Jones, Alex - University of Warwick - Department of Biotechnology

个人简介

Reader, School of Life Sciences, University of Warwick. 2013-present Head of Proteomics at The Sainsbury Laboratory, Norwich, 2005-2013 Post-doctoral researcher Targeting of EDS1/PAD4 resistance signalling complexes by bacterial effector proteins Imperial College, London. 2004-2005 Post-doctoral researcher "Comparative analysis of the defence proteome of Arabidopsis thaliana" Imperial College Wye Campus 2001-2004 Post-doctoral researcher "The impact of transgenes for herbivore and virus resistance on the weediness of crop relatives" at the Centre for Ecology and Hydrology, Dorset. 1999-2001 PhD "Purification and Sequencing of Myrosinase from the Cabbage Aphid". Imperial College Wye campus 1999 MSc Applied Plant Sciences. Imperial College Wye campus 1995 BSc (Hons) Chemistry & Biochemistry. Imperial College London 1990-1993

研究领域

To flourish plants need to adapt their growth and development in response to changes in their environment. Great progress has been made in determining the mechanisms of signal perception and an essential part of subsequent responses is rapid alteration of cellular membranes and the cell wall. Beyond transport of materials, the internalization and secretion of plasma membrane receptors can regulate signal duration and create local signal gradients. Thus, the trafficking of vesicles within a cell can be viewed as regulating overall cellular output. The mechanisms of how signal pathways and membrane trafficking events interact are largely unknown, but substantial rearrangements occur quickly, likely using pre-formed proteins. The question my research seeks to address is 'how are the mechanisms of membrane trafficking involved in normal growth and development, adapted for responses to biotic and abiotic stress?' My objective is to identify components recruited to responsive trafficking mechanisms and provide targets to uncouple negative impacts on plant growth during adaptation to stress. My group uses the model plant Arabidopsis thaliana, advanced proteomics, confocal microscopy and biochemistry to identify protein complexes and post-translational modifications at the interface between signal perception and responsive trafficking.

近期论文

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Wirthmueller, Lennart, Roth, Charlotte, Fabro, Georgina, Caillaud, Marie-Cécile, Rallapalli, Ghanasyam, Asai, Shuta, Sklenar, Jan, Jones, Alexandra M., Wiermer, Marcel, Jones, Jonathan D. G., Banfield, Mark J.. 2015. Probing formation of cargo/importin-a transport complexes in plant cells using a pathogen effector. The Plant Journal, Volume 81 (Number 1), pp. 40-52, View Heard, William, Sklenar, Jan, Tomé, Daniel F. A., Robatzek, Silke, Jones, Alexandra M.. 2015. Identification of regulatory and cargo proteins of endosomal and secretory pathways in Arabidopsis thaliana by proteomic dissection. Molecular & Cellular Proteomics, 14, pp. 1796-1813, View Chaparro-Garcia, Angela, Schwizer, Simon, Sklenar, Jan, Yoshida, Kentaro, Petre, Benjamin, Bos, Jorunn I. B., Schornack, Sebastian, Jones, Alexandra M., Bozkurt, Tolga O., Kamoun, Sophien. 2015. Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2. PLoS One, 10 (9), View Christie-Oleza, Joseph Alexander, Sousoni, Despoina, Armengaud, Jean, Wellington, E. M. H., Jones, Alexandra M.. 2015. Defining a pipeline for metaproteomic analyses. Springer Protocols Handbooks, View Shao, Nan, Singh, N. Sadanands, Slade, Susan E., Jones, Alexandra M., Balasubramanian, Mohan K.. 2015. Site specific genetic incorporation of azidophenylalanine in Schizosaccharomyces pombe. Scientific Reports, 5, pp. 1-9, View Liebrand, Thomas W.H., Kombrink, Anja, Zhang, Zhao, Sklenar, Jan, Jones, Alexandra M., Robatzek, Silke, Thomma, Bart P.H.J., Joosten, Matthieu H.A.J.. 2014. Chaperones of the endoplasmic reticulum are required for Ve1-mediated resistance to Verticillium. Molecular Plant Pathology, Volume 15 (Number 1), pp. 109-117, View Wilhelm, Thomas, Jones, Alexandra M.. 2014. Identification of related peptides through the analysis of fragment ion mass shifts. Journal of Proteome Research, Volume 13 (Number 9), pp. 4002-4011, View Piquerez, Sophie J., Balmuth, Alexi L., Sklenà¡r, Jan, Jones, Alexandra M., Rathjen, John P., Ntoukakis, Vardis. 2014. Identification of post-translational modifications of plant protein complexes. Journal of Visualized Experiments (Number 84), View