Koentges, Georgy - University of Warwick - Department of Biomedical Science

个人简介

1988: German High-school (Apostelgymnasium), focus on Classics and Biology 1988-1989 Military service, German Army. 1989-1997: Fellow of German National Scholarship Foundation (Studienstiftung des Deutschen Volkes) for undergraduate and PhD studies. 1989-1994 Studies in Tuebingen and Freiburg: Trained in comparative vertebrate anatomy, genetics, palaeontology, vertebrate embryology and (largely) Greek philosophy. Diplombiologe (equivalent to BSc) 1994-1997:PhD with Professor Andrew Lumsden FRS in vertebrate embryology: Work on the role of neural crest in craniofacial pattern. This work discovered how neural crest segmentation is maintained in the segmentally specific pattern of skeleto-muscular connections, it has taught us how muscles get anchored to the right places in the skull. This work was awarded the Thomas Henry Huxley Prize 1998 for the best zoological PhD thesis in the UK/N.Ireland. 1997-2001: Human Frontiers Long term fellow and BASF special postdoctoral fellow at Harvard University. Also awarded EMBO fellowship (but I declined it). Work with Professor Catherine Dulac (Harvard) and Nobel Prize winner Richard Axel on the development and wiring of the olfactory system (pheromonal perception system): work on genetically tracing neuronal circuitry. Development of novel methods to expression-profile single cells on microarrays using laser-capture microscopy, a technique still being used in the lab. April 2001-March 2007: Senior Lecturer in Functional Genomics and Evolutionary biology at UCL (WIBR). Discovery of a novel origin of the neck and shoulder region (Matsuoka et al. Nature 2005). Refocus of work into areas of gene-regulation within stem cells. 2 Wellcome Trust Programme Grants, 1BBSRC Project grant, 1 ARC grant, several smaller grants. Since April 2007: Professor of Genomic Systems Biology and Evolution,University of Warwick, School of Life Sciences Human Frontiers Programme Grant (as Principle Investigator), 2 MRC grants, 2 ConquerChiari project grants, one Column of Hope grant. Focus on fundamental aspects of gene regulation and how these relate to anatomical features and how these have been subjected to evolutionary change of craniofacial structrues. Work on the genetic foundation of the Arnold-Chiari malformation as a neurocristopathy, supported by ConquerChiari through two project grants and a grant by Column of Hope. A most recent MRC project grant (starting Dec 2015 for 4 yrs) with my colleague Prof Nick Dale will examine the role of neural crest lineages in postnatal and adult breathing control.

研究领域

We are interested in deciphering the complex signalling relationships between the developing skull and the underlying brain by combining the power of developmental genetics, lineage analysis and in vivo single cell imaging across vertebrate systems. One key organizing tissue, the embryonic neural crest, has been the focus of my attention for the past 2 decades. Understanding how it interacts and builds complex patterns of bones and muscles and what it influences (i.e. the brain) and how this has changed over hundreds of millions of years is a great challenge. Deciphering this has relevance for the deep evolution of the vertebrate skeleton & the skeletomuscular system. This also pertains to understanding the exact causes and time courses responsible for devastating human craniofacial ailments such as microcephaly, sometimes caused by viruses such as Zika.

近期论文

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Vance, Keith W., Woodcock, Dan J., Reid, John E., Bretschneider, Till, Ott, Sascha, Koentges, Georgy. 2015. Conserved cis-regulatory modules control robustness in Msx1 expression at single-cell resolution. Genome Biology and Evolution, 7 (9), pp. 2762-2778, View Woodcock, Dan J., Vance, Keith W., Komorowski, Michal, Koentges, Georgy, Finkenstädt, Bärbel, Rand, D. A. (David A.). 2013. A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number. Bioinformatics, Volume 29 (Number 12), pp. 1519-1525, View Jeziorska, Danuta M., Koentges, Georgy, Vance, K. W.. 2012. Novel cis-regulatory modules control expression of the hairy and enhancer of split-1 (HES1) transcription factor in myoblasts. Journal of Biological Chemistry, Vol.287 (No.8), pp. 5687-5697, View Downey, Mike J., Jeziorska, Danuta M., Ott, Sascha, Tamai, T. Katherine, Koentges, Georgy, Vance, Keith W., Bretschneider, Till. 2011. Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution. PLoS ONE, Vol.6 (No.12), View Granier, Céline, Gurchenkov, Vasily, Perea-Gomez, Aitana, Camus, Anne, Ott, Sascha, Papanayotou, Costis, Iranzo, Julian, Moreau, Anne, Reid, John, Koentges, Georgy, Sabéran-Djoneidi, Délara, Collignon, Jérà´me. 2011. Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo. Developmental Biology, Vol.349 (No.2), pp. 350-362, View Koentges, Georgy. 2010. Journal club. A genomic systems biologist muses on how shared DNA mistakes reveal shared cellular ancestry. Nature, Vol.467 (No.7313), pp. 255-255, View Koohy, Hashem, Dyer, Nigel, Reid, John E., Koentges, Georgy, Ott, Sascha. 2010. An alignment-free model for comparison of regulatory sequences. Bioinformatics, Vol.26 (No.19), pp. 2391-2397, View Koentges, Georgy. 2008. Evolution of anatomy and gene control. Nature, Volume 451 (Number 7179), pp. 658-663, View