Nokes, James - University of Warwick - Department of Biomedical Science

研究领域

We have a programme of research that focuses on the investigation of patterns of infection of viruses of medical importance (eg measles, rubella, hepatitis B and respiratory syncytial viruses), predominantly in developing countries (Ethiopia and Kenya). The central objectives are to develop understanding of the factors determining infection dynamics, in relation to host behaviour and demography, and parasite strain structure, and to provide a framework for optimising the design of control programmes. Projects involve a combination of data collection (eg community based sampling of serum, saliva and respiratory fluids), laboratory analysis (serology and molecular genotyping) and mathematical and statistical modelling. Field projects are currently underway in Ethiopia and Kenya. The research is multidisciplinary and collaborative, with applications to public health policy.

近期论文

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Pan-Ngum, Wirichada, Kinyanjui, Timothy M., Kiti, Moses C., Taylor, Sylvia, Toussaint, Jean-François, Saralamba, Sompob, Van Effelterre, Thierry, Nokes, D. James, White, Lisa J.. 2017. Predicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles : a consensus modelling approach. Vaccine, 35 (2), pp. 403-409, View Kamau, Everlyn, Agoti, Charles N., Lewa, Clement S., Oketch, John, Owor, Betty E., Otieno, Grieven P., Bett, Anne, Cane, Patricia A., Nokes, D. James. 2017. Recent sequence variation in probe binding site affected detection of respiratory syncytial virus group B by real-time RT-PCR. Journal of clinical virology, View Emukule, Gideon O., Mott, Joshua A., Spreeuwenberg, Peter, Viboud, Cecile, Commanday, Alexander, Muthoka, Philip, Munywoki, Patrick K., Nokes, D. James, Velden, Koos van der, Paget, John W.. 2016. Influenza activity in Kenya, 2007-2013 : timing, association with climatic factors, and implications for vaccination campaigns. Influenza and Other Respiratory Viruses, View Kiti, Moses C., Tizzoni, Michele, Kinyanjui, Timothy M., Koech, Dorothy C., Munywoki, Patrick K., Meriac, Milosch, Cappa, Luca, Panisson, André, Barrat, Alain, Cattuto, Ciro, Nokes, D. James. 2016. Quantifying social contacts in a household setting of rural Kenya using wearable proximity sensors. EPJ Data Science, 5 (1), View Owor, Betty E., Masankwa, Geoffrey N., Mwango, Lilian C., Njeru, Regina W., Agoti, Charles N., Nokes, D. James. 2016. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya, 2007-11. BMC Infectious Diseases, 16 (1), View Agoti, Charles N., Kiyuka, Patience K., Kamau, Everlyn, Munywoki, Patrick K., Bett, Anne, van der Hoek, Lia, Kellam, Paul, Nokes, D. James, Cotten, Matthew. 2016. Human Rhinovirus B and C genomes from rural coastal Kenya. Genome Announcements, 4 (4), pp. 1-2, View Otieno, James R., Agoti, Charles N., Gitahi, Caroline W., Bett, Ann, Ngama, Mwanajuma, Medley, Graham F, Cane, Patricia A., Nokes, D. James. 2016. Molecular evolutionary dynamics of respiratory syncytial virus group A in recurrent epidemics in coastal Kenya. Journal of Virology, 90 (10), pp. 4990-5002, View Adetifa, Ifedayo M.O., Bwanaali, Tahreni, Wafula, Jackline, Mutuku, Alex, Karia, Boniface, Makumi, Anne, Mwatsuma, Pauline, Bauni, Evasius, Hammitt, Laura L., Nokes, D. James, Maree, Ephantus, Tabu, Collins, Kamau, Tatu, Mataza, Christine, Williams, Thomas N., Scott, J. Anthony G.. 2016. Cohort profile : the Kilifi vaccine monitoring study. International Journal of Epidemiology, View Nyiro, Joyce Uchi, Sande, Charles Jumba, Mutunga, Martin, Kiyuka, Patience Kerubo, Munywoki, Patrick Kioo, Scott, John Anthony G., Nokes, D. James. 2016. Absence of association between cord specific antibody levels and severe respiratory syncytial virus (RSV) disease in early infants : a case control study from coastal Kenya. PLoS One, 11 (11), View