Hold, Georgina - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

BSc (Hons) (University of Surrey, Guildford), PhD (University of Glasgow), Georgina Hold graduated from the University of Surrey in 1995 with an upper second class honours degree in Biochemistry/Toxicology. She moved to the University of Glasgow in the Division of Infection and Immunity, studying the role of bacteria in paralytic shellfish poisoning. After gaining her PhD in 1999, Dr Hold continued to study microbial diversity, but switched her attention to studying microbial relationships within the gastrointestinal tract, working in the Gut Microbiology Group at the Rowett Research Institute. In 2001, Dr Hold moved to the University of Aberdeen to become involved in the development of the new Gastroenterology (GI) research group within the Division of Applied Medicine. The overall objective in her research is to understand the impact of gastrointestinal microbes in human diseases. In particular, understanding the interactions between resident microbes and their host and how changes in the microbiota impact on human health. Developing greater understanding in this area will allow us to further appreciate the contribution that gut microbes play in diseases and potentially develop therapeutic strategies to maintain healthy microbial consortia. Since 2006, the focus has been on understanding the impact of the intestinal microbiota on chronic inflammatory disease processes of the human colon. This programme was established due to the unusually high incidence of both colorectal cancer and inflammatory bowel disease (IBD) within the North East of Scotland. Both of these diseases have a strong microbial involvement. Her research has a strongly collaborative flavour and she works with several national and international research collaborators. At present she has over 80 publications that are published or in press and Georgina is regularly invited to give conference and institutional lectures and expert opinion on my area of research. Georgina was awarded a Fulbright scholarship in 2014 – 2015 which was undertaken at Harvard T. H. Chan School of Public Health where she retains an honorary appointment.

研究领域

Dr Georgina Holds main research interest is in microbially induced chronic inflammation.

近期论文

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Mukhopadhya, I., Murdoch, H., Berry, S., Hunt, A., Iturriza-Gomara, M., Smith-Palmer, A., Cameron, JC. & Hold, GL. (2017). 'Changing molecular epidemiology of rotavirus infection after introduction of monovalent rotavirus vaccination in Scotland'. Vaccine, vol 35, no. 1, pp. 156-163. DOI: [ONLINE] DOI: 10.1016/J.VACCINE.2016.11.028 Watt, E., Gemmell, MR., Berry, S., Glaire, M., Farquharson, F., Louis, P., Murray, GI., El-Omar, E. & Hold, GL. (2016). 'Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies'. Microbiome, vol 4, 61. DOI: [ONLINE] DOI: 10.1186/S40168-016-0207-9 [ONLINE] AURA: EXTENDING_COLONIC_MUCOSAL_MICROBIOME_ANALYSIS_ASSESSMENT_OF_... Mukhopadhya, I., Murray, GI., Duncan, L., Yuecel, R., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E., Hold, G. & Hijazi, K. (2016). 'Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T cells: Implications for HIV Microbicides'. Molecular Pharmaceutics, vol 13, no. 9, pp. 3334-3340. DOI: [ONLINE] DOI: 10.1021/ACS.MOLPHARMACEUT.6B00351 Hold, GL. (2016). 'Gastrointestinal Microbiota and Colon Cancer'. Digestive Diseases and Sciences, vol 34, no. 3, pp. 244-250. DOI: [ONLINE] DOI: 10.1159/000443358 Mukhopadhya, I., Murray, GI., Berry, S., Thomson, J., Frank, B., Gwozdz, G., Ekeruche-Makinde, J., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, EMA.-G, Hold, GL. & Hijazi, K. (2016). 'Drug Transporter Gene Expression in Human Colorectal Tissue and Cell Lines: Modulation with Antiretrovirals for Microbicide Optimization'. Journal of Antimicrobial Chemotherapy, vol 71, no. 2, pp. 372-386. DOI: [ONLINE] DOI: 10.1093/JAC/DKV335 [ONLINE] AURA: MANUSCRIPT_TABLES_FIGURES_MUKHOPADHYA_ET_AL_V2.DOCX Marchesi, JR., Adams, DH., Fava, F., Hermes, GDA., Hirschfield, GM., Hold, G., Quraishi, MN., Kinross, J., Smidt, H., Tuohy, KM., Thomas, LV., Zoetendal, EG. & Hart, A. (2016). 'The gut microbiota and host health: a new clinical frontier'. Gut, vol 65, no. 2, pp. 330-339. DOI: [ONLINE] DOI: 10.1136/GUTJNL-2015-309990 [ONLINE] AURA: GUT_2016_MARCHESI_330_9.PDF Hansen, R., Scott, KP., Khan, S., Martin, JC., Berry, SH., Stevenson, M., Okpapi, A., Munro, MJ. & Hold, GL. (2015). 'First-Pass Meconium Samples from Healthy Term Vaginally-Delivered Neonates: An Analysis of the Microbiota'. PloS one, vol 10, no. 7, e0133320. DOI:[ONLINE] DOI: 10.1371/JOURNAL.PONE.0133320 [ONLINE] AURA: JOURNAL.PONE.0133320.PDF Basavaraju, U., Shebl, FM., Palmer, AJ., Berry, S., Hold, GL., El-Omar, EM. & Rabkin, CS. (2015). 'Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland'. European Journal of Cancer Prevention, vol 24, no. 4, pp. 296-304. DOI: [ONLINE] DOI: 10.1097/CEJ.0000000000000087 Hijazi, K., Cuppone, AM., Smith, K., Stincarelli, MA., Ekeruche-Makinde, J., De Falco, G., Hold, GL., Shattock, R., Kelly, CG., Pozzi, G. & Iannelli, F. (2015). 'Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral Drugs'. PloS one, vol 10, no. 6, e0131405. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0131405 [ONLINE] AURA: JOURNAL.PONE.0131405.PDF Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, JM., Russell, RK., Berry, SH., El-Omar, EM. & Hold, GL. (2015). 'The fungal microbiota of de-novo paediatric inflammatory bowel disease'. Microbes and Infection, vol 17, no. 4, pp. 304-310. DOI: [ONLINE] DOI: 10.1016/J.MICINF.2014.12.001 [ONLINE] AURA: 1_S2.0_S1286457914003074_MAIN.PDF