Camilleri, Ray - University of Westminster - Department of Biomedical Sciences

个人简介

I graduated with a BSc Honours degree in Medical Biochemistry from Royal Holloway, University of London in 1994 before embarking on a PhD CASE studentship in Molecular Biology and Biochemistry at Royal Holloway and Zeneca Agrochemicals, under the supervision of Prof. John Bowyer. After gaining my PhD ("Molecular genetic and biochemical studies of the D1-processing protease of Arabidopsis thaliana") in 1998, I spent a further year at Zeneca Agrochemicals developing new cell- and enzyme-based high-throughput screening assays for a number of neurotransmitter receptors and potential fungicide targets. I moved back to London at the start of the millennium to take up a Postdoctoral Research Fellow position in the Haemostasis Research Unit, Department of Haematology at University College London with Prof. Samuel Machin, Dr Ian Mackie and Dr Hannah Cohen. I began by investigating the molecular biological aspects of 2-glycoprotein I (2GPI) in antiphospholipid syndrome, and fibrinogen and its association with the thrombophilic markers Factor V Leiden, prothrombin gene mutation G20210A and MTHFR C677T in venous thrombosis, stroke, recurrent miscarriage and pregnancy complications. Most recently, my research has been focused on von Willebrand factor-cleaving protease (ADAMTS13) and thrombotic thrombocytopenic purpura (TTP), where I have also been working with Dr Marie Scully at University College London Hospitals NHS Foundation Trust in trying to elucidate a link between ADAMTS13 genotype and patient phenotype. I joined the academic staff at the University of Westminster (UoW) as a Senior Lecturer in Biomedical Sciences in January 2011. I teach both undergraduate and postgraduate students in modules ranging from haematology and transfusion science, cell science, human anatomy and physiology, biochemistry and molecular biology, biology of disease, principles of laboratory diagnosis, processes in pathology and haemostasis. I also supervise undergraduate (BSc) and postgraduate (MSc) research projects and am currently supervising a PhD student looking at various genetic and in vitro functional aspects of ADAMTS13 and other thrombotic markers related to the development of TTP. I am also Deputy Course Leader for full-time BSc Biomedical Sciences and Admissions Tutor for BSc Biomedical Sciences.

研究领域

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My research interests broadly cover the molecular biological and biochemical aspects of various thrombotic and haemostatic disorders. This has included work on the genotype of the glycoprotein 2GPI and its relationship with antiphospholipid syndrome. It has also included studies on fibrinogen and its association with Factor V Leiden, prothrombin gene mutation G20210A and MTHFR C677T in patients suffering from pulmonary embolism, deep vein thrombosis, cerebral vascular attack, foetal loss and severe obstetric complications. I am now undertaking research on the molecular biological and functional aspects of von Willebrand factor-cleaving protease (ADAMTS13) and its correlation with thrombotic thrombocytopenic purpura (TTP), a disorder characterised by widespread microvascular platelet-rich thrombi, which result in profound thrombocytopenia and microangiopathic haemolytic anaemia. To date, I have identified 17 (11 novel) functional ADAMTS13 mutations and a number of single nucleotide polymorphisms (SNPs) in a variety of TTP patient phenotypes, including some individuals who first presented with TTP in adulthood.