Leppard, Keith - University of Warwick - Department of Biomedical Science

个人简介

After gaining my first degree in Biochemistry from Oxford, U.K., I began my research career studying for a PhD with Dr Lionel Crawford, working in the labs of what was then the Imperial Cancer Research Fund (now Cancer Research UK) at Lincolns Inn Fields, London. This work focused on the then newly discovered cellular tumour suppressor protein, p53, which was being studied in the context of SV40 infection. From there I moved to a postdoctoral position with Prof Tom Shenk, first at SUNY Stony Brook and then at Princeton. There I learned the adenovirus genetic system that I have worked on ever since. I left Princeton in 1988 to take up a lectureship in the Department of Biological Sciences, University of Warwick, where I am now an Associate Professor (Reader). I have a broad interest in adenovirus molecular and cell biology and my work has made several major contributions to this field. A particular focus has been the functions of the proteins encoded by the viral E1B and E4 genes, and most recently the L4 gene, in controlling viral gene expression and the biology of the host cell. My studies of E4 proteins have led me into a exploring the diversity and function of host cell PML proteins. These proteins are crucial in many aspects of cell function, particularly the innate immune response. A further significant strand of recent work has been in the development of adenovirus as a vector for gene delivery. I have co-authored a successful undergraduate textbook, Introduction to Modern Virology, with Prof. Nigel Dimmock and Prof. Andrew Easton. The brand new 7th edn. is recently published and available from booksellers from 19 February 2016.

研究领域

My research group studies various aspects of adenovirus cell and molecular biology. Our current research aims are: to understand the interactions of adenovirus with its host cell at the molecular level, particularly the innate responses of the cell to infection to gain insight into the relationship between cellular stress responses and infection to understand how adenovirus late gene expression is controlled in productive infections and reactivation from latency in lymphoid cells to use our knowledge of adenoviruses to generated improved adenovirus vectors for gene therapy and recombinant vaccine delivery

近期论文

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Windheim, Mark, Höning, Stefan, Leppard, Keith, Butler, Larrisa, Seed, Christina, Ponnambalam, Sreenivasan, Burgert, Hans-Gerhard. 2016. Sorting motifs in the cytoplasmic tail of the immunomodulatory E3/49K protein of species D adenoviruses modulate cell surface expression and ectodomain shedding. Journal of Biological Chemistry, 291, pp. 6796-6812, View Bridges, Rebecca G., Sohn, Sook-Young, Wright, Jordan L., Leppard, Keith, Hearing, Patrick. 2016. The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal degradation. mBio, 7 (1), View Atwan, Zeenah, Wright, Jordan L., Leppard, Keith, Woodman, Andrew. 2016. Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response. Journal of General Virology, 97, pp. 1955-1967, View Chen, Yixiang, Wright, Jordan L., Meng, Xueqiong, Leppard, K. N. (Keith N.). 2015. Promyelocytic leukemia protein isoform II promotes transcription factor recruitment to activate interferon ß and interferon-responsive gene expression. Molecular and Cellular Biology, Volume 35 (Number 10), pp. 1660-1672, View Wright, Jordan L., Atwan, Zeenah, Morris, S. J. (Susan J.), Leppard, K. N. (Keith N.). 2015. The human adenovirus type 5 L4 promoter is negatively regulated by TFII-I and by L4-33K. Journal of Virology, Volume 89 (Number 14), pp. 1-36, View Maunder, Helen E., Taylor, Geraldine, Leppard, K. N. (Keith N.), Easton, A. J. (Andrew J.). 2015. Intranasal immunisation with recombinant adenovirus vaccines protects against a lethal 2 challenge with pneumonia virus of mice. Vaccine, 33 (48), pp. 6641-6649, View Wright, Jordan, Leppard, K. N. (Keith N.). 2013. The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53. Journal of Virology, Volume 87 (Number 21), pp. 11617-11625, View Morris, S. J. (Susan J.), Scott, Gillian E., Leppard, K. N. (Keith N.). 2010. Adenovirus late phase infection is controlled by a novel L4 promoter. Journal of Virology, Vol.84 (No.14), pp. 7096-7104, View Morris, S. J. (Susan J.), Farley, Daniel C., Leppard, K. N. (Keith N.). 2010. Generation of cell lines to complement Adenovirus vectors using recombination-mediated cassette exchange. BioMed Central Ltd., Vol.10 (No.92), View