Adams, Dave - Heriot-Watt University - Department of Chemistry

个人简介

HWU Life Sciences Interface Theme management team member EPS Undergraduate Studies Group Chemistry representative

近期论文

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Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator', N. J. Smith, R. J. Ward, L. A. Stoddart, B. D. Hudson, E. Kostenis, T. Ulven, J. C. Morris, C. Trankle, I. G. Tikhonova, D. R. Adams and G. Milligan, Mol. Pharmacol., 2011, in press (doi:10.1124/mol.110.070789). Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast', R. W. Allcock, H. Blakli, Z. Jiang, K. A. Johnston, K. M. Morgan, G. M. Rosair, K. Iwase, Y. Kohno and D. R. Adams, Bioorg. Med. Chem. Lett., 2011, 21, 3307. Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)', J. P. Day, B. Lindsay, T. Riddell, Z. Jiang, R. W. Allcock, A. Abraham, S. Sookup, F. Christian, J. Bogum, E. K. Martin, R. L. Rae, D. Anthony, G. M. Rosair, D. M. Houslay, E. Huston, G. S. Baillie, E. Klussmann, M. D. Houslay and D. R. Adams, J. Med. Chem., 2011, 54, 3331. Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the beta-agonist induced hypertrophic response in cardiac myocytes', Y. Y. Sin, H. V. Edwards, X. Li, J. P. Day, F. Christian, A. J. Dunlop, D. R. Adams, M. Zaccolo, M. D. Houslay and G. S. Baillie, J. Mol. Cell. Cardiol., 2011, 50, 872. Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase', P. A. Kiely, G. S. Baillie, R. Barrett, D. A. Buckley, D. R. Adams, M. D. Houslay and R. O'Connor, J. Biol. Chem., 2009, 284, 20263.