Bari, Cosimo De - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Cosimo graduated in Medicine (maxima cum laude) from the University of Bari (Italy), where he also underwent specialist training in Rheumatology. He then moved to Belgium, where he obtained his PhD from the Catholic University of Leuven and was recipient of the Rotary Young Investigator Award 2003 from the Royal Belgian Society for Rheumatology. In 2003 Cosimo moved to the UK in the Department of Rheumatology at King's College London. In May 2005 he was awarded a Clinician Scientist Fellowship from the Medical Research Council and in December 2005 he was appointed Clinical Senior Lecturer & Consultant Rheumatologist. Since September 2007 Cosimo is Professor of Translational Medicine at the University of Aberdeen, where he heads the Arthritis and Regenerative Medicine Laboratory

研究领域

The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas. The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic. The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.

近期论文

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Ansboro, S., Roelofs, AJ. & de Bari, C. (2017). 'Mesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?'. Current Opinion in Rheumatology, vol 29, no. 2, pp. 201-207. DOI: [ONLINE] DOI: 10.1097/BOR.0000000000000370 Sergijenko, A., Roelofs, AJ., Riemen, AHK. & De Bari, C. (2016). 'Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury'. Arthritis Research & Therapy, vol 18, 166. DOI: [ONLINE] DOI: 10.1186/S13075-016-1060-8 Redelinghuys, P., Whitehead, L., Augello, A., Drummond, RA., Levesque, J-M, Vautier, S., Reid, DM., Kerscher, B., Taylor, JA., Nigrovic, PA., Wright, J., Murray, GI., Willment, JA., Hocking-Mennie, LJ., Fernandes, MJ., De Bari, C., McInnes, IB. & Brown, GD. (2016). 'MICL controls inflammation in rheumatoid arthritis'. Annals of the Rheumatic Diseases, vol 75, no. 7, pp. 1386-1391. DOI: [ONLINE] DOI: 10.1136/ANNRHEUMDIS-2014-206644 [ONLINE] AURA: ANN_RHEUM_DIS_2016_REDELINGHUYS_1386_91.PDF Karystinou, A., Roelofs, AJ., Neve, A., Cantatore, FP., Wackerhage, H. & De Bari, C. (2015). 'Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells'. Arthritis Research & Therapy, vol 17, 147. DOI: [ONLINE] DOI: 10.1186/S13075-015-0639-9 [ONLINE] AURA: S13075_015_0639_9.PDF Eseonu, OI. & De Bari, C. (2015). 'Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis'. Rheumatology, vol 54, no. 2, pp. 210-218. DOI: [ONLINE] DOI: 10.1093/RHEUMATOLOGY/KEU377 Sherwood, J., Bertrand, J., Nalesso, G., Poulet, B., Pitsillides, A., Brandolini, L., Karystinou, A., De Bari, C., Luyten, FP., Pitzalis, C., Pap, T. & Dell'Accio, F. (2015). 'A homeostatic function of CXCR2 signalling in articular cartilage'. Annals of the Rheumatic Diseases, vol 74, no. 12, pp. 2207-2215. DOI: [ONLINE] DOI: 10.1136/ANNRHEUMDIS-2014-205546 [ONLINE] AURA: ANN_RHEUM_DIS_2015_SHERWOOD_2207_15.PDF Marcus, P., De Bari, C., Dell'Accio, F. & Archer, CW. (2014). 'Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice'. Cartilage, vol 5, no. 4, pp. 231-240. DOI: [ONLINE] DOI: 10.1177/1947603514541274 [LINK] HTTP://CAR.SAGEPUB.COM/CONTENT/5/4/231.FULL Tremblay, AM., Missiaglia, E., Galli, GG., Hettmer, S., Urcia, R., Carrara, M., Judson, RN., Thway, K., Nadal, G., Selfe, JL., Murray, GI., Calogero, RA., De Bari, C., Zammit, PS., Delorenzi, M., Wagers, AJ., Shipley, J., Wackerhage, H. & Camargo, FD. (2014). 'The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation'. Cancer Cell, vol 26, no. 2, pp. 273-287. DOI: [ONLINE] DOI: 10.1016/J.CCR.2014.05.029 Cherry, HM., Roelofs, AJ., Kurth, T. & De Bari, C. (2014). 'In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum'. European Cells & Materials, vol 27, pp. 185-195. [ONLINE] AURA: CHERRY_ET_AL_ECM_2014.PDF [LINK] HTTP://WWW.ECMJOURNAL.ORG/JOURNAL/PAPERS/VOL027/VOL027A14.PHP Gullo, F. & De Bari, C. (2013). 'Prospective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency'. Rheumatology, vol 52, no. 10, pp. 1758-1768.