Lange, Sigrun - University of Westminster - Department of Biomedical Sciences

个人简介

Formal Education: BSc Biology; MSc Biomedical Sciences; PhD Biomedical Sciences After obtaining a BSc in Biology from the University of Iceland in 1999, I undertook a MSc research project in Biomedical Sciences studying the teleost immune system at the Institute for Experimental Pathology, University of Iceland in collaboration with UiT The Arctic University of Tromsø, Norway, supported by an EMBO fellowship. My PhD (2001-2005) formed part of the EU FISHAID project and was the first ontogeny study on the complement system in an early vertebrate species, supporting my hypothesis on diverse roles of the complement system in organogenesis and the immune defence. For this work I received the Prof. Axelsson´s Young Investigators Award in 2005. I obtained visiting fellowships from the EMBO and IUBMB to collaborate with the MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford (2002; with Prof KBM Reid, FRS and Dr AW Dodds) and the Department of Biomedicine, University Hospital Basel, Switzerland (2003-2005; with Profs JA Schifferli & JM Inal). Having developed a special interest in the immune system in the context of regeneration and neuroimmunology, I spent 8 post-doctoral years at UCL in developmental, molecular and cellular neuroscience research. I carried out proteomic and genomic screening to identify candidate molecules underlying spinal cord regeneration at the UCL Institute of Child Health (2006-2010); studied neuroinflammatory responses and post-translational modifications in perinatal brain repair at the UCL Institute for Women’s Health (2010-2013); and participated in the brain-simulation part of the EU Flagship Human Brain Project, creating 3D-reconstructions of interneurones of the hippocampus for in silico modelling at the UCL School of Pharmacy (2013-2015). During my post-doctoral research I identified novel molecules underlying acute central nervous system damage, regeneration and neuroinflammation. I showed novel and translatable pharmacological treatment options, developing an independent strand of research focussing on peptidylarginine deiminases (PADs) and pharmacological inhibition, in animal models of spinal cord injury and neonatal hypoxic ischaemic insult in vivo. I also worked on projects identifying novel regulatory mechanisms in neuronal progenitor cells and conducted pilot-studies on putative roles of PAD-enzymes in neurodegenerative iPSC models. Since 2010 I have ongoing collaborative projects on microvesicles in health and disease, recently describing novel roles of the complement system and the PAD enzymes and putative therapies for prostate cancer. In 2015 I received the Young Scientist Award from the Icelandic Biological Society. I joined the Department of Biomedical Sciences as lecturer in Molecular Pathology in January 2016.

研究领域

My research interest are inflammation, neuroimmunology and microvesicles and how posttranslational protein modifications modulate inflammatory and epigenetic responses.

近期论文

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Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal J, Lange S (2015). A Novel Role for Peptidylarginine Deiminases (PADs) in Microvesicle Release: A Therapeutic Potential for PAD Inhibitors to Sensitize Prostate Cancer Cells to Chemotherapy. Journal of Extracellular Vesicles Jun 19;4:26192. doi: 10.3402/jev.v4.26192. Jorfi S, Ansa-Addo E, Kholia S, Stratton D, Valley S, Lange S, Inal J. (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific Reports 5:13006. doi: 10.1038/srep13006. Stratton D, Moore C, Antwi-Baffour S, Lange S, Inal J (2015). Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2015.03.074. Stratton D, Moore C, Zheng L, Lange S, Inal J (2015). Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2015.03.061. Lange S, Rocha Ferreira E, Thei L, Mawjee P, Thompson PR, Nicholas AP, Hristova M, Peebles D, Raivich G (2014). Peptidylarginine Deiminases (PADs) – Novel Drug Targets for Prevention of Neuronal Damage following Hypoxic Ischaemic Insult (HI) in Neonates. J Neurochem 130(4):555-62. Stratton D, Lange S, Kholia S, Jorfi S, Antwi-Baffour S, Inal J (2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2014.09.132. Stratton D, Lange S, Inal JM (2013). Pulsed extremely low-frequency magnetic fields stimulate microvesiclerelease from human monocytic leukaemia cells. Biochem Biophys Res Commun. 11;430(2):470-5. Lange, S, Gogel, S, Leung, K-Y, Nicolas, PA, Causey, CP, Thompson, PR, Greene, ND, Ferretti, P (2011). Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biology, 15; 355(2):205-14. Grant R, Ansa-Addo E, Stratton D, Antwi-Baffour S, Jorfi S, Kholia S, Krige L, Lange S, Inal J (2011). A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma.J Immunol Methods. 371(1-2):143-51.