Lionikas, Arimantas - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

I graduated from the Lithuanian Sports University as a PE teacher in 1992, got a Masters degree in 1994 and was awarded a PhD from the same institution for the work on acute muscle adaptation to exercise using electrical stimulation in 1999. From 1999 to 2000, I was a Guest Researcher at the Department of Physiology and Pharmacology, Karolinska Institute (Advisor prof. Jan Henriksson) in Sweden working on the exercise effects on muscle signaling. From 2001 to 2003, I did a post doctoral work in muscle biology at the Pennsylvania State University (USA) and Uppsala University (Sweden; Advisor prof. Lars Larsson). From 2003 to 2007 I completed my second post doctoral position in quantitative genetics (Advisors Dr. David A. Blizard and Dr. George P. Vogler) at the Pennsylvania State University and worked there as a Research Associate until 2009. In March 2009, I took a post at the School of Medical Science, University of Aberdeen.

研究领域

My research interests focus on the genetic mechanisms underlying variation in skeletal muscle mass and properties of muscle fibres that can affect muscle function. Muscle mass differs more than 2-fold between individuals even when sex and age are taken into account. The number of muscle fibres in homologous muscles can also differ by over 2-fold. Furthermore, skeletal muscle is not a homogeneous tissue but it is composed of a mixture of fast- and slow-twitch fibre types. The proportion of different types in homologous muscles also differs extensively between individuals. For instance, slow-twitch fibres in vastus lateralis can comprise from ~20% to ~80% of all fibres.

近期论文

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Carroll, AM., Cheng, R., Collie-Duguid, ESR., Meharg, C., Scholz, ME., Fiering, S., Fields, JL., Palmer, AA. & Lionikas, A. (2017). 'Fine mapping of genes determining extrafusal fiber properties in murine soleus muscle'. Physiological Genomics, vol 49, no. 3, pp. 141-150. DOI: [ONLINE] DOI: 10.1152/PHYSIOLGENOMICS.00092.2016 Kvedaras, M., Minderis, P., Fokin, A., Ratkevicius, A., Venckunas, T. & Lionikas, A. (2017). 'Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10'. Frontiers in Physiology, vol 8, 9. DOI: [ONLINE] DOI: 10.3389/FPHYS.2017.00009 [ONLINE] AURA: FPHYS_08_00009.PDF Kilikevicius, A., Bunger, L. & Lionikas, A. (2016). 'Baseline Muscle Mass Is a Poor Predictor of Functional Overload-Induced Gain in the Mouse Model'. Frontiers in Physiology. DOI: [ONLINE] DOI: 10.3389/FPHYS.2016.00534 [ONLINE] AURA: FPHYS_07_00534.PDF Minderis, P., Kilikevicius, A., Baltusnikas, J., Alhindi, Y., Venckunas, T., Bunger, L., Lionikas, A. & Ratkevicius, A. (2016). 'Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice'. Scandinavian Journal of Medicine & Science in Sports, vol 26, no. 8, pp. 894-901. DOI: [ONLINE] DOI: 10.1111/SMS.12532 Nicod, J., Davies, RW., Cai, N., Hassett, C., Goodstadt, L., Cosgrove, C., Yee, BK., Lionikaite, V., McIntyre, RE., Remme, CA., Lodder, E., Gregory, JS., Hough, T., Joynson, R., Phelps, H., Nell, B., Rowe, C., Wood, J., Walling, A., Bopp, N., Bhomra, A., Hernandez-Pliego, P., Callebert, J., Aspden, RM., Talbot, NP., Robbins, PA., Harrison, M., Fray, M., Launay, J-M, Pinto, YM., Blizard, DA., Bezzina, CR., Adams, DJ., Franken, P., Weaver, T., Wells, S., Brown, SDM., Potter, PK., Klenerman, P., Lionikas, A., Mott, R. & Flint, J. (2016). 'Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing'. Nature Genetics, vol 48, no. 8, pp. 912-918. DOI: [ONLINE] DOI: 10.1038/NG.3595 [ONLINE] AURA: MANUSCRIPT080416.DOCX Parker, CC., Gopalakrishnan, S., Carbonetto, P., Gonzales, NM., Leung, E., Park, YJ., Aryee, E., Davis, J., Blizard, DA., Ackert-Bicknell, CL., Lionikas, A., Pritchard, JK. & Palmer, AA. (2016). 'Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice'. Nature Genetics, vol 48, no. 8, pp. 919-926. DOI: [ONLINE] DOI: 10.1038/NG.3609 Joyce, PI., Fratta, P., Landman, AS., Mcgoldrick, P., Wackerhage, H., Groves, M., Busam, BS., Galino, J., Corrochano, S., Beskina, OA., Esapa, C., Ryder, E., Carter, S., Stewart, M., Codner, G., Hilton, H., Teboul, L., Tucker, J., Lionikas, A., Estabel, J., Ramirez-Solis, R., White, JK., Brandner, S., Plagnol, V., Bennet, DLH., Abramov, AY., Greensmith, L., Fisher, EMC. & Acevedo-Arozena, A. (2016). 'Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration'. Human Molecular Genetics, vol 25, no. 2, pp. 291-307. DOI: [ONLINE] DOI: 10.1093/HMG/DDV471 [ONLINE] AURA: HUM._MOL._GENET._2016_JOYCE_291_307.PDF Baltusnikas, J., Kilikevicius, A., Venckunas, T., Fokin, A., Bunger, L., Lionikas, A. & Ratkevicius, A. (2015). 'Myostatin dysfunction impairs force generation in extensor digitorum longus muscle and increases exercise-induced protein efflux from extensor digitorum longus and soleus muscles'. Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, vol 40, no. 8, pp. 817-821. DOI: [ONLINE] DOI: 10.1139/APNM-2014-0513 [ONLINE] AURA: BALTUSNIKAS_APNM513_MANUSCRIPT.PDF Baltusnikas, J., Kilikevicius, A., Venckunas, T., Fokin, A., Lionikas, A. & Ratkevicius, A. (2015). 'Regenerated soleus muscle shows reduced creatine kinase efflux after contractile activity in vitro'. Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, vol 40, no. 2, pp. 129-133. DOI: [ONLINE] DOI: 10.1139/APNM-2014-0274 [ONLINE] AURA: BALTUSNIKAS_APNM_0274.R1.PDF Corrochano, S., M?nnikk?, R., Joyce, PI., McGoldrick, P., Wettstein, J., Lassi, G., Raja Rayan, DL., Blanco, G., Quinn, C., Liavas, A., Lionikas, A., Amior, N., Dick, J., Healy, EG., Stewart, M., Carter, S., Hutchinson, M., Bentley, L., Fratta, P., Cortese, A., Cox, R., Brown, SDM., Tucci, V., Wackerhage, H., Amato, AA., Greensmith, L., Koltzenburg, M., Hanna, MG. & Acevedo-Arozena, A. (2014). 'Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis'. Brain, vol 137, no. 12, pp. 3171-3185. DOI: [ONLINE] DOI: 10.1093/BRAIN/AWU292 [ONLINE] AURA: 3171.FULL.PDF