研究领域
We exploit organic, polymer and carbohydrate chemistry to address global healthcare issues, with particular relevance to regenerative medicine and infectious diseases. This covers four main fields: Novel cryoprotectants for biological storage, inspired by antifreeze proteins; Biochemical and thermo-responsive polymers for targeted delivery applications; Materials approaches to glycomics for diagnosis and treament of infection; understanding nanoparticle interactions with cells. The work is highly interdisciplinary and our large and vibrant research group comprises of chemists, biochemists and biologists. We have dedicated facilities for all aspects including synthesis, recombinant protein expression and micrbobiology as well as analytical lab and cell culture. Professor Gibson is jointly appoiinted between Chemistry and Warwick Medical School.
近期论文
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Mitchell DE., Lovett JR, Armes SP and Gibson MI, Angewandte Chemie, 2016, "Biomimetic Block Copolymer Worms Combined with an Ice-Inhibiting Polymer Enable Solvent-Free Cryopreservation of Red Blood Cells" Online
Deller, R.C., Vatish, M., Mitchell, D.A., Gibson, M.I., Nature Communications, 2014, 5, 3244, "Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing"
Jones, MW, Otten, L, Richards, S-J, Lowery, R., Phillips DJ., Haddleton DM., and Gibson MI. Chemical Science. 2014 "Glycopolymers with Secondary Binding Motifs Mimic Glycan Branching and Display Bacterial Lectin Selectivity in Addition to Affinity" Online
Degradable Thermoresponsive Polymers which Display Redox-Responsive LCST Behaviour Phillips, D.J., Gibson, M. I.,Chemical Communications, 2012, 48 1054 - 1056.
Probing Bacterial Toxin Inhibition with Synthetic Glycopolymers using Tandem Post-Polymerization Modification: Role of Linker and Carbohydrate Density. Richards, S-J., Jones, MW, Hunaban, M., Haddleton, DM., Gibson, M.I., Angewandte Chemie. International Edition., 2012, 51, 7812-7816
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