Wilson, Duncan - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Sir Henry Dale fellow. University of Aberdeen (2014-present) Postdoctoral researcher. Hans Knoell Institute, Jena, Germany (2007-2014). Doctor of Philosophy. University of Manchester (2003-2006). The role of phosphodiesterases in Candida albicans physiology Bachelor of Science with Honours in Microbiology. University of Glasgow (1999-2003).

研究领域

I am interested in how pathogenic fungi compete with their hosts for essential micronutrients. Certain trace minerals, such as iron and zinc, are actively withheld from pathogens in a process called nutritional immunity. Therefore, pathogenic microbes must have evolved specialised uptake systems in order to proliferate in their hosts and cause disease. I am using a combination of molecular and cellular biology, together with models of host-pathogen interactions, to dissect the mechanisms of micronutrient assimilation by the major human fungal pathogen, Candida albicans. I am particularly interested in the molecular mechanisms of zinc scavenging by this fungus during interactions with host cells.

近期论文

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Malavia, D., Crawford, A. & Wilson, D. 'Nutritional Immunity and Fungal Pathogenesis: The Struggle for Micronutrients at the Host-Pathogen Interface'. Advances in Microbial Physiology. DOI: [ONLINE] DOI: 10.1016/BS.AMPBS.2017.01.006 Wilson, DJ., Naglik, JR. & Hube, B. (2016). 'The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage'. PLoS Pathogens, vol 12, no. 10, e1005867. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PPAT.1005867 [ONLINE] AURA: JOURNAL.PPAT.1005867.PDF Ballou, ER. & Wilson, D. (2016). 'The roles of zinc and copper sensing in fungal pathogenesis'. Current Opinion in Microbiology, vol 32, pp. 128-134. DOI: [ONLINE] DOI: 10.1016/J.MIB.2016.05.013 [ONLINE] AURA: 1_S2.0_S1369527416300686_MAIN.PDF Moyes, DL., Wilson, D., Richardson, JP., Mogavero, S., Tang, SX., Wernecke, J., Hofs, S., Gratacap, RL., Robbins, J., Runglall, M., Murciano, C., Blagojevic, M., Thavaraj, S., Forster, TM., Hebecker, B., Kasper, L., Vizcay, G., Iancu, SI., Kichik, N., Hader, A., Kurzai, O., Luo, T., Kruger, T., Kniemeyer, O., Cota, E., Bader, O., Wheeler, RT., Gutsmann, T., Hube, B. & Naglik, JR. (2016). 'Candidalysin is a fungal peptide toxin critical for mucosal infection'. Nature, vol 532, no. 7597, pp. 64-68. DOI: [ONLINE] DOI: 10.1038/NATURE17625 Kasper, L., Miramon, P., Jablonowski, N., Wisgott, S., Wilson, D., Brunke, S. & Hube, B. (2015). 'Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase and morphology'. Journal of Medical Microbiology, vol 64, no. 7, pp. 714-723. DOI: [ONLINE] DOI: 10.1099/JMM.0.000082 Wilson, D. (2015). 'An evolutionary perspective on zinc uptake by human fungal pathogens'. Metallomics, vol 7, no. 6, pp. 979-985. DOI: [ONLINE] DOI: 10.1039/C4MT00331D [ONLINE] AURA: C4MT00331D.PDF Wilson, D., Mayer, FL., Miramón, P., Citiulo, F., Slesiona, S., Jacobsen, ID. & Hube, B. (2014). 'Distinct roles of Candida albicans-specific genes in host-pathogen interactions'. Eukaryotic Cell, vol 13, no. 8, pp. 977-989. DOI: [ONLINE] DOI: 10.1128/EC.00051-14 [ONLINE] AURA: WILSON_AUG_PAPER_EC_3_MAR_2014_REVISION_FIGS.PDF Tyc, KM., Kühn, C., Wilson, D. & Klipp, E. (2014). 'Assessing the advantage of morphological changes in Candida albicans: a game theoretical study'. Frontiers in Microbiology, vol 5, 41. DOI: [ONLINE] DOI: 10.3389/FMICB.2014.00041 [ONLINE] AURA: FMICB_05_00041.PDF Mech, F., Wilson, D., Lehnert, T., Hube, B. & Thilo Figge, M. (2014). 'Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach'. Cytometry Part A : Journal of the International Society for Analytical Cytology, vol 85, no. 2, pp. 126-139. DOI: [ONLINE] DOI: 10.1002/CYTO.A.22418 Wilson, D., Hebecker, B., Moyes, DL., Miramón, P., Jablonowski, N., Wisgott, S., Allert, S., Naglik, JR. & Hube, B. (2013). 'Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection'. Antimicrobial Agents and Chemotherapy, vol 57, no. 10, pp. 5178-5180. DOI: [ONLINE] DOI: 10.1128/AAC.01244-13