Gifford, Miriam - University of Warwick - Department of Biotechnology

个人简介

Associate Professor, Systems biology of nitrogen-regulated development, School of Life Sciences, University of Warwick, July 2014 to present. Assistant Professor, Systems biology of nitrogen-regulated development, School of Life Sciences, University of Warwick, 2009 to June 2014. EMBO post-doctoral fellow, Integrating nitrogen-regulatory networks and development, New York University 2004-2008. PhD, Cell layer specification during Arabidopsis embryogenesis, University of Edinburgh, 2004, BSc Hons, Plant Science, University of Edinburgh 2001, Membership of societies: The Society for Experimental Biology, The American Society of Plant Biologists, The Society for Developmental Biology, The Genetics Society, UK

研究领域

We are interested in how an organism interacts with its environment. The mechanisms that facilitate this interaction are particularly important for plants since they are sessile yet still cope with environmental extremes. Our work investigates the evolution of cell types in determining plant plasticity. This includes using systems analysis to understand the nitrogen-fixing symbiosis of nodulation, with the long-term aim of transferring it from legumes to staple crop species. We use Fluorescence-Activated Cell Sorting (FACS) in combination with genomics and gene network inference to analyse the specific root cell types involved in symbiosis and environmental responses. We will use this information to identify how synthetic biology could be used to rewire plant responses to develop crops that can adapt to a changing climate.

近期论文

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Ferrà¡ndez-Ayela, Almudena, Sà¡nchez-Garcàa, Ana Belén, Martinez-Andejar, Cristina, Kevei, Zoltan, Gifford, Miriam L., Thompson, Andrew J., Pérez-Alfocea, Francisco, Pérez-Pérez, José Manuel. 2016. Identification of novel stress-responsive biomarkers from gene expression datasets in tomato roots. Functional Plant Biology, 43 (8), pp. 783-796, View Ferrà¡ndez-Ayela, Almudena, Sà¡nchez-Garcàa, Ana Belén, Martànez-Andàºjar, Cristina, Gifford, Miriam L., Thompson, Andrew J., Pérez-Alfocea, Francisco, Pérez-Pérez, José Manuel. 2016. Identification of novel stress-responsive biomarkers from gene expression datasets in tomato roots. Functional Plant Biology, 43 (8), pp. 783-796, View Coker, Timothy L. R., Cevik, Volkan, Beynon, Jim, Gifford, Miriam L.. 2015. Spatial dissection of the Arabidopsis thaliana transcriptional response to downy mildew using fluorescence activated cell sorting. Frontiers in plant science, Volume 6, pp. 1-13, View Vernié, Tatiana, Kim, Jiyoung, Frances, Lisa, Ding, Yiliang, Sun, Jongho, Guan, Dian, Niebel, Andreas, Gifford, Miriam L., de Carvalho-Niebel, Fernanda, Oldroyd, Giles E. D.. 2015. The NIN transcription factor coordinates diverse nodulation programmes in different tissues of the root. The Plant Cell, 27 (12), pp. 3410-3424, View Reitz, M. U., Gifford, Miriam L., Schäfer, Patrick. 2015. Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition. Journal of Experimental Botany, 66 (8), pp. 2187-2197, View Lagunas, B., Schäfer, Patrick, Gifford, Miriam L.. 2015. Housing helpful invaders : the evolutionary and molecular architecture underlying plant root-mutualist microbe interactions. Journal of Experimental Botany, 66 (8), pp. 2177-2186, View Wang, Ying, Penfold, Christopher A., Hodgson, D. A. (David A.), Gifford, Miriam L., Burroughs, Nigel John. 2014. Correcting for link loss in causal network inference caused by regulator interference. Bioinformatics, Volume 30 (Number 19), pp. 2779-2786, View Rosas, Ulises, Cibrian-Jaramillo, Angelica, Ristova, Daniela, Banta, Joshua A., Gifford, Miriam L., Fan, A. H., Zhou, R. W., Kim, G. J., Krouk, G., Birnbaum, Kenneth D., Purugganan, Michael D., Coruzzi, G. M.. 2013. Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture. Proceedings of the National Academy of Sciences of the United States of America, Volume 110 (Number 37), pp. 15133-15138, View