Cadagan, David - Staffordshire University - Department of Biological and Biomedical Sciences

研究领域

Continual mapping of diabetic and non-diabetic adipocyte pathways with focus on therapeutic targets for metabolic dysfunctions and obesity. Which currently include: Examining the molecular pathway of insulin and novel androgen steroidogenesis in diabetic adipocyte cultures through protein and gene expression as well as steroid secretion. ?? Examination into the effects of varied hormonal messengers on adipocyte steroidogenesis and differentiation. Following determination of the novel luteinising hormone (LH) receptors present in early stage pre adipocyte differentiation we are examining the effects of LH in adipocyte maturation and steroid synthesis including androgens and estrogens processing

近期论文

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2014 Cadagan, D. Towlson, C. 2014. The Molecular Mechanisms of LH Action within Female Adipocytes (Journal of Biomedical Science, Dec 2014) 2014 Cadagan, D. Khan, R. Amer, S. 2014 Female Adipocyte Androgen Synthesis and the Effects of Insulin. Molecular Genetics and Metabolism, (1) P254-263 2013 Cadagan, D. Merry, S. 2013 Circumvention of Inherent or Acquired Cytotoxic Drug Resistance In Vitro Using Combinations of Modulating Agents Culture. Anticancer Research Journal. 2013 33(10). P4381-4393 2013 Cadagan, D. Merry, S. Barrington, R. 2013 The Effects of Quercetin, Kaempferol and Galangin on the Proliferation of MCF-7 Breast Cancer Cells is Dependent on Flavonol Structure. The British Society of Cell Biology and The British Society of Experimental Biology. 2013 (29) 2012 Cadagan, D. Towlson, S. Merry, 2012 Regulation of Adipocyte Proliferation by Insulin and Luteinising Hormone. E-Journal of The British Pharmacological Society 2012. ISSN 1741-1157. 2011 Cadagan, D. Towlson, C. Khan, R. Amer, S. 2011 The influence of Luteinising Hormone on Adipocyte Proliferation in Women with and without Polycystic Ovarian Syndrome. The Royal College of Obstetrics and Gynaecology, Blair Bell Research Symposium. 2011 (20) 2011 Cadagan, D. Towlson, C. Khan, R. Amer, S. 2011 Progesterone Secretion in Adipocytes and Variations in Polycystic Ovarian Syndrome. 1st International Symposium on Advances in Human Metabolism Research 2011 Cadagan, D. Towlson, C. Khan, R. Amer, S. 2011 Variations in Proliferation of Adipocytes within Normal and Polycystic Ovarian Syndrome under the effect of Insulin. E-Journal of British Pharmacological Society. 2011 ISSN 1741-1157 2010 Cadagan, D. Warren, A. Khan, R. Amer, S 2010 An Alternate Endocrine Function in Adipocytes with possible associations to Polycystic Ovarian Syndrome. 9th Congress of the European Society of Gynaecology. 2011 (55)