Hijazi, Karolin - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

I graduated from the University of Siena in 2004 with cum laude distinction. During my dental undergraduate programme I trained in molecular microbiology and developed a special interest for host-microbe interactions. After completing a PhD in Pathology at King’s College London in 2008, I worked as post-doctoral research associate and continued my involvement in 3 European Commission-funded projects (Research Programs FP6 and FP7) aimed at developing anti-HIV-1 microbicides. During this time I was also trained in management of patients with Oral Medicine-related conditions at King’s College London Dental Institute. Since my appointment to Clinical Lecturer at the University of Aberdeen Dental School in 2011, I have secured research funds in excess of ￡ 550,000 for 4 projects in which I am the principal investigator. I am also involved in a number of external and internal collaborations. Collaborators here at the University of Aberdeen include Professor Neil Gow, Dr Ian M Gould. I currently supervise 2 PhD students. My research covers both basic and translational aspects. It includes investigation of molecular mechanisms of HIV infection and drug transport at mucosal surfaces, studies on oral microbiota together with development of inhibitors of infection as well as approaches to manipulate mucosal microbiota. I have received awards for my research at both national (British Society for Oral Medicine) and international (Microbicides 2006) scientific conferences. I has been invited to give research seminars at a number prestigious institutions including Imperial College London, University College London and Glasgow University.

研究领域

Karolin Hijazi’s main research focus is the development of microbicides against HIV-1. Microbicides are inhibitors of viral attachment, fusion or replication that can be applied directly to mucosal tissues to prevent transmission of HIV. More generally, Karolin Hijazi is interested in the role of microbiota and host response in etiology and pathogenesis of mucosal diseases, and also the development of agents for modulation of host-microbe interaction at mucosal surfaces. As research fellow at the University of Siena Karolin Hijazi was involved in EC and NIH-funded research programs aimed at analyzing attachment receptors and potential virulence factors of Streptococcus gordonii and use of this microorganism as a mucosal delivery vehicle for vaccine antigens and inhibitors. Research activities at King’s College London included investigation of the role of DC-SIGN receptor in dendritic cell-mediated transmission of HIV.

近期论文

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Moorhouse, A., Hijazi, K. & Gow, NAR. (in press). 'Multilocus sequence typing (MLST) of Candida .spp isolates from the Oral Cavity Reveals Strain Persistence and Clonality within and between niches from Dental Patients and Healthy Control Subjects'. n/a. Mukhopadhya, I., Murray, GI., Duncan, L., Yuecel, R., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E., Hold, G. & Hijazi, K. (2016). 'Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T cells: Implications for HIV Microbicides'. Molecular Pharmaceutics, vol 13, no. 9, pp. 3334-3340. DOI: [ONLINE] DOI: 10.1021/ACS.MOLPHARMACEUT.6B00351 Hijazi, K., Mukhopadhya, I., Abbott, F., Milne, K., Al-Jabri, ZJ., Oggioni, MR. & Gould, IM. (2016). 'Susceptibility to chlorhexidine amongst multidrug-resistant clinical isolates of Staphylococcus epidermidis from bloodstream infections'. International Journal of Antimicrobial Agents, vol 48, no. 1, pp. 86-90. DOI: [ONLINE] DOI: 10.1016/J.IJANTIMICAG.2016.04.015 Mukhopadhya, I., Murray, GI., Berry, S., Thomson, J., Frank, B., Gwozdz, G., Ekeruche-Makinde, J., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, EMA.-G, Hold, GL. & Hijazi, K. (2016). 'Drug Transporter Gene Expression in Human Colorectal Tissue and Cell Lines: Modulation with Antiretrovirals for Microbicide Optimization'. Journal of Antimicrobial Chemotherapy, vol 71, no. 2, pp. 372-386. DOI: [ONLINE] DOI: 10.1093/JAC/DKV335 [ONLINE] AURA: MANUSCRIPT_TABLES_FIGURES_MUKHOPADHYA_ET_AL_V2.DOCX Foley, JI. & Hijazi, K. (2015). 'Predictive value of the admissions process and the UK Clinical Aptitude Test in a graduate-entry dental school'. British Dental Journal, vol 218, no. 12, pp. 687-689. DOI: [ONLINE] DOI: 10.1038/SJ.BDJ.2015.437 Hijazi, K., Cuppone, AM., Smith, K., Stincarelli, MA., Ekeruche-Makinde, J., De Falco, G., Hold, GL., Shattock, R., Kelly, CG., Pozzi, G. & Iannelli, F. (2015). 'Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral Drugs'. PloS one, vol 10, no. 6, e0131405. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0131405 [ONLINE] AURA: JOURNAL.PONE.0131405.PDF Hijazi, K., Lowe, T., Meharg, C., Berry, SH., Foley, J. & Hold, GL. (2015). 'Mucosal microbiome in patients with recurrent aphthous stomatitis'. Journal of Dental Research, vol 94, no. 3 Suppl.1, pp. 87S-94S. DOI: [ONLINE] DOI: 10.1177/0022034514565458 Smith, KA., Mukhopadhya, I., Berry, S., Hold, GL. & Hijazi, K. (2014). 'Expression of Drug Transporters in Cervicovaginal Cell Lines and Modulatory Effect of Candidate Anti-retroviral Microbicides'. AIDS Research and Human Retroviruses, vol 30, no. Suppl 1, P31.02, pp. A201. DOI: [ONLINE] DOI: 10.1089/AID.2014.5434.ABSTRACT Foley, JI. & Hijazi, K. (2013). 'The admissions process in a graduate-entry dental school: can we predict academic performance?'. British Dental Journal, vol 214, no. 2, E4. DOI: [ONLINE] DOI: 10.1038/SJ.BDJ.2013.56 Hijazi, K., Wang, Y., Scala, C., Jeffs, S., Longstaff, C., Stieh, D., Haggarty, B., Vanham, G., Schols, D., Balzarini, J., Jones, IM., Hoxie, J., Shattock, R. & Kelly, CG. (2011). 'DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4'. PloS one, vol 6, no. 12, e28307. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0028307 [ONLINE] AURA: PONE.0028307.PDF