Meggers, Eric Leif - Philipps-Universität Marburg

个人简介

1995, Diploma in Chemistry (with honors), University of Bonn, Germany 1999, Ph.D. in Organic Chemistry (summar cum laude), University of Basel, Switzerland 2002-2007, Assistant Professor, University of Pennsylvania, USA Since 2007, Full Professor, Department of Chemistry, University of Marburg, Germany EDUCATION 1999 Ph.D. in Organic Chemistry (summa cum laude)Department of Chemistry, University of Basel, Switzerland Advisor of PhD thesis: Prof. Dr. Bernd Giese 1995 Diploma in Chemistry (mit Auszeichnung) Institute of Organic Chemistry, University of Bonn, Germany Advisor of Diploma thesis: Prof. Dr. Eberhard Steckhan CURRENT POSITION 2007–present Full Professor (W3), Department of Chemistry, University of Marburg, Germany PREVIOUS POSITIONS 2011–2016 Group Leader together with Prof. Lei Gong, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China 2007–2013 Adjunct Faculty Member, The Wistar Institute, Philadelphia, USA 2002–2007 Assistant Professor, Department of Chemistry, University of Pennsylvania,Philadelphia, USA 1999–2002 Postdoctoral Researcher, The Scripps Research Institute, La Jolla, USA (with Prof.Dr. Peter G. Schultz)

研究领域

Chiral-at-metal catalyst design Sustainable catalysis with iron Stereocontrolled organic photochemistry Stereocontrolled electrochemistry Enantioselective nitrene chemistry

近期论文

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Nitrene-Mediated Enantioselective Intramolecular Olefin Oxyamination to Access Chiral γ-Aminomethyl-γ-Lactones: X. Nie, C. W. Ritter, M. Hemming, S. I. Ivlev, X. Xie, S. Chen, E. Meggers, Angew. Chem. Int. Ed. 2023, accepted article. Photelectrochemical asymmetric dehydrogenative [2+2] cycloaddition between C-C single and double bonds via the activation of two C(sp3)-H bonds: P. Xing, S. I. Ivlev, E. Meggers, Nat. Catal. 2023, DOI: 10.1038/s41929-023-01050-y. Design of Stereogenic-at-Iron Catalysts with a (3+2+1)-Ligand Sphere: D. Baran, L. Hinterlang, S. I. Ivlev, E. Meggers, Eur. J. Inorg. Chem. 2023, e202300148. Enantioselective and Enantioconvergent Iron-Catalyzed C(sp3)-H Aminations to Chiral 2-Imidazolidinones: T. Cui, C.-X. Ye, J. Thelemann, D. Jenisch, E. Meggers, Chin. J. Chem. 2023, 41, 2065-2070 (NHU-CJC Award). N-Boc-Protected α-Amino Acids by 1,3-Migratory Nitrene C(sp3)-H Insertion: B. Zhou; C.-X. Ye, E. Meggers, Eur. J. Org. Chem. 2023, doi.org/10.1002/ejoc.202300296. Trading Symmetry for Stereoinduction in Tetradentate, non-C2-Symmetric Fe(II)-Complexes for Asymmetric Catalysis: P. S. Steinlandt, M. Hemming, X. Xie, S. I. Ivlev, E. Meggers, Chem. Eur. J. 2023, e202300267. Chiral-at-Ruthenium Catalysts for Nitrene-Mediated Asymmetric C-H Functionalizations: C.-X. Ye, E. Meggers, Acc. Chem. Res. 2023, 56, 1128-1141. Metal Stereogenicity in Asymmetric Transition Metal Catalysis: P. S. Steinlandt, L. Zhang, E. Meggers, Chem. Rev. 2023, 123, 4764-4794. Expedited synthesis of α-amino acids by single-step enantioselective a-amination of carboxylic acids: C.-X. Ye, D. R. Dansby, S. Chen, E. Meggers, Nat. Synth. 2023, 2, 645-652. Chiral-at-Ru Catalyst with Cyclometalated Imidazo[1,5-a]pyridinylidene for Enantioselective Intramolecular Cyclopropanations: F. Han, Y. Xie, X. Xie, S. I. Ivlev, E. Meggers, Synlett 2023, 34, 1403-1408. Symmetry-breaking host-guest assembly in a hydrogen-bonded supramolecular system: S. Horiuchi, T. Yamaguchi, J. Tessarolo, H. Tanaka, E. Sakuda, Y. Arikawa, E. Meggers, G. H. Clever, K. Umakoshi, Nat. Commun. 2023, 14, 155. Improving the Configurational Stability of Chiral-at-Iron Catalysts Containing Two N(2-Pyridyl)-Substituted NHeterocyclic Carbene Ligands: N. Demirel, J. Haber, S. I. Ivlev, E. Meggers, Organometallics 2022, 24, 3852. See also Cover. Nitrene-Mediated C-H Oxygenation: Catalytic Enantioselective Formation of Five-Membered Cyclic Organic Carbonates: X. Nie, C.-X. Ye, S. I. Ivlev, E. Meggers, Angew. Chem. Int. Ed. 2022, 61, e202211971. Cyclometalated Chiral-at-Ruthenium Catalyst for Enantioselective Ring-Closing C(sp3)-H Carbene Insertion to Access Chiral Flavanones: F. Han, P. H. Choi, C.-X. Ye, Y. Grell, X. Xie, S. I. Ivlev, S. Chen, E. Meggers, ACS Catal. 2022, 12, 10304-10312. Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids: C.-X. Ye, X. Shen, S. Chen, E. Meggers, Nat. Chem. 2022, 14, 566-573. Electrochemical Enantioselective Nucleophilic C(sp3)-H Alkenylation of 2-Acyl Imidazoles: P. Xiong, M. Hemming, S. I. Ivlev, E. Meggers, J. Am. Chem. Soc. 2022, 144, 6964-6971. Deracemization of Chiral-at-Ruthenium Catalyst by Diastereoselective Dynamic Resolution: D. Baran, S. I. Ivlev, E. Meggers, Organometallics 2022, 41, 52-59. (ACS Editors' Choice). Catalytic Enantioselective Oxidative Homocoupling of 2-Acyl Imidazoles: N. Demirel, J. Qin. S. I. Ivlev, E. Meggers, Adv. Synth. Catal. 2021, 363, 4695-4700. Enantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by Non-C2-Symmetric Chiral-at-Rhodium Catalyst: Y. Grell, X. Xie, S. I. Ivlev, E. Meggers, ACS Catal. 2021, 11, 11396-11406. Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation: C. Zhang, A. Z. Gao, X. Nie, C.-X. Ye, S. I. Ivlev, S. Chen, E. Meggers, J. Am. Chem. Soc. 2021, 143, 13393-13400. Understanding the mechanism of direct visible-light-activated [2 + 2] cycloadditions mediated by Rh and Ir photocatalysts: combined computational and spectroscopic studies: H. Jung, M. Hong, M. Marchini, M. Villa, P. S. Steinlandt, X. Huang, M. Hemming, E. Meggers, P. Ceroni, J. Park, M.-H. Baik, Chem. Sci. 2021, 12, 9673-9681. Stereogenic-at-Iron Catalysts with a Chiral Tripodal Pentadentate Ligand: P. S. Steinlandt, X. Xie, S. Ivlev, E. Meggers, ACS Catal. 2021, 11, 7467-7476. Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction: Y. Hong, T. Cui, S. Ivlev, E. Meggers, Chem. Eur. J. 2021, 8557-8563. Chiral-at-Ruthenium Catalysts with Mixed Normal and Abnormal N-Heterocyclic Carbene Ligands: E. Winterling, S. Ivlev, E. Meggers, Organometallics 2021, 40, 1148-1155. Bis-Cyclometalated Indazole and Benzimidazole Chiral-at-Iridium Complexes. Synthesis and Asymmetric Catalysis: S. Brunen, Y. Grell, P. S. Steinlandt, K. Harms, E. Meggers, Molecules 2021, 26, 1822. Efficient Amination of Activated and Non-Activated C(sp3)-H Bonds with Simple Iron-Phenanthroline Catalyst: L. Jarrige, Z. Zhou, M. Hemming, E. Meggers, Angew. Chem. Int. Ed. 2021, 60, 6314-6319. Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion: Z. Zhou, Y. Tan, X. Shen, S. Ivlev, E. Meggers, Sci. China Chem. 2021, 64, 452-458. Ruthenium Pybox-Catalyzed Enantioselective Intramolecular C–H Amination of Sulfamoyl Azides en Route to Chiral Vicinal Diamines: X. Nie, Z. Yan, S. Ivlev, E. Meggers, J. Org. Chem. 2021, 86, 750-761. Intermolecular C(sp3)-H Bond Oxygenation by Transition-Metal Acylnitrenoids: Y. Tan, S. Chen, Z. Zhou, Y. Hong, S. Ivlev, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2020, 132, 21890-21894. Asymmetric Ring-Closing Aminooxygenation of Alkenes en Route to 2-Amino-1,3-Diols with Vicinal Stereocenters: Y. Tan, F. Han, M. Hemming, J. Wang, K. Harms, X. Xie, E. Meggers, Org. Lett. 2020, 22, 6653-6656. Asymmetric Catalysis with a Chiral-at-Osmium Complex. G. Wang, Z. Zhou, X. Shen, E. Meggers, Chem. Commun. 2020, 56, 7714-7717 ("HOT Article"). Enantioselective Ring-Closing C-H Amination of Urea Derivatives: Z. Zhou, Y. Tan, T. Yamahira, S. Ivlev, X. Xie, R. Riedel, M. Hemming, M. Kimura, E. Meggers, Chem 2020, 6, 2024-2034 (highlighted: N. P. van Leest, K. M. van Vliet, B. de Bruin, Chem 2020, 6, 1851-1853). Atroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis: C.-X. Ye, S. Shen, F. Han, X. Xie, S. Ivlev, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2020, 59, 13552-13556. Complementing Pyridine-2,6-bis(oxazoline) with Cyclometalated N-Heterocyclic Carbene for Asymmetric Ruthenium Catalysis: L. Li, F. Han, X. Nie, Y. Hong, S. Ivlev, E. Meggers, Angew. Chem. Int. Ed. 2020, 59, 12392-12395. Ruthenacarboran-Phenanthroline Derivatives as Potential Metallodrugs: M. Kellert, I. Sárosi, R. Rajaratnam, E. Meggers, P. Lönnecke, E. Hey-Hawkins, Molecules 2020, 25, 2322. Directed Evolution of an Fe(II)-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination: S. Duewel, L. Schmermund, T. Faber, K. Harms, V. Srinivasan, E. Meggers, S. Hoebenreich, ACS Catal. 2020, 10, 1272-1277. Non-C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)-H Amidation: Z. Zhou, S. Chen, Y. Hong, E. Winterling, Y. Tan, M. Hemming, K. Harms, K. N. Houk, E. Meggers, J. Am. Chem. Soc. 2019, 141, 19048-19057. Asymmetric Synthesis of 1,4-Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom Transfer Photocatalysis with Chiral Lewis Acid Catalysis: Y. Kuang, K. Wang, X. Shi, X. Huang, E. Meggers, J. Wu, Angew. Chem. Int. Ed. 2019, 58, 16859-16863. Bis-Cyclometalated Indazole Chiral-at-Rhodium Catalyst for Asymmetric Photoredox Cyanoalkylation: P. S. Steinlandt, W. Zuo, K. Harms, E. Meggers, Chem. Eur. J. 2019, 25, 15333-15340 ("Hot Paper"). Enantioconvergent Photoredox Radical−Radical Coupling Catalyzed by a Chiral-at-Rhodium Complex: Z. Zhou, X. Nie, K. Harms, R. Riedel, L. Zhang, E. Meggers, Sci. China Chem. 2019, 62, 1512-1518. Chiral-at-Rhodium Catalyst Containing Two Different Cyclometalating Ligands: Y. Grell, Y. Hong, X. Huang, T. Mochizuki, X. Xie, K. Harms, E. Meggers, Organometallics 2019, 38, 3948-3954. Chiral Bis(oxazoline) Ligands as C2-Symmetric Chiral Auxiliaries for the Synthesis of Enantiomerically Pure Bis-Cyclometalated Rhodium(III) Complexes: Y. Grell, N. Demirel, K. Harms, E. Meggers, Organometallics 2019, 38, 3852-3859. Asymmetric Photocatalysis by Intramolecular Hydrogen-Atom Transfer in Photoexcited Catalyst–Substrate Complex: C. Zhang, S. Chen, C.-X. Ye, K. Harms, L. Zhang, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2019, 58, 14462-14466. Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis: Y. Hong, L. Jarrige, K. Harms, E. Meggers, J. Am. Chem. Soc. 2019, 141, 4569-4572. Enantioselective intramolecular C-H amination of aliphatic azides by dual ruthenium and phosphine catalysis: J. Qin, Z. Zhou, T. Cui, M. Hemming, E. Meggers, Chem. Sci. 2019, 10, 3202-3207. Electricity-driven asymmetric Lewis acid catalysis: X. Huang, Q. Zhang, J. Lin, K. Harms, E. Meggers, Nat. Catal. 2019, 2, 34-40. Catalytic enantioselective intramolecular C(sp3)-H amination of 2-azidoacetamides: Z. Zhou, S. Chen, J. Qin, X. Nie, X. Zheng, K. Harms, R. Riedel, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2019, 58, 1088-1093. Kinetic resolution of epoxides with CO2 catalyzed by a chiral-at-iridium complex: J. Qin, V. A. Larionov, K. Harms, E. Meggers, ChemSusChem 2019, 12, 320-325. Chiral-at-ruthenium catalyst with sterically demanding furo[3,2-b]pyridine ligands: T. Cui, J. Qin, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2019, 195-198