Millar, Jonathan - University of Warwick

个人简介

I did my PhD with Dr. Enrique Rozengurt at the Cancer Research UK Laboratories in London (then ICRF) on signalling mechanisms in the early mitogenic response and then spent four years as post-doctoral fellow in the laboratory of Professor Paul Russell at The Scripps Research Institute in San Diego (U.S.A.). In 1994 I moved back to the U.K. to take up a tenure track position at the National Institute for Medical Research in London and received tenure in 2000. In 2006 I moved to the University of Warwick to take up a Professorship in Cell Biology.

研究领域

My laboratory has had a long-standing interest in the fundamental mechanisms that regulate the cell division cycle. We have made fundamental discoveries on how cells trigger entry into mitosis (Millar et al., 1991; Millar and Russell, 1992), how this transition is regulated by environmental stress (Millar et al., 1995, Là³pez-Avilés et al., 2005) and how cells ensure chromosomes are only replicated once per cell cycle (Wuarin et al., 2002). More recently we have uncovered novel factors required for the retrieval and bi-orientation of sister chromatids (Sanchez-Perez et al., 2005, Franco et al., 2007) and identified an evolutionarily conserved mechanism that switches of the spindle checkpoint (Vanoosthuyse et al., 2009; Meadows et al., 2011). I am currently a member of the Faculty of 1000 and an Editor of Seminars in Cell and Developmental Biology.

近期论文

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Meadows, John C., Lancaster, Theresa C., Buttrick, Graham J., Sochaj, Alicja, Messin, Liam J., Mora-Santos, Maria, Hardwick, Kevin G., Millar, Jonathan B. A.. 2017. Identification of a Sgo2-dependent but Mad2-independent pathway controlling anaphase onset in fission yeast. Cell Reports, View Mora-Santos, Maria, Hervas-Aguilar, Maria-America, Sewart, Katharina, Lancaster, Theresa C., Meadows, John C., Millar, Jonathan B. A.. 2016. Bub3-Bub1 binding to Spc7/KNL1 toggles the spindle checkpoint switch by licensing the interaction of Bub1 with Mad1-Mad2. Current Biology, 26 (19), pp. 2642-2650, View Hervas-Aguilar, Maria-America, Millar, Jonathan B. A.. 2016. Mph1/MPS1 checks in at the kinetochore. Cell Cycle, 15 (10), pp. 1313-1314, View Meadows, John C., Millar, Jonathan B. A.. 2015. Sharpening the anaphase switch. Biochemical Society Transactions, 43 (1), pp. 19-22, View Penfold, Christopher A., Millar, Jonathan B. A., Wild, David L.. 2015. Inferring orthologous gene regulatory networks using interspecies data fusion. Bioinformatics, 31 (12), pp. i97-i105, View Silià³, Virginia, McAinsh, Andrew D., Millar, Jonathan B. A.. 2015. KNL1-Bubs and RZZ provide two separable pathways for checkpoint activation at human kinetochores. Developmental Cell, 35 (5), pp. 600-613, View Sarkar, Sourav, Dalgaard, Jacob Z., Millar, Jonathan B. A., Arumugam, Prakash. 2014. The rim15-Endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast. PLoS Genetics, Volume 10 (Number 6), View Messin, Liam J., Millar, Jonathan B. A.. 2014. Role and regulation of kinesin-8 motors through the cell cycle. Systems and synthetic biology, Volume 8 (Number 3), pp. 205-213, View