Zariwala, Mohammed Gulrez - University of Westminster - Department of Biomedical Sciences

个人简介

I am currently a Lecturer in Physiology at the University of Westminster. Prior to this I was a Lecturer in Cell & Molecular Biology at the University of Bedfordshire. I am a graduate in pharmaceutical sciences from the University of Mumbai, India. I began my academic studies in the UK with an MSc in Drug Delivery at the UCL School of Pharmacy, graduating with a distinction. My PhD studies (Diabetes and Metabolic Medicine) were conducted under a Diabetes UK studentship award at the Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London. I have broad interests in academic research as well as research enterprise and commercialisation. General areas of interest are: Appetite regulation and satiety - role of specific dietary components and the underlying mechanism Mechanisms of Type 2 diabetes at the beta-cell level Nanotechnology based targeted drug/nutraceutical formulation and delivery Applicants who are interested in PhD (self-funded) or shorter undergraduate and postgraduate level research projects in the above fields are welcome to get in touch.

研究领域

I have broad interests in academic research as well as research enterprise. My areas of focus are: Appetite regulation/obesity Mechanisms of Type 2 diabetes Nanotechnology based targeted drug/nutraceutical formulation and delivery Current projects include research in the role of iron mediated oxidative stress on pancreatic cell insulin secretory dysfunction in Type 2 diabetes. I have previously investigated the effects of specific dietary nutrients on the release and secretion of the appetite regulating peptide YY using a human gut cell model - Caco-2 transwell system (Society for endocrinology Early Career Grant). Continued research investigations in this area may provide interesting insights in the dynamics of satiety, appetite regulation and obesity. My past research commercialisation projects include a Knowledge Transfer Partnership (KTP) project that resulted in the development of a novel iron supplement product currently being marketed worldwide, and a Project for Accessible Research Knowledge (PARK) project where I developed an innovative nanotechnology based 'Micronutrient Delivery Platform' for targeted delivery of mineral nutrients to the gut to achieve high absorption. I am also involved in the design and formulation of biodegradable nano sized carriers for site specific and controlled delivery of drugs, bioactive peptides, micronutrients and phytochemicals. I use a nanotechnology based approach in combination with the Caco-2 cell absorption screening model that has wide applications in the pharmaceutical and nutraceutical fields.

近期论文

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Zupančič S, Zariwala MG, Renshaw D, Kocbek P, Somavarapu S. Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation. Molecular Pharmaceutics. 2014 Jul ;11 (7):2334-45. Zariwala MG, Farnaud S, Merchant Z, Somavarapu S, Renshaw D. Ascorbyl Palmitate/DSPE-PEG nanocarriers for oral iron delivery: preparation, characterization and in vitro evaluation. Colloids and Surfaces: B. 2014 March. (115): 86-92. Zariwala MG, Farnaud S, Elsaid N, Somavarapu S, Renshaw D. A Novel approach to oral iron delivery using ferrous sulphate solid lipid particles. International Journal of Pharmaceutics. 2013 November; 456(2):400-7 Zariwala MG, Somavarapu S, Farnaud S, Renshaw D. Comparison study of iron preparations using a human intestinal model. Scientia Pharmaceutica. 2013 December; 81(4):1123 - 1139 Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ, Renshaw D (2013). Attenuation of plasma annexin A1 in human obesity. FASEB J. January 2013. 27(1):368-78 Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M, Renshaw D (2013). Annexin-A1 protein and its relationship to cortisol in human saliva. Psychoneuroendocrinology. 2013 May; 38 (5):722-7. Epub 2012 Sep 25 Holness MJ, Zariwala MG, Walker CG, Sugden MC. Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity. Febs Open Bio. 2012 March; 5;2:32-6 Sugden MC, Zariwala MG, Holness MJ. PPARs and the orchestration of metabolic fuel selection. Pharmacol Res. 2009 Sep; 60(3):141-50. Pandit S, Cevher E, Zariwala MG, Somavarapu S, Alpar HO. Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against hepatitis B through incorporation of alum and chitosan. J Microencapsul. 2007 Sep; 24(6):539-52.