MacCallum, Donna - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

BSc (Hons) Genetics, 1994 PhD in Microbiology, 1998 PGCE in Higher Education Teaching, 2004 Fellow of the Higher Education Academy, 2007 Fellow of the Society of Biology, 2013

研究领域

My research has centred on investigating fungal pathogenesis and virulence, focussing mainly on the opportunistic fungal pathogen Candida albicans.

近期论文

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Wagener, J., MacCallum, DM., Brown, GD., Gow, NAR. & Doering, TL. (ed.) (2017). 'Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions'. mBio, vol 8, no. 1, e01820-16. DOI: [ONLINE] DOI: 10.1128/MBIO.01820-16 [ONLINE] AURA: CANDIDA_ALBICANS_CHITIN_INCREASES_ARGINASE_1_ACTIVITY_IN_HUM... Day, AM., Smith, DA., Ikeh, MAC., Haider, M., Herrero De Dios, CM., Brown, AJP., Morgan, BA., Erwig, LP., MacCallum, DM. & Quinn, J. (2017). 'Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation'. PLoS Pathogens, vol 13, no. 1, e1006131, pp. 1-27. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PPAT.1006131 [ONLINE] AURA: BLOCKING_TWO_COMPONENT_SIGNALLING_ENHANCES_CANDIDA_ALBICANS_... Ballou, E., Mol Avelar, G., Childers, DS., Mackie, J., Bain, JM., Wagener, J., Kastora, SL., Panea, MD., Hardison, SE., Walker, L., Erwig, LP., Munro, CA., Gow, NAR., Brown, GD., MacCallum, DM. & Brown, AJP. (2016). 'Lactate signalling regulates fungal β-glucan masking and immune evasion'. Nature Microbiology, vol 2, 16238. DOI: [ONLINE] DOI: 10.1038/NMICROBIOL.2016.238 [LINK] HTTPS://EORDER.SHERIDAN.COM/3_0/APP/ORDERS/6371/ARTICLE.PHP Liu, Z., Moran, GP., Sullivan, DJ., MacCallum, DM. & Myers, LC. (2016). 'Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp'. PLoS Genetics, vol 12, no. 10, e1006373. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PGEN.1006373 [ONLINE] AURA: TLO_MACCALLUM_MORAN_2016.PDF Ikeh, MAC., Kastora, SL., Day, AM., Herrero-de-Dios, CM., Tarrant, E., Waldron, KJ., Banks, AP., Bain, JM., Lydall, D., Veal, EA., MacCallum, DM., Erwig, LP., Brown, AJP. & Quinn, J. (2016). 'Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis'. Molecular Biology of the Cell, vol 27, no. 17, pp. 2784-2801. DOI: [ONLINE] DOI: 10.1091/MBC.E16-05-0266 [ONLINE] AURA: MOL._BIOL._CELL_2016_IKEH_2784_801.PDF MacKie, J., Szabo, EK., Urgast, DS., Ballou, ER., Childers, DS., MacCallum, DM., Feldmann, J. & Brown, AJP. (2016). 'Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections'. PLoS ONE, vol 11, no. 6, 0158683. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0158683 [ONLINE] AURA: 2016_JOANNA_COPPER_POISONING.PDF Childers, DS., Raziunaite, I., Mol Avelar, G., Mackie, J., Budge, S., Stead, D., Gow, NAR., Lenardon, MD., Ballou, ER., MacCallum, DM. & Brown, AJP. (2016). 'The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence'. PLoS Pathogens, vol 12, no. 4, 1005566, pp. 1-26. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PPAT.1005566 [ONLINE] AURA: JOURNAL.PPAT.1005566.PDF Tillmann, AT., Strijbis, K., Cameron, G., Radmaneshfar, E., Thiel, M., Munro, CA., MacCallum, DM., Distel, B., Gow, NAR. & Brown, AJP. (2015). 'Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans'. PloS one, vol 10, no. 6, e0126940. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0126940 [ONLINE] AURA: PLOSONE_0126940.PDF Vautier, S., Drummond, RA., Chen, K., Murray, GI., Kadosh, D., Brown, AJP., Gow, NAR., MacCallum, DM., Kolls, JK. & Brown, GD. (2015). 'Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity'. Cellular Microbiology, vol 17, no. 4, pp. 445-450. DOI: [ONLINE] DOI: 10.1111/CMI.12388 [ONLINE] AURA: VAUTIER_ET_AL_2014_CELLULAR_MICROBIOLOGY.PDF Wagener, J., Malireddi, RKS., Lenardon, MD., K?berle, M., Vautier, S., Maccallum, DM., Biedermann, T., Schaller, M., Netea, MG., Kanneganti, T-D, Brown, GD., Brown, AJP. & Gow, NAR. (2014). 'Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation'. PLoS Pathogens, vol 10, no. 4, e1004050. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PPAT.1004050 [ONLINE] AURA: FUNGAL_CHITIN.PDF