Brosens, Jan - University of Warwick - Warwick Medical School

个人简介

Professor Jan Brosens' research centres on the role of steroid hormone signalling in the human endometrium, especially in the context of prevalent reproductive disorders, such as infertility, endometriosis and endometrial cancer. his major translational interest is focused on improving the management of miscarriage, the most common complication of pregnancy. He obtained a PhD from the University of London in 1999, working on the mechanisms underpinning the preparation of the lining of the womb (endometrium) for pregnancy, a process called decidualization. He was awarded a Wellcome Trust Clinical Scientist Fellowship in 1998, then joined Imperial College London as Chair of Reproductive Sciences in 2004 and became Chair of Reproductive Medicine in 2008. In May 2011 he was appointed as Chair of Obstetrics and Gynaecology at the University of Warwick.

研究领域

Professor Brosens' research centres on the role of steroid hormone signalling in the human endometrium, especially in the context of prevalent reproductive disorders, such as infertility, endometriosis and endometrial cancer. His major translational interest is focused on improving the management of miscarriage, the most common complication of pregnancy.

近期论文

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Tochigi, Hideno, Kajihara, Takeshi, Mizuno, Yosuke, Mizuno, Yumi, Tamaru, Shunsuke, Kamei, Yoshimasa, Okazaki, Yasushi, Brosens, Jan J., Ishihara, Osamu. 2017. Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells. Scientific Reports, 7, View Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J., Benagiano, G.. 2016. Origins and progression of adolescent endometriosis. Reproductive Sciences, View Lucas, Emma S., Dyer, Nigel, Fishwick, Katherine, Ott, Sascha, Brosens, Jan J.. 2016. Success after failure : the role of endometrial stem cells in recurrent miscarriage. Reproduction, pp. REP-16, View Brosens, Ivo, Benagiano, Giuseppe, Brosens, Jan J.. 2016. Endometriosis and obstetric syndromes : early diagnosis must become a priority. Fertility and Sterility, View Wongwananuruk, Thanyarat, Sato, Tomomi, Kajihara, Takeshi, Matsumoto, Sachiko, Akita, Masumi, Tamura, Kazuhiro, Brosens, Jan J., Ishihara, Osamu. 2016. Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture : a time-lapse study. Placenta, 47, pp. 56-62, View Salker, Madhuri S., Steel, Jennifer H., Hosseinzadeh, Zohreh, Nautiyal, Jaya, Webster, Zoe, Singh, Yogesh, Brucker, Sara, Lang, Florian, Brosens, Jan J.. 2016. Activation of SGK1 in endometrial epithelial cells in response to PI3K/AKT inhibition impairs embryo implantation. Cellular Physiology and Biochemistry, 39 (5), pp. 2077-2087, View Salker, Madhuri S., Hosseinzadeh, Zohreh, Alowayed, Nour, Zeng, Ni, Umbach, Anja T., Webster, Zoe, Singh, Yogesh, Brosens, Jan J., Lang, Florian. 2016. LEFTYA activates the epithelial Na+ Channel (ENaC) in endometrial cells via serum and glucocorticoid inducible kinase SGK1. Cellular Physiology and Biochemistry, 39 (4), pp. 1295-1306, View