Getting, Stephen - University of Westminster - Department of Life Sciences

个人简介

I graduated from the School of Pharmacy, London in 1995 with a BSc (Hons) Toxicology and Pharmacology; this Sandwich degree encompassed a year's industrial experience at the Wellcome Research laboratories, Beckenham, Kent under the guidance of Dr Mike Yeadon. Following graduation I undertook a research assistant and part-time PhD position looking at the role of annexin 1 and melanocortin peptides in experimental inflammation at the William Harvey Research Institute, Bart's and the London Medical Schools (supervisors Professor Mauro Perretti and Professor Rod Flower, FRS) which encompassed a period of training at Monash Medical School, Melbourne, Australia in the laboratory of Professor Eric Morand. During my PhD, I identified the melanocortin type 3 receptor, as a novel target for modulating the host inflammatory response and was awarded the C. Gordon Van Arman award for Excellence in Inflammation Research from the Inflammation Research Association in 1998. Following my PhD, I undertook a post-doctoral position (2000-2005) at the William Harvey Research Institute unravelling the anti-inflammatory effects of the melanocortin peptides in models of arthritis, and respiratory disease. During this time I was awarded a fellowship at the Second University of Naples, under the guidance of Professor Michele D'Amico evaluating the role of the melanocortin type 3 receptor, in cardiovascular disease and was awarded the Derek Willoughby Young Investigator Award at the 5th World Congress on Inflammation in 2001. In 2006 I joined the Thoracic medicine group at the National Heart and Lung Institute, Imperial College, London as a senior postdoctoral scientist with Professors Ian Adcock and Kaz Ito evaluating the role of HDAC2 in COPD. Following this position I took up a senior lectureship in Pharmacology at the University of Westminster in the Department of Human and Health Sciences, School of Life Sciences and was awarded a post graduate certificate in higher education in 2009 and fellowship of the Higher Education Academy in 2010. Since 2010 I have been research co-ordinator for the Cell Communication Research Cluster across the Faculty of Science and Technology with the remit of fostering links across other research platforms and involving undergraduate, postgraduate and doctoral scientists within the development of the cluster. I am also a member of the Faculty Research Committee and student affairs coordinator for the Department of Life Sciences. To date I have published over 50 (papers, reviews), 2 book chapters and over 80 abstracts) including papers in Nature Medicine, J. Ex. Med, British Journal of Pharmacology, Journal of Immunology, Arthritis and Rheumatism, TIPS and FASEB J. I have also supervised 7 students to PhD completion.

研究领域

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I am a pharmacologist interested in unravelling the biological effects of endogenous modulators of the host inflammatory response. My main interest is understanding the role played by the melanocortin peptides. The aim of this research is to understand their mechanism of action of these peptides and identification of the target receptors for pharmacological manipulation and subsequent disease treatment. Understanding how these naturally occurring anti-inflammatory agents exhibit a dual mechanism of action i.e. an early phase inhibition of cytokine release and a late induction of pro-resolving pathways is an exciting development. This research will hopefully lead to development of novel therapeutics to treat some of the biggest debilitating diseases that we face including arthritis and cerebral ischaemia. At present my main research areas involve looking at the biological effects of these peptides in human osteoarthritic cell-lines and in models of neuroinflammation and neuroprotection.