Plant, Kate - University of Surrey - School of Biosciences and Medicine

个人简介

I have worked at the University of Surrey since 2003, first as a post doctoral researcher and more recently as an RCUK Academic Fellow. My work at Surrey has focussed on changes in gene regulation in response to chemical insult, in particular alterations in the expression of nuclear import factors and drug metabolizing enzymes. History: I completed my PhD at the University of Nottingham, under the supervision of Dr Garry Morgan, studying gene regulation in the African clawed toad Xenopus laevis. Prior to arriving at Surrey I held two post doctoral positions; the first was at Guy's Hospital Paediatric Research Unit where I identified a number of causative mutations for the progressive kidney disease Alport Syndrome in the type IV collagen gene COL4A5. During my second post doctoral position I worked at the Sir William Dunn School of Pathology (Oxford) with Professor Nick Proudfoot, studying intergenic transcription in the human β-globin gene cluster.

研究领域

Nuclear Import projects: Regulation of karyopherin α by xenobiotics Translocation of nuclear receptors in hepatoma cells Nuclear import of Per3 polymorphic variants: in collaboration with Dr Simon Archer and Dr Malcolm von Schantz Mood Stabilizing Drugs: in collaboration with Dr Nick Plant Circadian aspects of statin toxicity: in collaboration with Dr Jonathan Johnston and Dr Nick Plant. PhD funded by the British Toxicology Society and the Centre for Toxicology Regulation of drug metabolising enzymes: in collaboration with Professor Costas Ioanides and Dr Nick Plant

近期论文

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PLANT, K.E., ANDERSON, E.A., SIMECEK, N., BROWN, R., FORSTER, S., SPINKS, J., TOMS, N., GIBSON, G.G., LYON, J. & PLANT, N. (2009) The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the activation of the homeodomain protein Six1. Toxicology and Applied Pharmacology, 235, 124-134 PUSHPARAJAH, D. S., UMACHANDRAN, M., PLANT, K. E., PLANT, N. & IOANNIDES, C. (2008) Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung. Mutagenesis 23: 299-308 PUSHPARAJAH, D. S., UMACHANDRAN, M., PLANT, K. E., PLANT, N. & IOANNIDES, C. (2008) Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 640: 153-161 PUSHPARAJAH, D.S., UMACHANDRAN, M., NAZIR, T., PLANT, K.E., PLANT, N., LEWIS, D.F.V. & IOANNIDES, C. (2008) Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicology In Vitro 22: 128-145 CHEEMA M.S., PLANT N.J., GIBSON G.G., & PLANT, K.E. (2007) Response of nuclear import factor encoding genes to xenobiotics: Analysis of the human karyopherin alpha 2 promoter. Toxicology, 240, 179-180 PUSHPARAJAH, D. S., UMACHANDRAN, M., PLANT, K. E., PLANT, N. & IOANNIDES, C. (2007) Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 231: 68-80. PLANT, K. E., EVERETT, D. M., GIBSON, G. G., LYON, J. & PLANT, N. J. (2006) Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Pharmacogenetics and Genomics 16: 647-658. OSKARSSON, A., ULLERAS, E., PLANT, K. E., HINSON, J. P. & GOLDFARB, P. S. (2006) Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. Journal of Applied Toxicology 26: 484-492.