Huckstepp, Robert - University of Warwick - Department of Biomedical Science

个人简介

PhD in Biology from Warwick University BSc (hons) in Biomedical Sciences from Durham University Member of the Society for Neuroscience Member of the Physiological Society Member of the European Society of Cardiology

研究领域

Cardiorespiratory control is essential for life from before birth all the way through, except for the briefest of pauses, to death. The neural networks that control cardiorespiratory activity form a dynamic microcircuit that must continually monitor and adapt to a set of ever-changing vital parameters (such as blood gas and pH levels) to maintain homeostasis. This cardiorespiratory microcircuit therefore has many components, and is subject to numerous internal, external and sensory control mechanisms. My research primarily focuses on the role of neurones and glia in the control of breathing, and how different groups of neurones within the respiratory network interact with one another to generate and pattern respiratory output. I am currently developing a model of sleep apnoea, to study the link between sleep disordered breathing and heart failure.

近期论文

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Huckstepp, Robert T. R., Henderson, Lauren E., Cardoza, Kathryn P., Feldman, Jack L.. 2016. Interactions between respiratory oscillators in adult rats. eLife, 5, View Huckstepp, Robert T. R., Llaudet, Enrique, Gourine, Alexander V.. 2016. CO2-induced ATP-dependent release of acetylcholine on the ventral surface of the medulla oblongata. PLoS One, 11 (12), View Huckstepp, Robert T. R., Cardoza, K. P., Henderson, L. E., Feldman, J. L.. 2015. Role of parafacial Nuclei in control of breathing in adult rats. Journal of Neuroscience, 35 (3), pp. 1052-1067, View Wells, J. A., Christie, I. N., Hosford, P. S., Huckstepp, Robert T. R., Angelova, P. R., Vihko, P., Cork, S. C., Abramov, A. Y., Teschemacher, A. G., Kasparov, S., Lythgoe, M. F., Gourine, A. V.. 2015. A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses. Journal of Neuroscience, 35 (13), pp. 5284-5292, View Shigetomi, E., Jackson-Weaver, O., Huckstepp, Robert T. R., O'Dell, T. J., Khakh, B. S.. 2013. TRPA1 Channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-Serine release. Journal of Neuroscience, 33 (24), pp. 10143-10153, View Huckstepp, Robert T. R., Dale, Nicholas. 2011. CO2-dependent opening of an inwardly rectifying K+ channel. Pfluegers Archiv, Vol.461 (No.3), pp. 337-344, View Huckstepp, Robert T. R., Bihi, Rachid Id, Eason, Robert, Spyer, K. Michael, Dicke, Nikolai, Willecke, Klaus, Marina, Nephtali, Gourine, Alexander V., Dale, Nicholas. 2010. Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. Journal of Physiology, Vol.588 (No.20), pp. 3901-3920, View Huckstepp, Robert T. R., Eason, Robert, Sachdev, Anshu, Dale, Nicholas. 2010. CO2-dependent opening of connexin 26 and related beta connexins. Journal of Physiology, Vol.588 (No.20), pp. 3921-3931, View Tian, Faming, Gourine, Alexander V., Huckstepp, Robert T. R., Dale, Nicholas. 2009. A microelectrode biosensor for real time monitoring of L-glutamate release. Analytica Chimica Acta, Vol.645 (No.1-2), pp. 86-91, View Gourine, Alexander V., Dale, Nicholas, Korsak, Alla, Llaudet, Enrique, Tian, Faming, Huckstepp, Robert T. R., Spyer, K. Michael. 2008. Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway. The Journal of Physiology, 586 (16), pp. 3963-3978, View