Dixon, Ann - University of Warwick - Department of Chemistry

研究领域

Developing methods for describing the assembly, interactions and three-dimensional structures of membrane proteins using biophysical and computational techniques, including NMR spectroscopy. Of particular interest are membrane proteins associated with virally-induced cancers, which have demonstrated membrane protein-mediated mechanisms of cellular transformation.

近期论文

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Effects of the Oncogenic V664E Mutation on Membrane Insertion, Structure, and Sequence-dependent Interactions of the Neu Transmembrane Domain in Micelles and Model Memebranes: An Integrated Biophysical and Simulation Study, Beevers, A.J., Nash, A., Salazar-Cancino, M., Scott, D.J., Notman, R., Dixon, A.M., Biochemistry, 2012, 51, p. 2558-2568. Packing of Transmembrane Domain 2 of Carnitine Palmitoyltransferase-1A affects Oligomerization and Malonyl-CoA Sensitivity of the Mitochondrial Outer Membrane Protein, Jenei, Z.A., Warren, G.Z.L., Hasan, M., Zammit, V.A. and Dixon, A.M. , FASEB J, 2011, 25, p. 4522-4530. Towards a structural understanding of the smallest known oncoprotein: Investigation of the bovine papillomavirus E5 protein using solution-state NMR, King, G., Oates, J., Patel, D., van den Berg, H.A., Dixon, AM., Biochimica et Biophysica Acta - Biomembranes, 2011, 1808, 1493-1501. Evidence for Role of Transmembrane Helix-Helix Interactions in the Assembly of the Class II Major Histocompatibility Complex, King, G. and Dixon, A.M., Molecular BioSystems, 2010, 6, 1650-1661.