Wallace, Heather - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Heather Wallace (neé Moyes) graduated in Biochemistry from the University of Glasgow and moved to Aberdeen to undertake a PhD, sponsored by the MRC, in the Department of Biochemistry under the supervision of Professor Hamish Keir. She studied the biochemistry of the polyamines in normal and virus infected cells and graduated PhD. Heather continued her studies in polyamine metabolism through both MRC and CRC postdoctoral fellowships in the Department of Biochemistry before being appointed the Wellcome Lecturer in Clinical Pharmacology in the Department of Therapeutics and Clinical Pharmacology. Later that year she was appointed a "New Blood" lecturer in Molecular Pharmacology (now Biomedical Sciences). She was awarded a University Research Fellowship and was then appointed Senior Lecturer and Professor. Professor Wallace is currently a Deputy Chairman of the Biochemical Journal having been an editor for 7 years. She is an active member of several professional Societies including the Biochemical Society, British Pharmacological Society, British Toxicological Society and British Association for Cancer Research. She has organised a number of International Meetings, has been a member of the Scientific Advisory Board on several International Conferences and is a previous Chair of a Gordon Research Conference. Heather is enthusiastically involved in connecting academia with the pharmaceutical and biotechnology industry and works to facilitate scientific excellence and innovation in the discovery of new medicines. Prof Wallace is immediate Past President of the BTS and is a member of the PPE committee of the British Pharmacological Society. She sits on the Committee for Carcinogenicity (COC), Herbal Medicine Advisory Committee (HMAC), Paediatric Medicnes Expert Advisry Group (MHRA), Specialty Advisory Committee (Toxicology) and is the UK CPD Advisor for Toxicology for the Royal College of Pathologists. She is also an evaluator and an assessor for the European Commission. Heather was elected a Fellow of the following Societies: the Royal College of Pathologists ; the British Toxicology Society; the British Pharmacological Society; the Royal Society of Chemistry; the Society of Biology. She is also a European Registered Toxicologist and a member of the UK Register of Toxicologists.

研究领域

Professsor Wallace's research interests are the role of polyamines in cell growth and apoptosis (cell death) particularly in relation to the possible regulatory role played by the polyamines in malignancy. The polyamine pathway is a potential target for the development of anticancer strategies including chemotherapeutic, chemoprevention and drug delivery systems. Recent interests include the understanding the mechanism of chemoprevention of human cancers by drugs such as the non steroidal anti-inflammatory drugs (NSAIDs) and natural products, the development of polyamine analogues as novel chemotherapeutic agents and using the polyamine transport system for selective delivery of drugs. Further details can be found on the Polyamine Research Group web pages.

近期论文

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EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen, HK., Jan, A., Barreg?rd, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Hogstrand, C., Hoogenboom, LR., Nebbia, C., Oswald, I., Petersen, A., Rose, M., Roudot, A-C, Schwerdtle, T., Vollmer, G., Wallace, H., Grasl-Kraupp, B., Grob, K., Penninks, A., Binaglia, M., Torres, RR. & Vleminckx, C. (2017). 'Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils'. EFSA Journal. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2017.4656 [ONLINE] AURA: KNUTSEN_ET_AL_2017_EFSA_JOURNAL.PDF EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen, HK., Barreg?rd, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, LR., Nebbia, CS., Oswald, I., Petersen, A., Rose, M., Roudot, A-C, Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., Dall'Asta, C., Gutleb, A., Metzler, M., Parent-Massin, D., Binaglia, M., Steinkellner, H. & Alexander, J. (2017). 'Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms'. EFSA Journal. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2017.4655 [ONLINE] AURA: KNUTSEN_ET_AL_2017_EFSA_JOURNAL_1_.PDF EFSA Panel on Contaminants in the Food Chain (2016). 'Erucic acid in feed and food'. EFSA Journal, vol 14, no. 11, 4593, pp. 1-173. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4593 [ONLINE] AURA: KNUTSEN_ET_AL_2016_EFSA_JOURNAL.PDF Wilks, MF., Blaauboer, BJ., Schulte-Hermann, R., Wallace, HM., Galli, CL., Gr?nlund, MH., Matovic, V., Teixeira, JP., Johanna Zilliacus, J., Basaran, N., Bonefeld-J?rgensen, EC., Bourrinet, P., Brueller, W., Claude, N., Miranda, JP., Gundert-Remy, U., H?kansson, H., Kovatsi, L., Liesivuori, J., Lindeman, B., Lison, D., Leconte, I., Lopez, EM., Murias, M., Michel, C., Scheepers, PTJ., Stanley, L. & Tsatsakis, A. (2016). 'The European Registered Toxicologist (ERT): Current status and prospects for advancement'. Toxicology Letters, vol 259, pp. 151-155. DOI: [ONLINE] DOI: 10.1016/J.TOXLET.2016.06.014 EFSA Panel on Contaminants in the Food Chain (CONTAM) (2016). 'Malachite green in food'. EFSA Journal, vol 14, no. 7, e04530, pp. 1-80. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4530 [ONLINE] AURA: _CONTAM_2016_EFSA_JOURNAL_1_.PDF Panel on Contaminants in the Food Chain (2016). 'Presence of microplastics and nanoplastics in food, with particular focus on seafood'. EFSA Journal, vol 14, no. 6, 4501, pp. 1-30. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4501 [ONLINE] AURA: EFSA4501.PDF Panel on Contaminants in the Food Chain (2016). 'Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food'. EFSA Journal, vol 14, no. 5, 4426, pp. 1-159. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4426 [ONLINE] AURA: EFSA4426.PDF Li, J., Cameron, GA. & Wallace, HM. (2016). 'Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells'. Amino Acids, vol 48, no. 4, pp. 1003-1012. DOI: [ONLINE] DOI: 10.1007/S00726-015-2143-6 [ONLINE] AURA: ART_3A10.1007_2FS00726_015_2143_6.PDF Panel on Contaminants in the Food Chain & Dinovi, M. (2016). 'Acute health risks related to the presence of cyanogenic glycosides in raw apricot kernels and products derived from raw apricot kernels'. EFSA Journal, vol 14, no. 4, 4424. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4424 [ONLINE] AURA: EFS24424.PDF EFSA Panel on Contaminants in the Food Chain (2016). 'Appropriateness to set a group health-based guidance value for zearalenone and its modified forms'. EFSA Journal, vol 14, no. 4, 4425, pp. 1-46. DOI: [ONLINE] DOI: 10.2903/J.EFSA.2016.4425 [ONLINE] AURA: EFSA4425.PDF