Hebenstreit, Daniel - University of Warwick - Department of Biomedical Science

研究领域

My group is working on the mechanisms of transcriptional regulation in metazoan cells. We are interested in several aspects of this, including the interplay of epigenetics and transcription, the role of 'noise' in gene and protein expression, and the reorganization of transcriptional networks upon differentiation. To study these subjects, we are employing a systems-biology approach based on accurate experimental quantification with next-generation sequencing technologies such as mRNA-seq and ChIP-seq, studying cell population diversity with flow cytometry, and statistical and mathematical analysis of the data. We focus on the system of murine T helper cells, particularly the Th2 subtype, which provides a valuable model for mammalian cell differentiation and is experimentally accessible.

近期论文

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Xie, Xin, Stubbington, Michael J. T., Nissen, Jesper K., Andersen, Kristian G., Hebenstreit, Daniel, Teichmann, Sarah A., Betz, Alexander G.. 2015. The regulatory T Cell lineage factor Foxp3 regulates gene expression through several distinct mechanisms mostly independent of direct DNA binding. PLoS Genetics, Volume 11 (Number 6), View Mahata, Bidesh, Zhang, Xiuwei, Kolodziejczyk, Aleksandra A., Proserpio, Valentina, Haim-Vilmovsky, Liora, Taylor, Angela E., Hebenstreit, Daniel, Dingler, Felix A., Moignard, Victoria, Göttgens, Berthold, Arlt, Wiebke, McKenzie, Andrew N. J., Teichmann, Sarah A.. 2014. Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis. Cell Reports, Volume 7 (Number 4), pp. 1130-1142, View Rebhandl, S., Huemer, M., Gassner, F. J., Zaborsky, N., Hebenstreit, Daniel, Catakovic, K., Grössinger, E. M., Greil, R., Geisberger, R.. 2014. APOBEC3 signature mutations in chronic lymphocytic leukemia. Leukemia, Volume 28 (Number 9), pp. 1929-1932, View Huemer, Michael, Rebhandl, Stefan, Zaborsky, Nadja, Gassner, Franz, Hainzl, Stefan, Weiss, Lukas, Hebenstreit, Daniel, Greil, Richard, Geisberger, Roland. 2014. AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells. European Journal of Immunology, Volume 44 (Number 12), pp. 3747-3757, View Hebenstreit, Daniel. 2013. Are gene loops the cause of transcriptional noise?. Trends in Genetics, Volume 29 (Number 6), pp. 333-338, View Hebenstreit, Daniel, Deonarine, Andrew, Babu, M. Madan, Teichmann, Sarah A.. 2012. Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells. Current Opinion in Cell Biology, Vol. 24 (No. 3), pp. 350-358, View Brookes, Emily, de Santiago, Inàªs, Hebenstreit, Daniel, Morris, Kelly J., Carroll, Tom, Xie, Sheila Q., Stock, Julie K., Heidemann, Martin, Eick, Dirk, Nozaki, Naohito, Kimura, Hiroshi, Ragoussis, Jiannis, Teichmann, Sarah A., Pombo, Ana. 2012. Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell, Vol. 10 (No. 2), pp. 157-170, View Hebenstreit, Daniel. 2012. Methods, challenges and potentials of single cell RNA-seq. Biology, Volume 1 (Number 3), pp. 658-667, View Hebenstreit, Daniel, Fang, Miaoqing, Gu, Muxin, Charoensawan, Varodom, van Oudenaarden, Alexander, Teichmann, Sarah A.. 2011. RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Molecular Systems Biology, Vol. 7, View Hebenstreit, Daniel, Teichmann, Sarah A.. 2011. Analysis and simulation of gene expression profiles in pure and mixed cell populations. Physical Biology, Vol. 8 (No. 3), View Hebenstreit, Daniel, Gu, M., Haider, S., Turner, D. J., Lio, P., Teichmann, Sarah A.. 2011. EpiChIP : gene-by-gene quantification of epigenetic modification levels. Nucleic Acids Research, Vol. 39 (No. 5), pp. e27-e27, View