Bewick, Guy - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

I graduated with a BSc in Zoology and Animal Physiology from the University of East Anglia in 1979. After 3 years working for the Ministry of Agriculture, Fisheries and Food inspecting export grain for insect infestation, I began my research career with a PhD position in the Department of Physiology, King’s College London with Dr David A Tonge. This initiated my research interest studying how appropriate nerve-muscle connections are made and then adapted to their diverse functions. I gained my PhD in 1986, investigating the regeneration of nerve-muscle connections. Subsequent postdoctoral work investigated other aspects of neuromuscular function. First, with Prof Glen Cottrell in St Andrews, investigating how simple (acetylcholine) and complex (neuropeptides) molecules, called 'neurotransmitters', are used simultaneously for neuromuscular signalling. Later, I worked in the Department of Physiology, University of Bristol with Dr Tony Ridge, studying the developmental pruning of nerve-muscle connections. This led to a major 2-year period at the University of Colorado Health Sciences Center, Denver, Colorado, USA. Here, with Dr Bill Betz, we developed technique for using FM1-43 and related dyes for fluorescent studies of the kinetics and distribution of the tiny neurotrnamsitter packets (vesicles) during activity in living nerve terminals. Between 1991 and 1994, I worked with Prof Clarke Slater in the Muscular Dystrophy Group Research Laboratories, Newcastle General Hospital investigating the role of muscular dystrophy-related structural proteins in building nerve-muscle specialisations. I was appointed to a Lectureship in Biomedical Sciences, University of Aberdeen, in 1994 and promoted to Senior Lecturer in 2001.

研究领域

Dr Bewick’s research interests are centred on understanding how appropriate nerve-muscle signalling is established and maintained, both in motor and sensory systems. One focus is elucidating the role of the intriguing system of synaptic-like vesicles in mechanically sensitive sensory endings, he uncovered in collaboration with Dr Robert Banks of Durham University. This vesicle-based system seems to regulate the excitability of these sensory endings over a wide range, and is even capable of turning off the ending entirely. The other focus is on the neuromuscular junction, where he is examining how transmitter release from the motor terminal is maintained over a range of in vivo activity patterns. As well as understanding the basic neuroscience, he is exploring these control mechanisms as potential targets for strategies to ameliorate weakness in neuromuscular diseases

近期论文

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Lin, S-H, Cheng, Y-R, Banks, RW., Min, M-Y, Bewick, GS. & Chen, C-C (2016). 'Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors'. Nature communications, vol 7, 11460. DOI: [ONLINE] DOI: 10.1038/NCOMMS11460 [ONLINE] AURA: NCOMMS11460.PDF [LINK] HTTP://F1000.COM/PRIME/726345293?BD=1 Bewick, GS., Cahusac, PMB. & Banks, RW. (2016). 'Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings'. Journal of visualized experiments : JoVE, vol 111, e53854. DOI: [ONLINE] DOI: 10.3791/53854 [ONLINE] AURA: JOVE_PROTOCOL_53854_COMBINED_RECORDING_MECHANICALLY_STIMULAT... [ONLINE] AURA: JOVE_MATERIALS_53855_OPTICAL_MONITORING_LIVING_NERVE_TERMINA... Bewick, GS. & Banks, RW. (2016). 'Optical Monitoring of Living Nerve Terminal Labeling in Hair Follicle Lanceolate Endings of the Ex Vivo Mouse Ear Skin'. Journal of visualized experiments : JoVE, vol 110, e53855. DOI: [ONLINE] DOI: 10.3791/53855 [ONLINE] AURA: JOVE_PROTOCOL_53855_OPTICAL_MONITORING_LIVING_NERVE_TERMINAL... [ONLINE] AURA: JOVE_MATERIALS_53855_OPTICAL_MONITORING_LIVING_NERVE_TERMINA... Song, Z., Banks, RW. & Bewick, GS. (2015). 'Modelling the mechanoreceptor’s dynamic behaviour'. Journal of Anatomy, vol 227, no. 2, pp. 243-254. DOI: [ONLINE] DOI: 10.1111/JOA.12328 [ONLINE] AURA: SONG_ET_AL_2015_JOURNAL_OF_ANATOMY Bewick, GS. (2015). 'Synaptic-like vesicles and candidate transduction channels in mechanosensory terminals'. Journal of Anatomy, vol 227, no. 2, pp. 194-213. DOI: [ONLINE] DOI: 10.1111/JOA.12337 [ONLINE] AURA: BEWICK_2015_JOURNAL_OF_ANATOMY Bewick, G., Durbaba, R. & Pyner, S. (2015). '?Something old, something new, something borrowed, something .... else”: A symposium to mark the contribution of Robert W. Banks to the ?eld of mechanosensory neuroscience'. Journal of Anatomy, vol 227, no. 2, pp. 103. DOI: [ONLINE] DOI: 10.1111/JOA.12346 J Suslak, T., Watson, S., Thompson, KJ., Shenton, FC., Bewick, GS., Armstrong, JD. & Jarman, AP. (2015). 'Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons'. PLoS ONE, vol 10, no. 7, 0130969. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0130969 [ONLINE] AURA: PIEZO.PDF de Nooij, JC., Simon, CM., Simon, A., Doobar, S., Steel, KP., Banks, RW., Mentis, GZ., Bewick, GS. & Jessell, TM. (2015). 'The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors'. Journal of Neuroscience, vol 35, no. 7, pp. 3073-3084. DOI: [ONLINE] DOI: 10.1523/JNEUROSCI.3699-14.2015 [ONLINE] AURA: 3073.FULL.PDF Bewick, GS. & Banks, RW. (2015). 'Mechanotransduction in the muscle spindle'. Pflugers Archiv : European Journal of Physiology, vol 467, no. 1, pp. 175-190. DOI: [ONLINE] DOI: 10.1007/S00424-014-1536-9 [ONLINE] AURA: ART_3A10.1007_2FS00424_014_1536_9.PDF Zanato, C., Watson, S., Bewick, GS., Harrison, WTA. & Zanda, M. (2014). 'Synthesis and biological evaluation of (-)-kainic acid analogues as phospholipase D-coupled metabotropic glutamate receptor ligands'. Organic & Biomolecular Chemistry, vol 12, no. 47, pp. 9638-9643. DOI: [ONLINE] DOI: 10.1039/C4OB02002B