Thumser, Alfred - University of Surrey - School of Biosciences and Medicine

个人简介

I grew up in the great city of Cape Town, South Africa, where I also attended the University of Cape Town to graduate eventually with a PhD from the Department of Medical Biochemistry. Subsequently, I spent some time working in the clinical laboratories, Wynberg Military Hospital; working on-call from Friday night until Monday morning was a good experience (e.g. diabetic patients keeping me the laboratory all night). Next stop was Southampton, where I worked on fatty acid-binding proteins with Prof David Wilton, which then led to a further post at Rutgers University, New Jersey, USA, with Prof Judy Storch. After eight years as post-doctoral research associate, I was offered the position of lecturer at the University of Surrey, first in the Division of Nutrition and now in the Department of Biochemistry & Physiology. A recent highlight has been a nomination for the University of Surrey Students Union “Best Lecturer” award and the Faculty of Health & Medical Sciences award of “Best Lecturer” in the Biological Sciences.

研究领域

Currently my research interests include endogenous and xenobiotic metabolism, toxicology and enzyme-linked electrochemistry. In terms of endogenous metabolism, I am a co-investigator on a BBSRC-funded project with Prof Debra Skene that is measuring the circadian rhythms of endogenous metabolites in blood and urine. The electrochemistry project is working on working enzyme-based fuel cells to potentially “power” small devices. Xenobiotic metabolism has focussed on elucidating the mechanisms of toxicity in idiosyncratic drugs, e.g. troglitazone.

近期论文

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Milton RD, Giroud F, Thumser AE, Minteer SD, Slade RCT. (2014) 'Glucose oxidase progressively lowers bilirubin oxidasebioelectrocatalytic cathode performance in single-compartmentglucose/oxygen biological fuel cells'. Electrochimica Acta, 140, pp. 59-64. doi: 10.1016/j.electacta.2014.02.058 Davies SK, Ang JE, Revell VL, Holmes B, Mann A, Robertson FP, Cui N, Middleton B, Ackermann K, Kayser M, Thumser AE, Raynaud FI, Skene DJ. (2014) 'Effect of sleep deprivation on the human metabolome.'. Proc Natl Acad Sci U S A, United States: 111 (29), pp. 10761-10766. doi: 10.1073/pnas.1402663111 Thumser AE, Moore JB, Plant NJ. (2014) 'Fatty acid binding proteins: Tissue-specific functions in health and disease'. Current Opinion in Clinical Nutrition and Metabolic Care, 17 (2), pp. 124-129. doi: 10.1097/MCO.0000000000000031