Crane, Isabel - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Isabel Crane graduated from the University of London with a first class honours degree in Genetics and Microbiology in 1978 and with a PhD in Genetics in 1982. Her interest in Immunology also began in 1982 with a postdoctoral research appointment at the National Institute for Biological Standards and Control, London, working on Interferon gamma. In 1984 she moved to a research post at the University of Bristol, becoming Wellcome Trust Lecturer in Immunology from 1986 to 1990. She joined the Department of Ophthalmology at Aberdeen University in 1995 where she began a research programme to investigate the role of chemokines in the passage of inflammatory cells across the blood-retina barrier. She was appointed Saving Sight in Grampian Lecturer in Immunology in 2003 and Senior Lecturer in 2007

研究领域

Research interests centre around the role of chemokines and their receptors, and adhesion molecules, in leukocyte trafficking with particular focus on recruitment to the inflamed retina.

近期论文

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Devarajan, G., Niven, J., Forrester, JV. & Crane, IJ. (2016). 'Retinal Pigment Epithelial Cell Apoptosis is Influenced by a Combination of Macrophages and Soluble Mediators Present in Age-Related Macular Degeneration'. Current Eye Research, vol 41, no. 9, pp. 1235-1244. DOI: [ONLINE] DOI: 10.3109/02713683.2015.1109129 Niven, J., Hoare, J., McGowan, D., Devarajan, G., Itohara, S., Gannagé, M., Teismann, P. & Crane, I. (2015). 'S100B up-regulates macrophage production of IL1β and CCL22 and influences severity of retinal inflammation'. PLoS ONE, vol 10, no. 7, e0132688. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0132688 [ONLINE] AURA: JOURNAL.PONE.0132688.PDF Wallace, CA., Moir, G., Malone, DFG., Duncan, L., Devarajan, G. & Crane, IJ. (2013). 'Regulation of T-lymphocyte CCL3 and CCL4 production by retinal pigment epithelial cells'. Investigative Ophthalmology & Visual Science, vol 54, no. 1, pp. 722-730. DOI: [ONLINE] DOI: 10.1167/IOVS.12-10602 Dagkalis, A., Wallace, C., Xu, H., Liebau, S., Manivannan, A., Stone, MA., Mack, M., Liversidge, J. & Crane, IJ. (2009). 'Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2'. Investigative Ophthalmology & Visual Science, vol 50, no. 9, pp. 4288-4294. DOI: [ONLINE] DOI: 10.1167/IOVS.09-3434 Dagkalis, A., Wallace, C., Hing, B., Liversidge, J. & Crane, IJ. (2009). 'CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis'. Immunology, vol 128, no. 1, pp. 25-33. DOI: [ONLINE] DOI: 10.1111/J.1365-2567.2009.03046.X Xu, H., Manivannan, A., Crane, I., Dawson, R. & Liversidge, J. (2008). 'Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation'. Blood, vol 112, no. 4, pp. 1166-1174. DOI: [ONLINE] DOI: 10.1182/BLOOD-2007-06-098327 Ali, S., Jenkins, Y., Kirkley, M., Dagkalis, A., Manivannan, A., Crane, IJ. & Kirby, JA. (2008). 'Leukocyte extravasation: An immunoregulatory role for alpha-L-Fucosidase?'. The Journal of Immunology, vol 181, no. 4, pp. 2407-2413. Crane, IJ., Kuffova, L. & Forrester, JV. (2007). 'Challenges in the Treatment of Ocular Connective Tissue Diseases'. Ophthalmology - Current Medical Literature, vol 17, no. 4, pp. 113-24. Crane, IJ., Xu, H., Wallace, CA., Manivannan, A., Mack, M., Liversidge, JM., Marquez, G., Sharp, PF. & Forrester, JV. (2006). 'Involvement of CCR5 in the passage of Th-1-type cells across the blood-retina barrier in experimental autoimmune uveitis'. Journal of Leukocyte Biology, vol 79, no. 3, pp. 435-443. DOI: [ONLINE] DOI: 10.1189/JLB.0305130 Xu, H., Manivannan, A., Dawson, RA., Crane, IJ., Mack, M., Sharp, PF. & Liversidge, JM. (2005). 'Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time- limited property of blood monocytes and is independent of local inflammatory mediators'. The Journal of Immunology, vol 175, no. 10, pp. 6915-6923.