个人简介

Education: B.S., B.A., 1982, Washington and Lee University; Ph.D. 1987, California Institute of Technology Awards: Postdoctoral Fellow, ETH Zurich, 1988. NSF Young Investigator, 1992; A.P. Sloan Fellow, 1993; Union Carbide Innovation Award, 1993; Phi Beta Kappa Undergraduate Teaching Award, 1993; Bing Teaching Award, 1994; Arthur C. Cope Scholar Award, 1995; Fresenius Award, 1995; Alan T. Waterman Award, 1996; Walter J. Gores Teaching Award, 1997; Wilhelm Manchot Professorship, 1997; Alexander von Humbold Stiftung Award, 2001; Bass University Fellow in Undergraduate Education, 2005; Cooperative Research Award in Polymer Science and Engineering, 2009; Presidential Green Chemistry Challenge Award (E.P.A.), 2012.

研究领域

Catalysis/Inorganic/Organometallic/Polymer

Our group applies mechanistic principles to develop new concepts in catalysis. A particular focus is the development of organometallic and organic catalysts for the synthesis of complex macromolecular architectures. In organometallic catalysis, we investigate catalysts that can access multiple kinetic states during a polymerization reaction in order to control sequence distribution. We have devised a novel strategy for the synthesis of elastomeric polypropylene utilizing a metallocene catalyst whose structure was designed to interconvert between chiral and achiral coordination geometries on the timescale of the synthesis of a single polymer chain. We have also developed a novel method for the synthesis of alternating copolymers of ethylene and propylene by exploiting catalysts that can access multiple coordination sites that exhibit different kinetic selectivities towards the two monomers. In collaboration with Jim Hedrick of IBM laboratories, we have developed an extensive platform of organic catalysts for the controlled ring-opening polymerization of lactones. Mechanistic studies of nucleophilic N-heterocyclic carbene catalysts revealed an unusual zwitterionic mechanism which enabled the synthesis of high molecular weight cyclic polyesters, a novel topology for these biodegradable and biocompatible macromolecules. These efforts combine elements of mechanistic organic and organometallic chemistry, polymer synthesis, and homogeneous catalysis to rationally design new macromolecular structures.

近期论文

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Brown, H. A.; Chang, Y. A.; Waymouth, R. M. "Zwitterionic Polymerization to Generate High Molecular Weight Cyclic Poly(carbosiloxanes), J. Am. Chem. Soc., 2013, 135, 18738-18741. doi: 10.1021/ja409843v Brownell, K. R.; McCrory, C. C. M.; Chidsey, C. E. D.; Perry, R. H.; Zare, R. N.; Waymouth. R. M. “Electrooxidation of Alcohols Catalyzed by Amino Alcohol Ligated Ruthenium Complexes, J. Am. Chem. Soc., 2013, 135, 14299-14305. doi: 10.1021/ja4055564 Chung, Y.-L.; Olsson, J. V.; Li, R.J.; Frank, C. W.; Waymouth, R. M.; Billington, S.; Sattely, E. "Graft polymerization of Lactide onto Lignin and Application in Biobased Composites" ACS Sustainable Chem. Eng., 2013, 1, 1231-1238. doi: 10.1021/sc4000835 Brown, H. A.; Waymouth, R. M. "Zwitterionic Ring-Opening Polymerization for the Synthesis of High Molecular Weight Cyclic Polymers" Acc. Chem. Res. 2013, 46, 2585-2596. doi: 10.1021/ar400072z Chung, K.; Banik, S. M.; De Crisci, A. G.; Pearson, D. M.; Blake, T.; Olsson, J. V.; Ingram, A. J.; Zare, R. N.; Waymouth, R. M. "Chemoselective Pd-catalyzed Oxidation of Polyols: Synthetic Scope and Mechanistic Studies" J. Am. Chem. Soc., 2013, 135, 7593-7602. doi: 10.1021/ja4008694 De Crisci, A., Chung, K., Oliver, A., Waymouth, R. M. "Chemo- and Stereoselective Alcohol Oxidation with Chiral Palladium Catalysts" Organometallics, 2013, 32, 2257-2266. doi: 10.1021/om4001549 Kiesewetter, E. T.; Waymouth, R. M. "Octahedral Group IV Bis(phenolate) Catalysts for 1-Hexene Homopolymerization and Ethylene/1-Hexene Copolymerization", Macromolecules, 2013, 46, 2569-2575. doi: 10.1021/ma400116w Coady, D. J.; Sardon, H.; Engler, A. C.; Jones, G. O.; Horn, H. W.; Waymouth, R. M.; Rice, J. E.; Yang, Y. Y.; Hedrick, J. L. "Polymerizing Base Sensitive Cyclic Carbonates Using Acid Catalysts" ACS Macro Lett. 2013, 2, 306-312. Simon, J.; Olsson, J. V.; Kim, H.; Tenney, I. F.; Waymouth, R. M. "Semicrystalline Dihydroxyacetone Copolymers Derived from Glycerol " Macromolecules, 2012, 45, 9275-9281. doi: 10.1021/ma302311h Brown, H.; De Crisci, A.; Hedrick, J. L.; Waymouth, R. M. "Amidine-Mediated Zwitterionic Polymerization of Lactide" ACS Macro Letters, 2012, 1, 1113-1115. doi: 10.1021/mz300276u Edward, J.A.; Kim, H.; Kiesewetter, M. K.; Hedrick, J. L.; Waymouth, R. M. "Organocatalytic Synthesis of Quinine-functionalized Carbonate Polymers" Biomacromolecules, 2012, 13(8), 2483-2489. doi: 10.1021/bm300718b Geihe, E. I.; Cooley, C. B.; Simon, J.; Kiesewetter, M. K.; Edward, J. A.; Hickerson, R. P.; Kaspar, R. L; Hedrick, J. L.; Waymouth, R. M.; Wender, P. A., "Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells" Proc. Nat. Acad. Sci. 2012, 109(33), 13171-13176, doi: 10.1073/pnas.1211361109 Kim, H.; Hedrick, J. L.; Waymouth, R. M. "Facile Synthesis of Functionalized Lactones and Organocatalytic Ring Opening Polymerization" ACS Macro Letters, 2012, 1, 845-847. doi: 10.1021/mz3001397 Randoll, S.; Kiesewetter, E. T.; Waymouth, R. M. " Stereo- and Regioselective Propylene Polymerization with Group 4 bis(phenolate) Ether Complexes", J. Polym. Sci. A., Polym. Chem., 2012, 50, 2604-2611. Perry, R. H.; Chingin, K.; Brownell, K. R.; Waymouth, R. M.; Cahill, T. J.; Zare, R. N. "Transient Ru-Methyl Formate Intermediates Generated in Noyori Transfer Hydrogenation Catalysis" Proc. Nat. Acad. Sci. 2012, 109(7), 2246-2250. doi: 10.1073/pnas.1118934109 Shin, E. J.; Jones, A. E.; Waymouth, R. M. "Stereocomplexation in Cyclic and Linear Polylactide Blends" Macromolecules, 2012, 45, 595-598. Kiesewetter, M. K.; Edward, J. A., Kim, H.; Waymouth, R. M. "Polycondensation of Butene-diol: Synthesis of Telechelic 2-Butene-1,4-diol Oligomers" J. Am. Chem. Soc., 2011, 133, 16390-16393. Fukushima, K.; Coulembier, O.; Lecuyer, J. M.; Al-Megren, H. A.; Mohammad, A.; Alsewailem, F. D.; McNeil, M. A.; Dubois, P.; Waymouth, R. M.; Horn, H. W.; Rice, J. E.; Hedrick, J. L. "Closing the Loop on Recycling: Organocatalytic Depolymerization of Poly(ethyleneterephthalate)" J. Polym. Sci. Part A: Polym. Chem., 2011 49, 1273-1281. Pearson, D. M.; Conley, N. R., Waymouth, R. M. “Oxidatively Resistant Ligands for Pd-catalyzed Aerobic Alcohol Oxidation” Organometallics, 2011, 30, 1445-1453. Shin, E. J.; Jeong, W.; Brown, H. A. Koo, B. J., Hedrick, J. L.; Waymouth, R. M. “Synthesis and Crystallization of High Molecular Weight Cyclic Poly(caprolactone)” Macromolecules, 2011, 44, 2773-2779.