Spanò, Stefania - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Education 1995 Laurea (MSc; summa cum laude) in Biological Sciences, University of Bologna, Italy. Supervisor: Prof. Giuseppe Gargiulo 2002 PhD in Life Sciences, Open University, London, UK. Supervisor: Dr. Daniela Corda Research Positions 2002-2004 Postdoctoral fellow in the Department of Cell Biology and Oncology, "Consorzio Mario Negri Sud" Research Institute, Italy. 2004-2009 Postdoctoral Associate with Dr. Jorge Galán, Dep. of Microbial Pathogenesis, Yale University School of Medicine, USA. 2009-2013 Associate Research Scientist, Dep. of Microbial Pathogenesis, Yale University School of Medicine, USA.

研究领域

Salmonella Typhi is an exclusive human pathogen and the cause of typhoid fever, a life-threatening systemic disease that affects millions of people and kills more than 200,000 every year. The goal of my research is to understand the molecular and cellular mechanisms of Salmonella Typhi pathogenesis and its human-adaptation. We are using an advanced cell biological approach, where imaging and biochemical analyses are integrated by genetic, genomic and proteomic methods. These studies also intend to address fundamental questions in the cell biology of the host. A central question of our research is about the host mechanisms preventing S. Typhi from infecting non-susceptible hosts.

近期论文

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Solano-Collado, V., Rofe, A. & Spano, S. 'Rab32 restriction of intracellular bacterial pathogens'. Small GTPases, pp. 1-8. DOI: [ONLINE] DOI: 10.1080/21541248.2016.1219207 [ONLINE] AURA: RAB32_RESTRICTION_OF_INTRACELLULAR_BACTERIAL_PATHOGENS.PDF Spano, S., Gao, X., Hanneman, S., Lara-Tejero, M. & Galan, JE. (2016). 'A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP'. Cell Host & Microbe, vol 19, no. 2, pp. 216-226. DOI: [ONLINE] DOI: 10.1016/J.CHOM.2016.01.004 Onnis, A., Finetti, F., Patrussi, L., Gottardo, M., Cassioli, C., Spano, S. & Baldari, CT. (2015). 'The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis'. Cell Death and Differentiation, vol 22, no. 10, pp. 1687-1699. DOI: [ONLINE] DOI: 10.1038/CDD.2015.17 [ONLINE] AURA: ONNIS_ET_AL._2C_2015.PDF Spano, S. (2014). 'Host restriction in Salmonella: insights from Rab GTPases'. Cellular Microbiology, vol 16, no. 9, pp. 1321-1328. DOI: [ONLINE] DOI: 10.1111/CMI.12327 Kohler, AC., Spano, S., Galan, JE. & Stebbins, CE. (2014). 'Structural and enzymatic characterization of a host-specificity determinant from Salmonella'. Acta crystallographica. Section D, Biological crystallography, vol 70, no. 2, pp. 384-391. DOI: [ONLINE] DOI: 10.1107/S1399004713028393 Spano, S. & Galán, JE. (2013). 'A novel anti-microbial function for a familiar Rab GTPase'. Small GTPases, vol 4, no. 4. DOI: [ONLINE] DOI: 10.4161/SGTP.27282 [ONLINE] AURA: 2013SGTP0061R_CHANGES.DOCX Spanò, S. & Galán, JE. (2012). 'A Rab32-dependent pathway contributes to Salmonella typhi host restriction'. Science, vol 338, no. 6109, pp. 960-963. DOI: [ONLINE] DOI: 10.1126/SCIENCE.1229224 Valente, C., Turacchio, G., Mariggiò, S., Pagliuso, A., Gaibisso, R., Di Tullio, G., Santoro, M., Formiggini, F., Spanò, S., Piccini, D., Polishchuk, RS., Colanzi, A., Luini, A. & Corda, D. (2012). 'A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation'. Nature Cell Biology, vol 14, no. 4, pp. 343-354. DOI: [ONLINE] DOI: 10.1038/NCB2445 Spanò, S., Liu, X. & Galán, JE. (2011). 'Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella'. PNAS, vol 108, no. 45, pp. 18418-18423. DOI: [ONLINE] DOI: 10.1073/PNAS.1111959108 Spanò, S. & Galán, JE. (2008). 'A novel pathway for exotoxin delivery by an intracellular pathogen'. Current Opinion in Microbiology, vol 11, no. 1, pp. 15-20. DOI: [ONLINE] DOI: 10.1016/J.MIB.2007.12.002