Frenguelli, Bruno - University of Warwick - Department of Biomedical Science

个人简介

PhD Pharmacology 1993. University of Birmingham

研究领域

The capacity of the human brain to learn and remember is enormous and has intrigued scientists,clinicians and philosophers for centuries. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of learning and memory, and how these processes may become disordered in disease states such as Alzheimer's Disease or after conditions such as Stroke. Our laboratory is interested in several aspects of the brain: its ability to learn and remember, its vulnerability to stroke, epilepsy and injury and the role that the purines ATP and adenosine, play in these processes.

近期论文

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Collingridge, Graham L., Lodge, David, Mayer, Mark, Turrigiano, Gina, Frenguelli, Bruno G.. 2017. Ionotropic glutamate receptors : still exciting after all these years. Neuropharmacology, 112, pp. 1-3, View Daumas, Stephanie, Hunter, Christopher J., Mistry, Rajen B., More, Lorenzo, Privitera, Lucia, Cooper, Daniel D., Reyskens, Kathleen M., Flynn, Harry T., Morris, Richard G. M., Simon, J., Arthur, C., Frenguelli, Bruno G.. 2017. The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro, View Knight, Anthony, Hemmings, Jennifer L., Winfield, Ian, Leuenberger, Michele, Frattini, Eugenia, Frenguelli, Bruno G., Dowell, Simon J., Lochner, Martin, Ladds, Graham. 2016. Discovery of novel adenosine receptor agonists that exhibit subtype selectivity. Journal of Medicinal Chemistry, 59 (3), pp. 947-964, View Frenguelli, Bruno G., Wall, Mark J.. 2016. Combined electrophysiological and biosensor approaches to study purinergic regulation of epileptiform activity in cortical tissue. Journal of Neuroscience Methods, 260, pp. 202-214, View Perry, David, Paulose Nadappuram, Binoy, Momotenko, Dmitry, Voyias, Philip D., Page, Ashley, Tripathi, G. N., Frenguelli, Bruno G., Unwin, Patrick R.. 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society, 138 (9), pp. 3152-3160, View Page, Ashley, Perry, David, Young, Philip J., Mitchell, Daniel Anthony, Frenguelli, Bruno G., Unwin, Patrick R.. 2016. Fast nanoscale surface charge mapping with pulsed-potential scanning ion conductance microscopy. Analytical Chemistry, 88 (22), pp. 10854-10859, View Page, Ashley, Perry, David, Young, Philip J., Mitchell, Daniel Anthony, Frenguelli, Bruno G., Unwin, Patrick R.. 2016. Fast nanoscale surface charge mapping with pulsed-potential scanning ion conductance microscopy. Analytical Chemistry, 88 (22), pp. 10854-10859, View Lopatà¡r, Jà¡n, Dale, Nicholas, Frenguelli, Bruno G.. 2015. Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations. Neuropharmacology, Volume 93, pp. 219-228, View Diogenes, M. J., Neves-Tome, R., Fucile, S., Martinello, K., Scianni, M., Theofilas, P., Lopatà¡r, Jà¡n, Ribeiro, J. A., Maggi, L., Frenguelli, Bruno G., Limatola, C., Boison, D., Sebastiao, A. M.. 2014. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cerebral Cortex, Volume 24 (Number 1), pp. 67-80, View