Jaramillo, Alfonso - University of Warwick - Department of Biomedical Science

个人简介

After a PhD in Particle Physics (1999), AJ he worked on the computational design of proteins, using molecular modeling techniques. Afterwards, after moving as Assistant Professor to Ecole Polytechnique, he developed computational design methods for metabolic networks, transcriptional networks, and particularly RNA networks. In 2009, after moving to CNRS-Genopole as senior researcher, he started his experimental microbiology lab where he could validate experimentally his computational methodologies. He then developed and used automated microscopy and microfluidics chips for single-cell validations. In 2013, he moved to the University of Warwick as Full Professor, where he is developing new cell-culture bioreactors for directed evolution, which he applies to engineer the first synthetic bacteriophage. He also is developing a novel gene regulation relying on RNA. He has coordinated several Synthetic Biology international consortia and he is member of the editorial boards of ACS Synthetic Biology and the J. of Biol. Engineering.

研究领域

Engineering organism-specific virus-like antibiotics. Engineering synthetic RNA circuits in living cells.

近期论文

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Rodrigo, Guillermo, Prakash, Satya (Researcher in Life Sciences), Cordero, Teresa, Kushwaha, Manish, Jaramillo, Alfonso. 2016. Functionalization of an antisense small RNA. Journal of Molecular Biology, 428 Part B (5), pp. 889-892, View Sagona, Antonia, P., Grigonyte, Aurelija M., MacDonald, Paul, Jaramillo, Alfonso. 2016. Genetically modified bacteriophages. Integrative Biology, 8, pp. 465-474, View Kushwaha, Manish, Rostain, William, Prakash, Satya (Researcher in Life Sciences), Duncan, John, Jaramillo, Alfonso. 2016. Using RNA as molecular code for programming cellular function. ACS Synthetic Biology, 5 (8), pp. 795-809, View Shen, Shensi, Rodrigo, Guillermo, Prakash, Satya (Researcher in Life Sciences), Majer, Eszter, Landrain, Thomas E., Kiro, Boris, Daros, Jose-Antonio, Jaramillo, Alfonso. 2015. Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression. Nucleic Acids Research, 43 (10), pp. 5158-5170, View Amos, Martyn, Axmann, Ilka Maria, Blüthgen, Nils, de la Cruz, Fernando, Jaramillo, Alfonso, Rodriguez-Paton, Alfonso, Simmel, Friedrich. 2015. Bacterial computing with engineered populations. Philosophical Transactions of the Royal Society A: Mathematical, Physica and Engineering Sciences, 373 (2046), View Rodrigo, Guillermo, Majer, Eszter, Prakash, Satya (Researcher in Life Sciences), Daros, Jose Antonio, Jaramillo, Alfonso, Poyatos, Juan F.. 2015. Exploring the dynamics and mutational landscape of riboregulation with a minimal synthetic circuit in living cells. Biophysical Journal, 109 (5), pp. 1070-1076, View Pasini, Martina, Fernà¡ndez-Castané, Alfred, Jaramillo, Alfonso, de Mas, Carles, Caminal, Gloria, Ferrer, Pau. 2015. Using promoter libraries to reduce metabolic burden due to plasmid-encoded proteins in recombinant Escherichia coli. New Biotechnology, 33 (1), pp. 78-90, View Rodrigo, Guillermo, Jaramillo, Alfonso. 2014. RiboMaker : computational design of conformation-based riboregulation. Bioinformatics, Volume 30 (Number 17), pp. 2508-2510, View