Fullam, Elizabeth - University of Warwick - Department of Biomedical Science

个人简介

Sir Henry Dale Fellow, School of Life Sciences, University of Warwick, since October 2014 - present Leverhulme Trust Early Career Fellow, School of Life Sciences, University of Warwick, UK 2013-2014 Postdoctoral Research Fellow, School of Biosciences, University of Birmingham, UK, 2010-2013 Postdoctoral Research Fellow, Global Health Institute, EPFL, Switzerland. 2007-2010 DPhil, Departments of Pharmacology and Chemistry, University of Oxford, UK, 2004-2007 MSc Pharmacology, Department of Pharmacology, University of Oxford, UK MChem Chemistry, University of Oxford, UK

研究领域

I am interested in studying pathogenic mycobacteria. Current research in the lab is particularly focused on Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the single most important bacterial cause of morbidity and mortality in the world. Almost one-third of the world's population is infected with the TB bacillus and almost 2 million people die from TB each year. Treatment for TB is complicated and requires that at least three drugs be taken concomitantly for six to nine months, often with unpleasent side effects. Consequently a number of multi-drug and extensively-drug resistant strains for TB have emerged, which further complicates and prolongs treatment. In some cases no successful chemotherapy regimens remain. TB, in combination with immuno-comprimised individuals, particularly individuals with HIV, represents a serious health problem. Therefore there is an urgent need to understand how Mtb is able to survive and cause infection. My research is currently focused on understanding how Mtb uses and metabolises sugars using a multidisciplinary approach encompassing biochemistry, structural biology, chemistry and microbiology techniques. I am also interested in the development of novel antimicrobial agents and detection of infectious agents.

近期论文

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Fullam, Elizabeth, Prokes, Ivan, Fütterer, Klaus, Besra, Gurdyal S.. 2016. Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars. Open Biology (6), View Otten, Lucienne, Fullam, Elizabeth, Gibson, Matthew I.. 2016. Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile. Molecular BioSystems, 12 (2), pp. 341-344, View Lowery, Richard, Gibson, Matthew I., Thompson, Richard C., Fullam, Elizabeth. 2015. Deuterated carbohydrate probes as 'label-free' substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis. Chemical communications, 51 (23), pp. 4838-4841, View Gibson, Matthew I., Neres, Jo ão, Fullam, Elizabeth. 2014. Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor. Carbohydrate research, Volume 391, pp. 61-65, View Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S., Gibson, Matthew I.. 2014. Discrimination between bacterial phenotypes using glyco-nanoparticles and the impact of polymer coating on detection readouts. Journal of Materials Chemistry B, Volume 2 (Number 11), pp. 1490-1498, View Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela, Morris, Garrett, Finn, Paul, Sim, Edith. 2014. Exploration of piperidinols as potential antitubercular agents. Molecules, Volume 19 (Number 10), pp. 16274-16290, View Fullam, Elizabeth, Talbot, James, Abuhammed, Areej, Westwood, Isaac, Davies, Stephen G., Russell, Angela J., Sim, Edith. 2013. Design, synthesis and structureâ€“activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Vol.23 (No.9), pp. 2759-2764, View Otten, Lucienne, Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S., Gibson, Matthew I.. 2013. Gold nanoparticle-linked analysis of carbohydrateâ€“protein interactions, and polymeric inhibitors, using unlabelled proteins; easy measurements using a 'simple' digital camera. Journal of Materials Chemistry B, Volume 1 (Number 20), pp. 2665-2672, View Neres, J., Pojer, F., Molteni, E., Chiarelli, L. R., Dhar, N., Boy-Rottger, S., Buroni, S., Fullam, Elizabeth, Degiacomi, G., Lucarelli, A. P., Read, R. J., Zanoni, G., Edmondson, D. E., De Rossi, E., Pasca, M. R., McKinney, J. D., Dyson, P. J., Riccardi, G., Mattevi, A., Cole, S. T., Binda, C.. 2012. Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Science Translational Medicine, Vol.4 (No.150), View