Corre, Christophe - University of Warwick

研究领域

Bacterial signalling: new chemical keys to unlock the production of novel microbial antibiotics. - Understanding the transcriptional regulation of antibiotic biosynthesis in actinomycete bacteria, from which more than 70% of clinically-approved antibiotics originate. - Exploiting signalling molecules (microbial hormones) to induce production of novel antibiotics in the laboratory environment

近期论文

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Discovery of a family of gamma-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. J.D. Sidda, L. Song, V. Poon, M. Al-Bassam, O. Lazos, M.J. Buttner, G.L. Challis and C. Corre. Chem. Sci., 2014, 5, 86-89. Regio- and stereodivergent antibiotic oxidative carbocyclizations catalyzed by Rieske oxygenase-like enzymes. P.K. Sydor, S. M. Barry, O.M. Odulate, F. Barona-Gomez, S.W. Haynes, C. Corre, L. Song, and G.L. Challis. Nat. Chem., 2011, 3, 388-392. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. L. Laureti, L. Song, S. Huang, C. Corre, P. Leblond, G.L. Challis and B. Aigle, Proc. Natl Acad. Sci. USA, 2011, 108, 6258-6263. Stereochemical elucidation of streptorubin B. S.W. Haynes, P.K. Sydor, C. Corre, L. Song, and G.L. Challis. J. Am. Chem. Soc., 2011, 133, 1793-98. A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols. C. Corre, S.W. Haynes, N. Malet, L. Song, and G.L. Challis. Chem. Commun., 2010, 46, 4079-4081. 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining C. Corre, L. Song, S. O'Rourke, K.F. Chater, G.L. Challis. Proc. Nat. Acad. Sci. USA. 2008, 105, 17510-17515.