Meira, Lisiane - University of Surrey - School of Biosciences and Medicine

个人简介

1984-1988 B.Sc., Biology. Federal University of Rio Grande do Sul, Porto Alegre/Brazil. 1989-1994 Ph.D., Genetics and Molecular Biology. Curie Institute, Paris/France & UFRGS, Porto Alegre/Brazil. 1995-2000 Postdoctoral Research Fellow/Instructor, UT Southwestern Medical Center, Texas, USA 2001-2008 Research Scientist, Harvard School of Public Health/Massachusetts Institute of Technology, MA, USA 2008-2009 Research Fellow, St. George’s University of London 2009-current Lecturer in Toxicology, University of Surrey

研究领域

My research focuses on understanding the mechanisms by which exposures to endogenous and/or exogenous toxicants lead to pathology and disease. In particular, I am interested in understanding how defective repair of DNA damage can affect health, with implications to human degenerative diseases associated with aging such as cancer and neuronal degeneration.

近期论文

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Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD. (2012) 'DNA repair is indispensable for survival after acute inflammation.'. J Clin Invest., 122 (7), pp. 2680-2689. doi: 10.1172/JCI63338 Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, Samson LD. (2009) 'Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.'. Proc Natl Acad Sci U S A, United States: 106 (3), pp. 888-893. doi: 10.1073/pnas.0807030106 Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD. (2009) 'O-6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106 (2), pp. 576-581. doi: 10.1073/pnas.0811991106 Meira LB, Bugni JM, Green SL, Lee C-W, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. (2008) 'DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice'. JOURNAL OF CLINICAL INVESTIGATION, 118 (7), pp. 2516-2525.