Holub, Eric - University of Warwick - Department of Biotechnology

研究领域

Professor Holub trained in legume pathology and plant breeding in the US, completing research that catalysed a public-commercial partnership with regional seed companies for release of multiple disease resistance in alfalfa forage varieties. His genetics career began in the UK as a postdoc with Professor Ian Crute. They established experimental models in Arabidopsis thaliana for molecular investigation of resistance to two highly specialised pathogens (Hyaloperonospora arabidopsidis and Albugo laibachii). This work led to numerous publications on R-gene mediated resistance, defense-signaling and pathogen avirulence with UK and international collaborators. His transition back to bonafide crop pathogens, began with genetic dissection of non-host resistance in A. thaliana to Albugo candida (brassica white blister rust). This has led to molecular characterisation of a broad-spectrum receptor-like resistance gene WRR4, that has potential use in transgenic brassica crops. A high quality reference genome for A. candida race 2V has also been generated from further collaboration with Canadian partners. His interests in tackling challenges of food insecurity includes research to improve disease resistance in brassicas (downy mildew, white blister rust and black rot), drawing of advances from A. thaliana research. He has also recently revived elite material from the NVRS-Wellesbourne Phaseolus baked bean breeding programme, which had been working to adapt this crop for UK production.

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Buckley, James, Kilbride, Elizabeth, Cevik, Volkan, Vicente, Joana G., Holub, E. B., Mable, Barbara K.. 2016. R-gene variation across Arabidopsis lyrata subspecies : effects of population structure, selection and mating system. BMC Evolutionary Biology, 16 (1), View Baroncelli, Riccardo, Amby, Daniel Buchvaldt, Zapparata, Antonio, Sarrocco, Sabrina, Vannacci, Giovanni, Le Floch, Gaétan, Harrison, Richard J., Holub, E. B., Sukno, Serenella A., Sreenivasaprasad, Surapareddy, Thon, Michael R.. 2016. Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum. BMC Genomics, 17 (1), View Xu, Fang, Zhu, Chipan, Cevik, Volkan, Johnson, Kaeli, Liu, Yanan, Sohn, Kee-Hoon, Jones, Jonathan D. G., Holub, E. B., Li, Xin. 2015. Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TIR-NB-LRR encoding neighbour. Scientific Reports, Volume 5, pp. 1-7, View McMullan, Mark, Gardiner, Anastasia, Bailey, Kate, Kemen, Eric, Ward, Ben J., Cevik, Volkan, Robert-Seilaniantz, Alexandre, Schultz-Larsen, Torsten, Balmuth, Alexi L., Holub, E. B., Oosterhout, Cock van, Jones, Jonathan D. G.. 2015. Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. eLife, Volume 4, pp. 1-24, View Baroncelli, Riccardo, Zapparata, Antonio, Sarrocco, Sabrina, Sukno, Serenella A., Lane, Charles R., Thon, Michael R., Vannacci, Giovanni, Holub, E. B., Sreenivasaprasad, S.. 2015. Molecular diversity of anthracnose pathogen populations associated with UK strawberry production suggests multiple introductions of three different colletotrichum species. PLoS One, Volume 10 (Number 6), pp. 1-21, View Baroncelli, Riccardo, Sreenivasaprasad, S., Sukno, S. A., Thon, M. R., Holub, E. B.. 2014. Draft genome sequence of Colletotrichum acutatum sensu lato (Colletotrichum fioriniae). Genome Announcements, Volume 2 (Number 2), pp. e00112-e00114, View Vicente, Joana G., Holub, E. B.. 2013. Xanthomonas campestris pv. campestris (cause of black rot of crucifers) in the genomic era is still a worldwide threat to brassica crops. Molecular Plant Pathology, Vol.14 (No.1), pp. 2-18, View Vicente, Joana G., Gunn, Nick, Bailey, Liz, Pink, David, Holub, E. B.. 2012. Genetics of resistance to downy mildew in Brassica oleracea and breeding towards durable disease control for UK vegetable production. Plant Pathology, Vol.61 (No.3), pp. 600-609, View Mulema, Joseph M. K., Vicente, Joana G., Pink, David, Jackson, Alison C., Chacha, Duncan O., Wasilwa, L. A. (Lusike A.), Kinyua, Zakary M., Karanja, Daniel K., Holub, E. B., Hand, Paul. 2012. Characterization of isolates that cause black rot of crucifers in East Africa. European Journal of Plant Pathology, Vol.133 (No.2), pp. 427-438, View