Barker, Robert - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Professor Barker qualified as a veterinary surgeon from the University of Bristol, where he first became attracted to immunology while undertaking an intercalated degree in cellular pathology. After a period in general practice he returned to academia, gaining a PhD in autoimmune disease from the University of Bristol. His interest in immunology developed further with the award of a Wellcome Trust Fellowship, which allowed him to exploit a unique approach to the study of immune-mediated diseases, using red blood cells as model target antigens. In 1996, Professor Barker accepted a Lectureship in Aberdeen and was promoted to Senior Lecturer in 2000, to Reader in 2003, and now holds a personal Chair in Immunology. He has served as Head of the Immunology Research Programme and Deputy Director of the Institute of Medical Sciences, and now leads the Immune Regulation Research Group. Professor Barker is currently a Trustee of the British Society for Immunology; the Groups' Secretary of the British Society for Immunology; a British Society for Immunology Autoimmunity Affinity Group Committee Member; a British Society for Immunology Regional Group Chair (Aberdeen Immunology Group); and a Scottish Immunology Group committee member. In the past he has served as Chair of the British Society for Immunology Council; a British Society for Immunology Journals Committee Member; a British Society for Immunology Meetings Committee member; a director of Triangle 3 (British Society for Immunology Trading Company); and has represented the British Society for Immunology at the International Union of Immunological Societies Council. He has also served as a member of the Research Committee of the Arthritis and Rheumatism Campaign; a member of the Editorial Board of the Open Pathology Journal; a member of the Association for Comparative Haematology; and is a member of the Royal College of Veterinary Surgeons.

研究领域

Since arriving in Aberdeen as lecturer in immunology in 1996, he has extended the approach to the study of immune-mediated diseases, using red blood cells as model target antigens to further understanding of the pathogenesis of a number of diseases in which the immune system plays an important role, including autoimmune haemolytic anaemia; haemolytic disease of the newborn; immune-mediated thrombocytopenia; Goodpasture’s disease; bullous skin diseases; atopy and asthma; viral and tumour immune evasion. The aim is to be able to control these diseases by manipulating immune regulation, particularly as mediated by regulatory T lymphocytes, and a number of projects are now undergoing commercial development for human trials.

近期论文

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Farhan, RK., Vickers, MA., Ghaemmagham, AM., Hall, AM., Barker, RN. & Walsh, GM. (2016). 'Effective antigen presentation to helper T cells by human eosinophils'. Immunology, vol 149, no. 4, pp. 413-422. DOI: [ONLINE] DOI: 10.1111/IMM.12658 Dahal, LN., Basu, N., Youssef, H., Khanolkar, RC., Barker, RN., Erwig, LP. & Ward, FJ. (2016). 'Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus'. Arthritis Research & Therapy, vol 18, 180, pp. 1-11. DOI: [ONLINE] DOI: 10.1186/S13075-016-1075-1 [ONLINE] AURA: ART_3A10.1186_2FS13075_016_1075_1.PDF Hoare, JI., Rajnicek, AM., McCaig, CD., Barker, RN. & Wilson, HM. (2016). 'Electric fields are novel determinants of human macrophage functions'. Journal of Leukocyte Biology, vol 99, no. 6, pp. 1141-1151. DOI: [ONLINE] DOI: 10.1189/JLB.3A0815-390R Arnold, CE., Barker, RN. & Wilson, HM. (2016). 'Critical Role for Inflammatory Macrophages in Driving Antigen-dependent Th17 Cell Responses?'. Journal of Cytokine Biology, vol 1, no. 1, 105, pp. 1-3. DOI: [ONLINE] DOI: 10.4172/JCB.1000105 [ONLINE] AURA: CRITICAL_ROLE_FOR_INFLAMMATORY_MACROPHAGES_IN_DRIVING_ANTIGE... Pickford, WJ., Gudi, V., Haggart, AM., Lewis, BJ., Herriot, R., Barker, RN. & Ormerod, A. (2015). 'T Cell participation in autoreactivity to NC16a epitopes in Bullous Pemphigoid'. Clinical and Experimental Immunology, vol 180, no. 2, pp. 189-200. DOI: [ONLINE] DOI: 10.1111/CEI.12566 Arnold, CE., Gordon, P., Barker, RN. & Wilson, HM. (2015). 'The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses'. Immunobiology, vol 220, no. 1, pp. 10-19. DOI: [ONLINE] DOI: 10.1016/J.IMBIO.2014.09.022 [ONLINE] AURA: IMMUNOBIOLOGY.PDF Forrester, MA., Robertson, L., Bayoumi, N., Keavney, BD., Barker, RN. & Vickers, MA. (2014). 'Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A'. Clinical and Experimental Immunology, vol 178, no. 2, pp. 373-383. DOI: [ONLINE] DOI: 10.1111/CEI.12408 Ward, FJ., Dahal, LN., Khanolkar, RC., Shankar, SP. & Barker, RN. (2014). 'Targeting the alternatively spliced soluble isoform of CTLA-4: prospects for immunotherapy?'. Immunotherapy, vol 6, no. 10, pp. 1073-1084. DOI: [ONLINE] DOI: 10.2217/IMT.14.73 Whibley, N., Maccallum, DM., Vickers, MA., Zafreen, S., Waldmann, H., Hori, S., Gaffen, SL., Gow, NAR., Barker, RN. & Hall, AM. (2014). 'Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge'. European Journal of Immunology, vol 44, no. 4, pp. 1069-1083. DOI: [ONLINE] DOI: 10.1002/EJI.201343604 [ONLINE] AURA: EJI_WHIBLEY.PDF Hall, LS., Hall, AM., Pickford, W., Vickers, MA., Urbaniak, SJ. & Barker, RN. (2014). 'Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice'. Haematologica, vol 99, no. 3, pp. 588-596. DOI: [ONLINE] DOI: 10.3324/HAEMATOL.2012.082081