Docherty, Kevin - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Kevin Docherty graduated with a BSc in Biochemistry from St Andrews in 1974. He did his PhD in Edinburgh (1979) and then moved to a post-doc in Cambridge (1978-1980), where he worked on sugar transport mechanisms. He did a second post-doc (1980-1982) at the University of Chicago working on proinsulin biosynthesis and processing. He returned to the UK to a lectureship (1983-1985) in the Department of Medicine at the University of Birmingham. He was promoted to Senior Lecturer in 1985 and Reader in Molecular Endocrinology in 1989. He moved to the MacLeod Smith Chair in Biochemistry at the University of Aberdeen in 1994. He was Head of the Department of Molecular and Cell Biology from 1999-2003. He has served on the editorial board of: Molecular and Cellular Endocrinology (2000- ); Journal of Molecular Endocrinology (1988 - ); and The Biochemical Journal (1994-2000). He has also served on several grant-awarding committees: British Diabetic Association (1991-1994); Novo Nordisk UK Grant (1992-1999); and Juvenile Diabetes Research Foundation Medical and Scientific Grants Committee (2000-2003 and 2004- ).

研究领域

Biology of the islets of Langerhans with particular interest in transcription factors that regulate islet gene expression and development

近期论文

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Mazzotta, S., Neves, C., Bonner, RJ., Bernardo, AS., Docherty, K. & Hoppler, S. (2016). 'Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development'. Stem cell reports, vol 7, no. 4, pp. 764-776. DOI: [ONLINE] DOI: 10.1016/J.STEMCR.2016.08.008 [ONLINE] AURA: 1_S2.0_S2213671116301758_MAIN.PDF Lima, MJ., Muir, KR., Docherty, HM., McGowan, NWA., Forbes, S., Heremans, Y., Heimberg, H., Casey, J. & Docherty, K. (2016). 'Generation of Functional Beta-Like Cells from Human Exocrine Pancreas'. PloS one, vol 11, no. 5, e0156204. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0156204 [ONLINE] AURA: JOURNAL.PONE.0156204.PDF Muir, KR., Lima, MJ., Docherty, HM., McGowan, NWA., Forbes, S., Heremans, Y., Forbes, SJ., Heimberg, H., Casey, J. & Docherty, K. (2015). 'Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture'. PloS one, vol 10, no. 10, e0140352. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0140352 [ONLINE] AURA: JOURNAL.PONE.0140352.PDF Forbes, S., McGowan, NWA., Duncan, K., Anderson, D., Barclay, J., Mitchell, D., Docherty, K., Turner, D., Campbell, JDM. & Casey, JJ. (2015). 'Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes'. Diabetologia, vol 58, no. 6, pp. 1300-1308. DOI: [ONLINE] DOI: 10.1007/S00125-015-3554-3 [ONLINE] AURA: ART_3A10.1007_2FS00125_015_3554_3.PDF Muir, KR., Lima, MJ., Docherty, HM. & Docherty, K. (2014). 'Cell Therapy for Type 1 Diabetes'. QJM, vol 107, no. 4, pp. 253-259. DOI: [ONLINE] DOI: 10.1093/QJMED/HCU025 [ONLINE] AURA: 253.FULL.PDF Allan, J., Fraser, RM., Owen-Hughes, T., Docherty, K. & Singh, V. (2013). 'A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones'. Journal of Molecular Biology, vol 425, no. 22, pp. 4206-4222. DOI: [ONLINE] DOI: 10.1016/J.JMB.2013.07.019 [ONLINE] AURA: A_COMPARISON_OF_IN_VITRO_NUCLEOSOME.PDF Lima, MJ., Muir, KR., Docherty, HM., Drummond, R., McGowan, NWA., Heremans, Y., Forbes, S., Houbracken, I., Ross, JA., Forbes, SJ., Ravassard, P., Heimberg, H., Casey, J. & Docherty, K. (2013). 'Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells'. Diabetes, vol 62, no. 8, pp. 2821-2833. DOI: [ONLINE] DOI: 10.2337/DB12-1256 Cho, CH.-H, Hannan, NR.-F, Docherty, FM., Docherty, HM., Lima, MJ., Trotter, MWB., Docherty, K. & Vallier, L. (2012). 'Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells'. Diabetologia, vol 55, no. 12, pp. 3284-3295. DOI: [ONLINE] DOI: 10.1007/S00125-012-2687-X [ONLINE] AURA: CHO_ET_AL_2012.PDF Lima, MJ., Docherty, H., Chen, Y. & Docherty, K. (2012). 'Efficient Differentiation of AR42J Cells towards Insulin-Producing Cells using Pancreatic Transcription Factors in Combination with Growth Factors'. Molecular and Cellular Endocrinology, vol 358, no. 1, pp. 69-80. DOI:[ONLINE] DOI: 10.1016/J.MCE.2012.02.024 Lima, MJ., Docherty, HM., Chen, Y., Vallier, L. & Docherty, K. (2012). 'Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas'. PLoS ONE, vol 7, no. 5, e36481. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0036481 [ONLINE] AURA: PANCREATIC_TRANSCRIPTION.PDF