Anderson, Emma - University of Warwick - Department of Biomedical Science

个人简介

After graduating from Oxford in 1997 with a first class degree in Biochemistry, I moved to Cambridge to study for my PhD under the supervision of Professor Richard Jackson. My work on the translation of human rhinovirus RNA was the beginning of my interest in translation mechanisms and viruses. In 2001 I moved to The Scripps Research Institute, La Jolla, USA to work as a postdoctoral fellow with Dr Stephen Mayfield on light-regulated translation in Chlamydomonas reinhardtii. I returned to Cambridge in 2004 to work with Professor Andrew Lever in the Department of Medicine on the regulation of translation of HIV-1. In 2007 I was appointed as an Assistant Professor in Virology at Warwick, where I have continued my interest in translation mechanisms of important viruses such as HIV and influenza.

研究领域

Viruses do not encode their own protein synthesis machinery, but must hijack that of their host cell. Viral mRNAs are vastly outnumbered by cellular mRNAs and therefore many viruses have evolved novel mechanisms to preferentially recruit ribosomes. We are interested in the mechanisms by which retroviruses such as HIV are able to recruit ribosomes to their RNAs at the right time to make the proteins they need for new viral particles. Due to the compact nature of their genomes, many viruses encode several proteins from one mRNA. We are also interested in the mechanisms that viruses employ to direct translation of different proteins from one RNA molecule. Understanding of these novel translation mechanisms will not only open up new avenues for treatment of viral infection, but also shed light on cellular protein synthesis. Loss of control of cellular translation has been shown to contribute to diseases such as diabetes and cancer.

近期论文

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Ray, Swagat, Anderson, Emma C.. 2016. Stimulation of translation by human Unr requires cold shock domains 2 and 4, and correlates with poly(A) binding protein interaction. Scientific Reports, 6, View Alford, Justine E., Marongiu, Michela, Watkins, Gemma L., Anderson, Emma C.. 2016. Human immunodeficiency virus type 2 (HIV-2) Gag is trafficked in an AP-3 and AP-5 dependent manner. PLoS One, 11 (7), View Ray, Swagat, Catnaigh, Pà³l à“, Anderson, Emma C.. 2015. Post-transcriptional regulation of gene expression by Unr. Biochemical Society Transactions, 43 (3), pp. 323-327, View Anderson, Emma C., Catnaigh, Pà³l à“.. 2015. Regulation of the expression and activity of Unr in mammalian cells. Biochemical Society Transactions, 43 (6), pp. 1241-1246, View Alford, Justine E., Gumbs, Jade, Anderson, Emma C.. 2014. A new role for clathrin adaptor proteins 1 and 3 in lipoplex trafficking. PLoS ONE, Volume 9 (Number 3), View Wise, Helen M., Barbezange, Cyril, Jagger, Brett W., Dalton, Rosa Maria, Gog, Julia R., Curran, Martin D., Taubenberger, Jeffery, Anderson, Emma C., Digard, Paul. 2011. Overlapping signals for translational regulation and packaging of influenza A virus segment 2. Nucleic Acids Research, Vol.39 (No.17), pp. 7775-7790, View Wise, Helen M., Foeglein, Agnes, Sun, Jiechao, Dalton, Rosa Maria, Patel, Sheetal, Howard, Wendy, Anderson, Emma C., Barclay, Wendy S., Digard, Paul. 2009. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. Journal of Virology, Vol.83 (No.16), pp. 8021-8031, View Groom, Harriet C. T., Anderson, Emma C., Dangerfield, John A., Lever, Andrew M. L.. 2009. Rev regulates translation of human immunodeficiency virus type 1 RNAs. Journal of General Virology, Vol.90 (Part 5), pp. 1141-1147, View Anderson, Emma C., Hunt, Sarah L., Jackson, Richard J.. 2007. Internal initiation of translation from the human rhinovirus-2 IRES requires the binding of Unr to two distinct sites on the 5' UTR. Journal of General Virology, Vol.88 (No.11), pp. 3043-3052, View