研究领域
Aminoacyl-tRNA synthetases
Bacterial Cell Wall Biosynthesis
Bacterial Cell Division
Antimicrobial Drug Discovery
Track record: David Roper is a former MRC Career Development Award fellow at the University of York and now reader in Structural Biology at the University Warwick.
The Roper group uses structural biology techniques, principally X-ray structural determination, in combination with molecular biology and biochemical approaches, to investigate the molecular basis of microbial physiology in relation to antimicrobial resistance.
Current areas of research include and bacterial cell wall (peptidoglycan) biosynthesis, bacterial cell division and antibiotic resistance signalling systems as well as targetting tRNA synthetases in bacterial pathogens. His research encompasses fundamental and translation approaches including assay development and drug discovery approaches. In addition, his research group also uses a synthetic and systems biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation.
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Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, Košmrlj, Janez, Dowson, Christopher G.. 2017. Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127, pp. 223-234, View
Calvez, Philippe, Breukink, Eefjan, Roper, David I., Dib, Mélanie, Contreras-Martel, Carlos, Zapun, André. 2017. Substitutions in PBP2b from ß-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity. Journal of Biological Chemistry, View
Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A., Besra, Gurdyal S.. 2016. Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6, View
Broughton, Claire, Berg, Hugo van den, Wemyss, Alan M., Roper, David I., Rodger, Alison. 2016. Beyond the discovery void : new targets for antibacterial compounds. Science Progress, 99 (2), pp. 153-182, View
Kaner, Rebecca A., Allison, Simon A., Faulkner, Alan D., Simpson, Daniel H., Waterfield, Nicholas R., Phillips, Roger M., Roper, David I., Shepherd, Samantha L., Scott, Peter. 2016. Anticancer metallohelices : nanomolar potency and high selectivity. Chemical Science, 7 (2), pp. 951-958, View
Li, Qiong, Cheng, Wang, Morlot, Cécile, Bai, Xiao-Hui, Jiang, Yong-Liang, Wang, Wenjia, Roper, David I., Vernet, Thierry, Dong, Yu-Hui, Chen, Yuxing, Zhou, Cong-Zhao. 2015. Full-length structure of the major autolysin LytA. Acta Crystallographica Section D Biological Crystallography, 71 (6), pp. 1373-1381, View
Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne E., Meutermans, Wim, Cooper, M. A. (Matthew A.). 2015. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6, pp. 1-11, View
Teo, Alvin, Roper, David I.. 2015. Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities. Antibiotics, 4 (4), pp. 495-520, View