent on Kapb2–mediated nuclear entry Biochemical J 2013 2014 Feb 1;457(3):473-84. doi: 10.1042/BJ20131359 View Paper Aregger M and Cowling VH (2013) Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites Biochem J. 2013 Oct 1;455(1):67-73. doi: 10.1042/BJ20130378 View Paper Gonatopoulos-Pournatzis T, Dunn S, Bounds R, and Cowling VH (2011) RAM/Fam103a1 is required for mRNA cap methylation Molecular Cell 2011 Nov18;44(4):585-596 View Paper Cowling VH (2010) Enhanced mRNA cao methylation increases Cyclin D1 expression and promotes cell transformation Oncogene. 2010 Feb 11;29(6):930-6. Epub 2009 Nov 16. View Paper Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, and Cowling VH (2009) S-Adenosyl Homocysteine Hydrolase (SAHH) is required for Myc-induced mRNA cap methylation, protein synthesis and cell proliferation Mol Cell Biol 2009, Dec;29(23):6182-91. Epub 2009 Oct 5. View Paper