Dowson, Chris - University of Warwick - Department of Biomedical Science

个人简介

BSc (hons) Applied Biology, Bath University 1982. PhD Microbiology, Bath University 1988

研究领域

The Infectious Disease Research Group is part of the Controlling Infection theme within the School of Life Sciences at the University of Warwick but has a wide range of research links with other groups across Warwick and beyond. The Infectious Disease Research Group is located within a first class research department (grade 5), with extensive facilities for molecular and analytical techniques, recently bolstered by a significant investment from the Regional Development Agency, AWM. The principal objectives of the group are to characterise the molecular genetic attributes which are responsible for the pathogenic properties and antibiotic resistance of a diverse range of human and animal pathogens, understand the evolution of them and open up novel therapeutic strategies. There are substantial interactions with groups working in Protein Structure (D.I. Roper), Chemistry (T.D.H.Bugg) and Engineering (M Chappell, N. Evans) developing a better understanding of cell wall biosynthesis, using both classical biochemistry and systems biology approaches. We have expanding interests in the development of novel diagnostic tools and point of care devices in collaborations with Micropathology Ltd. the Department of Engineering (J. Gardner, J. Covington, M. Cole) and Sarissa Ltd (N. Dale). We have an ongoing interest in the improvement of and detection of contamination within industrial processes in collaboration with MSL Ltd (C.Dow), and also in developing advanced process control systems through Biotek Ltd. Alongside this we are taking novel approaches to improve the microbial process in next generation anaerobic digesters alongside collaborators in Chemistry (A. Marsh and P. Taylor).

近期论文

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Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, KoÅ¡mrlj, Janez, Dowson, Christopher G.. 2017. Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127, pp. 223-234, View Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A., Besra, Gurdyal S.. 2016. Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6, View Nelson, E Andrea, Wright-Hughes, Alexandra, Brown, Sarah, Lipsky, Benjamin A, Backhouse, Michael, Bhogal, Moninder, Ndosi, Mwidimi, Reynolds, Catherine, Sykes, Gill, Dowson, Christopher G., Edmonds, Michael, Vowden, Peter, Jude, Edward B., Dickie, Tom, Nixon, Jane. 2016. Concordance in diabetic foot ulceration : a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers. Health Technology Assessment, 20 (82), View Smith, Nicholas A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G., Sadler, P. J.. 2016. Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1), pp. 395-404, View Dowson, Christopher G., O'Reilly, Steven. 2016. DNA methylation in fibrosis. European Journal of Cell Biology, 95 (9), pp. 323-330, View Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne E., Meutermans, Wim, Cooper, M. A. (Matthew A.). 2015. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6, pp. 1-11, View Dobrzanska, Dorota A., Cooper, A. (Amy), Dowson, Christopher G., Evans, Stephen D., Fox, D. J. (David J.), Johnson, Benjamin R., Biggs, Caroline I., Randev, Rajan, Stec, Helena M., Taylor, Paul C., Marsh, Andrew. 2013. Oxidation of tertiary amine-derivatized surfaces to control protein adhesion. Langmuir, Volume 29 (Number 9), pp. 2961-2970, View