Fleming, Ian - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

研究领域

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells. Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

近期论文

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Phyu, SM., Tseng, C-CT, Fleming, IN. & Smith, TAD. (2016). 'Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3'. Scientific Reports, vol 6, 36544. DOI: [ONLINE] DOI: 10.1038/SREP36544 [ONLINE] AURA: SREP36544.PDF Zhang, Q., Dall'Angelo, S., Fleming, IN., Schweiger, LF., Zanda, M. & O'Hagan, D. (2016). 'Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers'. Chemistry : a European Journal, vol 22, no. 31, pp. 10998-11004. DOI: [ONLINE] DOI: 10.1002/CHEM.201601361 Graziadio, A., Zanda, M., Frau, S., Fleming, IN., Musolino, M., Dall'Angelo, S., Baldassarre, M. & Piras, M. (2016). 'NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting'. Bioconjugate Chemistry, vol 27, no. 5, pp. 1332-1340. DOI: [ONLINE] DOI: 10.1021/ACS.BIOCONJCHEM.6B00136 Thompson, S., Fleming, IN. & O’Hagan, D. (2016). 'Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase'. Organic & Biomolecular Chemistry, vol 14, no. 11, pp. 3120-3129. DOI: [ONLINE] DOI: 10.1039/C6OB00239K [ONLINE] AURA: ENZYMATIC_TRANSHALOGENATION_OF_DENDRITIC_RGD_PEPTIDE_CONSTRU... Thompson, S., Onega, M., Ashworth, S., Fleming, IN., Passchier, J. & O'Hagan, D. (2015). 'A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography'. Chemical Communications, vol 51, no. 70, pp. 13542-13545. DOI: [ONLINE] DOI: 10.1039/C5CC05013H [ONLINE] AURA: MANUSCRIPT_MODIFIED_15_JUL_REVISED.DOCX Lamidi, O., Sani, M., Lazzari, P., Zanda, M. & Fleming, IN. (2015). 'The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2'. Journal of Cancer Research and Clinical Oncology, vol 141, no. 9, pp. 1575-1583. DOI: [ONLINE] DOI: 10.1007/S00432-015-1921-6 Cooper, AC., Fleming, IN., Phyu, SM. & Smith, TAD. (2015). 'Changes in [18F]Fluoro-2-deoxy-D-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling'. Journal of Cancer Research and Clinical Oncology, vol 141, no. 9, pp. 1523-1532. DOI: [ONLINE] DOI: 10.1007/S00432-015-1909-2 [ONLINE] AURA: METFORMINPAPER_CRCO.DOCX Nortcliffe, A., Fleming, IN., Botting, NP. & O'Hagan, D. (2014). 'Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone'. Tetrahedron, vol 70, no. 44, pp. 8343-8347. DOI: [ONLINE] DOI: 10.1016/J.TET.2014.09.004 Thompson, S., Zhang, Q., Onega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, JH., Passchier, J. & O'Hagan, D. (2014). 'A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions'. Angewandte Chemie International Edition, vol 53, no. 34, pp. 8913-8918. DOI: [ONLINE] DOI: 10.1002/ANIE.201403345 Fleming, IN., Andriu, A. & Smith, TAD. (2014). 'Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α'. Breast Cancer Research and Treatment, vol 144, no. 4, pp. 241-248. DOI: [ONLINE] DOI: 10.1007/S10549-014-2858-1 [ONLINE] AURA: AKTINPAPERBCRT.DOCX [ONLINE] AURA: AKTINPAPERBCRT.DOCX