Shewan, Derryck - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Derryck Shewan graduated in Physiology from the University of Aberdeen in 1991, having gained a particular interest in the mechanisms of axon guidance. He undertook a studentship with Prof Jim Cohen at Guy’s Hospital Medical School, under the co-supervision of Prof Martin Berry, in the Developmental Neurobiology department, which has since evolved to the MRC Unit for Developmental Neurobiology at Hunt’s House, Kings College London. He gained his PhD in Anatomy and Cell Biology in 1994 having studied mechanisms of axon growth and regeneration, building up an appreciation of the changing nature of neuronal behaviour during development. In 1994 Dr Shewan was appointed a Research Fellow in Dr Cohen’s laboratory, which involved some time working with Dr Geneviève Rougon and her colleagues at the CNRS Faculté des Sciences de Luminy in Marseille. In 1997 he moved to the Department of Anatomy at the University of Cambridge as a Research Associate in Prof Christine Holt’s laboratory. Having spent 3 years studying the development of the visual system, Dr Shewan moved on in 2000 to the Department of Physiology at the University of Cambridge as a Research Associate in Professor James Fawcett’s laboratory. In 2001 he moved with Professor Fawcett’s group to he Cambridge Centre for Brain Repair. Dr Shewan was appointed Lecturer in Biomedical Sciences at the University of Aberdeen in 2003, and promoted to Senior Lecturer in 2006. He now forms part of the Aberdeen University Spinal Injury Research Group. He was afforded the College of Life Sciences and Medicine Award for Excellence in Teaching in 2009, nominated again in 2010, nominated for the Students Association award for Supporting Students in 2011 and afforded the Students Association award for most Accessible Lecturer (Champion for Disabilities) in 2016.

研究领域

Dr Shewan is interested in the changing intracellular signalling mechanisms that accompany neuronal maturation. In particular, he focuses on the growth and regenerative capacities of embryonic and adult neurons in order to find differences that may help to explain why neurons of the central nervous system become incapable of regenerating after injury. A more detailed synopsis of Dr Shewan's work can be found at the Cell and Developmental Biology Research Theme at the University of Aberdeen.

近期论文

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McKean, JS., Murray, F., Gibson, G., Shewan, DA., Tucker, SJ. & Nixon, GF. (2015). 'The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP'. Cardiovascular Research, vol 107, no. 4, pp. 546-555. DOI: [ONLINE] DOI: 10.1093/CVR/CVV176 [ONLINE] AURA: 546.FULL.PDF Erskine, L., Reijntjes, S., Pratt, T., Denti, L., Schwarz, Q., Vieira, J., Alakakone, B., Shewan, D. & Ruhrberg, C. (2011). 'VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm'. Neuron, vol 70, no. 5, pp. 951-965. DOI: [ONLINE] DOI: 10.1016/J.NEURON.2011.02.052 Murray, AJ., Tucker, SJ. & Shewan, DA. (2009). 'cAMP-Dependent Axon Guidance is Distinctly Regulated by Epac and Protein Kinase A'. Journal of Neuroscience, vol 29, no. 49, pp. 15434-15444. DOI: [ONLINE] DOI: 10.1523/JNEUROSCI.3071-09.2009 Murray, AJ., Peace, AG. & Shewan, DA. (2009). 'cGMP promotes neurite outgrowth and growth cone turning and improves axon regeneration on spinal cord tissue in combination with cAMP'. Brain Research, vol 1294, pp. 12-21. DOI: [ONLINE] DOI: 10.1016/J.BRAINRES.2009.07.071 Murray, AJ. & Shewan, DA. (2008). 'Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration'. Molecular and Cellular Neuroscience, vol 38, no. 4, pp. 578-588. DOI: [ONLINE] DOI: 10.1016/J.MCN.2008.05.006 Adcock, KH., Brown, DJ., Shearer, MC., Shewan, D., Schachner, M., Smith, GM., Geller, HM. & Fawcett, JW. (2004). 'Axon behaviour at Schwann cell-astrocyte boundaries: manipulation of axon signalling pathways and the neural adhesion molecule L1 can enable axons to cross'. European Journal of Neuroscience, vol 20, no. 6, pp. 1425-1435. DOI: [ONLINE] DOI: 10.1111/J.1460-9568.2004.03573.X Shewan, D., Dwivedy, A., Anderson, R. & Holt, C. (2002). 'Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway'. Nature Neuroscience, vol 5, pp. 955-962. DOI: [ONLINE] DOI: 10.1038/NN919