Connolly, Bernadette - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Personal Chair, Medical Sciences, University of Aberdeen (2013) Senior Lecturer in Medical Sciences, University of Aberdeen (2003) Lecturer in Molecular & Cell Biology, University of Aberdeen (1999) Molecular Parasitology: Marie-Heim Voegtlin Fellow, University of Bern, Switzerland (1997) Group Leader, Institute of Parasitology, University of Bern, Switzerland (1994-1999) Post-doctoral Researcher, Imperial College London (1990-1993) Genetics & Biochemistry of DNA Recombination: Post-doctoral Researcher, Imperial Cancer Research Fund (1987-1990) Post-doctoral Researcher, Brandeis University, Massachusetts (1983-1987) PhD (Genetics), Trinity College Dublin, Ireland (1984) BSc (Hons), NUI Maynooth, Ireland (1980)

研究领域

I am interested in the biology and evolution of nematodes, with a particular interest in parasitic species and understanding the molecular basis of the host-parasite interaction. My group studies Trichinella, a remarkable species of parasitic nematode both in terms of its choice of niche and in the strategies it has evolved to exploit that niche. The infective L1 larva is an intracellular parasite of mammalian skeletal muscle, remodelling the intracellular environment to create a niche for itself. On infection a realignment of host cell gene expression is induced that ultimately leads to dedifferentiation of the muscle cell and redifferentiation to a new cell type designed to support the parasite. The parasite itself may be involved in initiating these changes in the host cell, but the precise mechanism remains to be elucidated

近期论文

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Pettitt, J., Philippe, L., Sarkar, D., Johnston, C., Gothe, H., Massie, D., Connolly, B. & Muller, B. (2014). 'Operons Are a Conserved Feature of Nematode Genomes'. Genetics, vol 197, no. 4, pp. 1201-1211. DOI: [ONLINE] DOI: 10.1534/GENETICS.114.162875 [LINK] HTTP://WWW.GENETICS.ORG/CONTENT/197/4/1201.FULL Harrison, N., Kalbfleisch, A., Connolly, B., Pettitt, J. & Muller, B. (2010). 'SL2-like spliced leader RNAs in the basal nematode Prionchulus punctatus: new insight into the evolution of nematode SL2 RNAs'. RNA , vol 16, no. 8, pp. 1500-1507. DOI: [ONLINE] DOI: 10.1261/RNA.2155010 Pettitt, J., Harrison, N., Stansfield, I., Connolly, B. & Müller, B. (2010). 'The evolution of spliced leader trans-splicing in nematodes'. Biochemical Society Transactions, vol 38, no. 4, pp. 1125-1130. DOI: [ONLINE] DOI: 10.1042/BST0381125 Bolas-Fernandez, F., Dea-Ayuela, MA., Connolly, B. & Robinson, MW. (2009). 'Micro-environmental conditions modulate protein secretion and infectivity of the Trichinella spiralis L1 larva'. Veterinary Parasitology, vol 159, no. 3-4, pp. 236-239. DOI: [ONLINE] DOI: 10.1016/J.VETPAR.2008.10.049 Cwiklinski, K., Meskill, D., Robinson, MW., Pozio, E., Appleton, JA. & Connolly, B. (2009). 'Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene'. Veterinary Parasitology, vol 159, no. 3-4, pp. 268-271. DOI: [ONLINE] DOI: 10.1016/J.VETPAR.2008.10.036 Pettitt, J., Muller, BM., Stansfield, I. & Connolly, B. (2008). 'Spliced leader trans-splicing in the nematode Trichinella spiralis uses highly polymorphic, noncanonical spliced leaders'. RNA , vol 14, no. 4, pp. 760-770. DOI: [ONLINE] DOI: 10.1261/RNA.948008 Robinson, MW., Greig, R., Beattie, KA., Lamont, DJ. & Connolly, B. (2007). 'Comparative analysis of the excretory-secretory proteome of the muscle larva of Trichinella pseudospiralis and Trichinella spiralis'. International Journal for Parasitology, vol 37, no. 2, pp. 139-148. DOI: [ONLINE] DOI: 10.1016/J.IJPARA.2006.08.007 Robinson, MW., Massie, DH. & Connolly, B. (2007). 'Secretion and processing of a novel multi-domain cystatin-like protein by intracellular stages of Trichinella spiralis'. Molecular and Biochemical Parasitology, vol 151, no. 1, pp. 9-17. DOI: [ONLINE] DOI: 10.1016/J.MOLBIOPARA.2006.09.008 Robinson, MW. & Connolly, B. (2005). 'Proteomic analysis of the excretory-secretory proteins of the Trichinella spiralis L1 larva, a nematode parasite of skeletal muscle'. Proteomics, vol 5, no. 17, pp. 4525-4532. DOI: [ONLINE] DOI: 10.1002/PMIC.200402057 Robinson, MW., Gare, DC. & Connolly, B. (2005). 'Profiling excretory/secretory proteins of Trichinella spiralis muscle larvae by two-dimensional gel electrophoresis and mass spectrometry'. Veterinary Parasitology, vol 132, no. 1-2, pp. 37-41. DOI: [ONLINE] DOI: 10.1016/J.VETPAR.2005.05.019