Elliott, Bradley - University of Westminster - Department of Biomedical Sciences

个人简介

I studied for a Bachelor of Science (Honours) in the Department of Sport and Exercise Sciences at the University of Auckland, New Zealand before completing a Master of Science (Experimental Medicine) at Université Laval, Canada. My doctorate was done here at the University of Westminster where I worked on human and applied physiology, examining myostatin regulation during acute hypoxic insult in healthy humans, as a model of chronic disorders. During the course of my doctorate I have also had the chance to complete a Post Graduate Certificate in Teaching & Learning, and am a Fellow of the Higher Education Academy. I teach physiology across undergraduate and graduate programmes, as well as maintaining an active research programme into muscle atrophy, frailty and aging. I also lead the Translational Physiology Research Group, who's remit is translation of in vitro into the human in vivo to better understand human function. I also engage in wider scientific communication where possible, appearing on documentaries for the BBC, Channel 4 and in print media. In 2016 I provided technical assistance in the production of the Royal Institution's Christmas Lecture

研究领域

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My research can be described as translational physiology and examines the effect of atrophic stimuli upon muscle size both in vitro and in vivo, with particular focus on the regulation of cell size and the role of myostatin signalling in this process. In vitro, I use the C2C12 mouse myoblast line, perturbed with atrophic or hypertrophic stimuli, before examining changes in cell size by microscopy and alterations in cellular signalling pathways by Western blot. In vivo healthy humans are exposed to stimuli such as disuse, hypoxia or resistance training, with blood and muscle tissue collected for analysis. By understanding the basic science of how muscle is gained and lost when homeostasis is challenged, I hope to uncover the mechanism underlying atrophy of muscle during disease and aging, and ultimately prevent them. I also have a secondary reserach focus on the itergration of modern digital tools (tablets, wearables and smartphones) into physiology teaching and research.