Wellington, Elizabeth - University of Warwick - Department of Biomedical Science

个人简介

Professor Liz Wellington is an active member of the Environment theme within the School of Life Sciences at the University of Warwick. She holds a personal chair and, with her research group, is involved in the study of bacteria in soil and survival of pathogenic bacteria in the environment. Research work focuses on understanding the ecological roles for specific bacterial activities including antibiotic production, resistance and exoenzyme production and analysing the impact of lateral gene transfer. During the past decade expertise has been developed in the detection, quantification and analysis of soil microbial communities, including the identification of pathogen reservoirs outside of their hosts. Her group was one of the first to report the molecular detection of antibiotic biosynthesis in soil and co-evolution of resistance in non-producers. Subsequent work indicated that waste disposal practices further disseminate antibiotic resistance gene into the environment. Studying the fate of introduced bacteria in the environment has focused on the survival of pathogens such as Salmonella species, MRSA, Dichelobacter nodosus and slow growing mycobacteria including the M. tuberculosis complex. Recent research produced the first non-invasive methods for monitoring shedding in wild life and cattle infected with bTB in order to elucidate the impact of control measures on transmission.

研究领域

Antibiotic resistance dissemination, aim to identify reservoirs of drug resistance in the environment Defining environmental reservoirs of pathogenic bacteria in soil and water Biodegradation of recalcitrant compounds and biopolymers in the environment Microbial community analysis and specific expertise in the development of environmental proteomics for extraction and analysis of enzymes from soils and wastes, and in the processing of biopolymers Metagenomics and analyses of microbial gene pools in soil; discovery of novel antibiotic gene clusters

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Cruz, Jo ão C. S., Maffioli, Sonia I., Bernasconi, Alice, Brunati, Cristina, Gaspari, Eleonora, Sosio, Margherita, Wellington, E. M. H., Donadio, Stefano. 2016. Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus. The Journal of Antibiotics, View Gudeta, Dereje Dadi, Bortolaia, Valeria, Amos, Gregory C. A., Wellington, E. M. H., Brandt, Kristian K., Poirel, Laurent, Nielsen, Jesper Boye, Westh, Henrik, Guardabassi, Luca. 2016. The soil microbiota harbors a diversity of Carbapenem-Hydrolyzing ß-Lactamases of potential clinical relevance. Antimicrobial Agents and Chemotherapy, 60 (1), pp. 151-160, View Lidbury, Ian, Murphy, Andrew, Scanlan, David J., Bending, Gary D., Jones, Alexandra M., Moore, Jonathan D., Goodall, Amanda, Hammond, John P., Wellington, E. M. H.. 2016. Comparative genomic, proteomic and exoproteomic analyses of three Pseudomonas strains reveals novel insights into the phosphorus scavenging capabilities of soil bacteria. Environmental Microbiology, 18 (10), pp. 3535-3549, View Salimraj, Ramya, Zhang, Lihong, Hinchliffe, Philip, Wellington, E. M. H., Brem, Jürgen, Schofield, Christopher J., Gaze, William H., Spencer, James. 2016. Structural and biochemical characterization of Rm3, a subclass B3 Metallo-ß-Lactamase identified from a functional metagenomic study. Antimicrobial Agents and Chemotherapy, 60 (10), pp. 5828-5840, View Cleary, David W., Bishop, Alistair H., Zhang, Lihong, Topp, Edward, Wellington, E. M. H., Gaze, William H., Smalla, Kornelia. 2016. Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. FEMS Microbiology Ecology, 92 (10), View Lehmann, Katja, Bell, Thomas, Bowes, Michael J., Amos, Gregory C. A., Gaze, William H., Wellington, E. M. H., Singer, Andrew C.. 2016. Trace levels of sewage effluent are sufficient to increase class 1 integron prevalence in freshwater biofilms without changing the core community. Water Research, 106, pp. 163-170, View Witcomb, Luci, Green, Laura E., Calvo-Bado, Leo A., Russell, Claire, Smith, Edward M., Grogono-Thomas, Rose, Wellington, E. M. H.. 2015. First study of pathogen load and localisation of ovine footrot using fluorescence in situ hybridisation (FISH). Veterinary Microbiology, Volume 176 (Number 3-4), pp. 321-327, View Roca, Ignasi, Akova, Murat, Baquero, F., Carlet, Jean, Cavaleri, Marco, Coenen, Samuel, Cohen, J., Findlay, D., Gyssens, Inge, Heure, O. E., Kahlmeter, Gunnar, Kruse, H., Laxminarayan, Ramanan, Liébana, Ernesto, Là³pez-Cerero, Lorena, MacGowan, Alasdair, Martins, Marta, Rodràguez-Baà±o, Jesus, Rolain, Jean-Marc, Segovia, Carlos, Sigauque, Betuel, Taconelli, E., Wellington, E. M. H., Vila, Jordi. 2015. The global threat of antimicrobial resistance : science for intervention. New Microbes and New Infections, 6, pp. 22-29, View