Manders, Ralph - University of Surrey - School of Biosciences and Medicine

个人简介

Ralph Manders received his Masters degree in Movement Sciences in 2003 from the Faculty of Health, Medicine & Life Sciences at Maastricht University, the Netherlands, before going on to complete a PhD focusing on the insulinotropic and anabolic properties of dietary protein in type 2 diabetes. He has been a post-doctoral researcher at both the faculties of Health, Medicine & Life Sciences at Maastricht University, the Netherlands and the Faculty of Kinesiology, KU Leuven, Belgium focussing on the beneficial health effects of exercise training and dietary modulation in type 2 diabetes and the elderly. He has also spend time as a visiting researcher at Prof. Martin Gibala’s lab at MacMaster University, Canada. Next to his research activities he has been involved in the supervision of several amateur and professional athletes with regard to performance and nutrition.

研究领域

On-going research interests are in the field of exercise training, nutrition, and energy/substrate metabolism and their role in improving health in (sub) clinical populations but also how these factors can improve exercise capacity and performance in athletes. With the use of continuous glucose monitoring devices (CGMS) we are able to test the impact of different exercise and dietary modulations on the level of glycemic control in (pre) diabetic populations as well as in athletes. My current research projects include exercise interventions aimed at improving glycemic control in type 2 diabetes patients and the role of leucine supplementation in overcoming anabolic resistance in the elderly.

近期论文

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van Loon, L.J., R. Koopman, R.J. Manders, W. van der Weegen, G.P. van Kranenburg, and H.A. Keizer (2004) Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab, 287(3):E558-65. Koopman, R., R.J. Manders, A.H. Zorenc, G.B. Hul, H. Kuipers, H.A. Keizer, and L.J. van Loon (2005) A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol, 94(1-2):180-7. Koopman, R., A.J. Wagenmakers, R.J. Manders, A.H. Zorenc, J.M. Senden, M. Gorselink, H.A. Keizer, and L.J. van Loon (2005) Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab, 288(4):E645-53. Manders, R.J., A.J. Wagenmakers, R. Koopman, A.H. Zorenc, P.P. Menheere, N.C. Schaper, W.H. Saris, and L.J. van Loon (2005) Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. Am J Clin Nutr, 82(1):76-83. Punyadeera, C., A.H. Zorenc, R. Koopman, A.J. McAinch, E. Smit, R.J. Manders, H.A. Keizer, D. Cameron-Smith, and L.J. van Loon (2005) The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol, 152(3):427-36. van Loon, L.J., R.J. Manders, R. Koopman, B. Kaastra, J.H. Stegen, A.P. Gijsen, W.H. Saris, and H.A. Keizer (2005) Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia, 48(10):2097-107. Kaastra, B., R.J. Manders, E. Van Breda, A. Kies, A.E. Jeukendrup, H.A. Keizer, H. Kuipers, and L.J. van Loon (2006) Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc, 38(2):268-75. Koopman, R., R.J. Manders, R.A. Jonkers, G.B. Hul, H. Kuipers, and L.J. van Loon (2006) Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol, 96(5):525-34. Koopman, R., L. Verdijk, R.J. Manders, A.P. Gijsen, M. Gorselink, E. Pijpers, A.J. Wagenmakers, and L.J. van Loon (2006) Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr, 84(3):623-32. Manders, R.J., R. Koopman, W.E. Sluijsmans, R. van den Berg, K. Verbeek, W.H. Saris, A.J. Wagenmakers, and L.J. van Loon (2006) Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic men. J Nutr, 136(5): 1294-9.